Distribution of human papillomavirus type 16 E6 and E7 gene variants in the progression of cervical dysplasia in Korean women

Lee, Chungwon; Bae, Jeong-Hoon; Lee, Sung-Jong; Ho, Eun-Mi; Lee, Il-Han; Park, Yong Gyu; Park, Jong Sup

doi:10.1111/j.1447-0756.2010.01520.x

Cited by 10 publications

(19 citation statements)

References 28 publications

(67 reference statements)

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“…Although the HPV‐16 European lineage was more prevalent than the non‐European lineage, the proportion of European sublineages differed among these three countries; the prevalence of the HPV‐16 European (Asian) sublineage was higher in Japan and Vietnam than in the Philippines, and no European (Prototype) sublineage was found in Vietnam. The proportion of European (Prototype) and European (Asian) sublineages in Japan (19.4% and 80.6%, respectively) was similar to that in China and Korea while the proportion in the Philippines (75.0% and 20.8%, respectively) was similar to that in Australia and New Caledonia [Lee et al, 2011; Tornesello et al, 2011]. The HPV‐52 lineage B showed a significantly higher prevalence in Japan (92.3%) compared to the Philippines (62.5%) and Vietnam (73.7%).…”

Section: Discussionmentioning

confidence: 85%

“…Most of the HPV‐16 variants with E6 E113D were found in Japan (92.3%) in the current study. This variant has been identified also in other East Asian countries, such as China (8.0–14.5% of all HPV‐16 strains isolated in the reports), Korea (3.5–5.4%), and Hong Kong (3.1%), but very seldom in other areas [Chan et al, 2002; de Boer et al, 2004; Tornesello et al, 2004; Choi et al, 2007; Qiu et al, 2007; Lurchachaiwong et al, 2009; Lee et al, 2011]. The HPV‐16 European (Prototype) variant with E6 L83V, D113D, and E7 L28F was found only in Japan in the current study and has been reported in Thailand [Lurchachaiwong et al, 2009].…”

Section: Discussionmentioning

confidence: 99%

“…The HPV‐16 variant with E7 N29S, one of the essential mutations for the European (Asian) sublineages, was identified in 80.6% of Japanese HPV‐16 strains (n = 31). This variant is prevalent mainly in East Asia in China (70.2%), Korea (53.2–73.0%), and Hong Kong (58.0%), followed by Indonesia (22.7%), Thailand (14.3%), and India (1.7–37.8%) [Chan et al, 2002; Tornesello et al, 2004; Chopjitt et al, 2009; Lurchachaiwong et al, 2009; Vrtačnik Bokal et al, 2010; Lee et al, 2011]. The European (Asian) sublineage with E6 D25E was found only in Vietnam in the current study.…”

Section: Discussionmentioning

confidence: 99%

“…Some specific amino acid mutations in HPV‐16 E6 have been reported to be associated with a greater capacity for carcinogenesis. The European (Asian) sublineage characterized by D25E [Sun et al, 2012], European (Prototype) sublineage with L83V, non‐European lineage with Q14H/H78Y/L83V (corresponding to the African‐1 and ‐2, Asian‐American‐1 and ‐2, and North American 1 sublineages) [Lizano et al, 2009; Zehbe et al, 2009; Richard et al, 2010; Schiffman et al, 2010; Chansaenroj et al, 2012], and HPV‐16 E7 N29S mutations are considered to be related to the development of cervical cancer in Asian populations [Chan et al, 2002; Choi et al, 2007; Lee et al, 2011; Chansaenroj et al, 2012]. However, no significant correlation between abnormal cervical cytology and intragenotypic variations of either HPV‐16 or ‐52 sublineages or between abnormal cervical cytology and the specific amino acid mutations at HPV‐16 E6 D25E, E6 L83V, and E7 N29S was observed in the current study.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, HPV‐16 intragenotypes based on E6 and E7 genes have been investigated and showed different global geographical distribution [Yamada et al, 1995; 1997; Huertas‐Salgado et al, 2011]. Some epidemiological studies have found that the HPV‐16 non‐European lineage is related more strongly to cervical cancer, but others found that the prevalent variants could differ by population [Chang et al, 2011; Huertas‐Salgado et al, 2011; Lee et al, 2011; Tornesello et al, 2011; Zuna et al, 2011]. HPV‐52 intragenotypes are categorized into four lineages, A–D, based on HPV‐52 complete genome analysis [Chen et al, 2011b].…”

Section: Introductionmentioning

confidence: 99%

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E6 and E7 variants of human papillomavirus‐16 and ‐52 in Japan, the Philippines, and Vietnam

Ishizaki

Matsushita

Hoang

et al. 2013

Journal of Medical Virology

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Human papillomavirus (HPV) has several intragenotypic variants with different geographical and ethnic distributions. This study aimed to elucidate the distribution patterns of E6 and E7 (E6/E7) intragenotypic variants of HPV type 16 (HPV-16), which is most common worldwide, and HPV-52, which is common in Asian countries such as Japan, the Philippines, and Vietnam. In previous studies, genomic DNA samples extracted from cervical swabs were collected from female sex workers in these three countries and found to be positive for HPV-16 or HPV-52. Samples were amplified further for their E6/E7 genes using type-specific primers and analyzed genetically. Seventy-nine HPV-16 E6/E7 genes were analyzed successfully and grouped into three lineages: European (Prototype), European (Asian), and African-2. The prevalences of HPV-16 European (Prototype)/European (Asian) lineages were 19.4%/80.6% (n=31) in Japan, 75.0%/20.8% (n=24) in the Philippines, and 0%/95.8% (n=24) in Vietnam. The 109 HPV-52 E6/E7 genes analyzed successfully were grouped into four lineages, A to D; the prevalences of lineages A/B/C/D were respectively 5.1%/ 92.3%/0%/2.6% in Japan (n=39), 34.4%/62.5%/0%/3.1% in the Philippines (n=32), and 15.8%/73.7%/7.9%/2.6% in Vietnam (n=38).The distribution patterns of HPV-16 and HPV -52 lineages in these countries differed significantly (p<0.000001 and p=0.0048, respectively). There was no significant relationship between abnormal cervical cytology and either HPV-16 E6/E7 lineages or specific amino acid mutations, such as E6 D25E, E6 L83V, and E7 N29S. Analysis of HPV-16 and HPV-52 E6/E7 genes can be a useful molecular-epidemiological tool to distinguish geographical diffusion routes of these HPV types in Asia.3

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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E6 and E7 variants of human papillomavirus‐16 and ‐52 in Japan, the Philippines, and Vietnam

Ishizaki

Matsushita

Hoang

et al. 2013

Journal of Medical Virology

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Human Papillomavirus Type 16 Sequence Variation in Concurrent Vulvar and Penile Carcinoma in a Married Couple

Mitamura¹,

Watari²,

Yamashiro³

et al. 2015

Sexually Transmitted Diseases

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Association of human papillomavirus type 16 and its genetic variants with cervical lesion in Korea

Park

Shin

Kim

et al. 2016

APMIS

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Association of human papillomavirus type 16 and its genetic variants with cervical lesion in Korea. APMIS 2016; 124: 950-957. Persistent human papillomavirus type 16 (HPV16) is the major risk factor for cervical cancer. HPV16 intratypic variants differ in their geographical distribution and oncogenic potential. This study aimed to analyze the distribution of HPV16 variants and their association with cervical lesion histopathology in Korean women. In total, 133 HPV16-positive cervical samples from women admitted to Seoul National University Boramae Hospital were analyzed by sequencing E6, E7, and L1 genes and the long control region (LCR), and the variant distribution according to cervical lesion grade was determined. Isolates were grouped into a phylogenetic lineage, and A1-3, A4, C, and D sublineages were detected in 54.1, 37.8, 0.7, and 7.4% of samples, respectively. The most commonly observed LCR variations were 7521G>A (91.5%), 7730A>C (59.6%), and 7842G>A (59.6%). Furthermore, A4 or D sublineage-positive women had a higher risk for cervical cancer than women who were positive for A1-3. Among HPV phylogenetic clusters, A1-3 was the predominant sublineage, and within A1-3, the 350G polymorphism was highly frequent. These results differed from those of previous studies in Korea and other Asian countries. The findings suggest that cervical neoplasia incidence in HPV16-infected patients could be affected by the distribution of HPV16 variants in the population.Key words: Human papillomavirus 16; variant; cervical cancer; cervical intraepithelial neoplasia; case-control study.Sue Shin, Department of Laboratory Medicine, Seoul National University Boramae Hospital, 156-707, 20 Boramaero-5-gil, Dongjak-gu, Seoul, Korea. e-mail: jeannie@snu.ac.krThe incidence rate of cervical cancer in Korea is higher than that in other developed countries. In 2012, the reported incidence was 14.2 cases per 100 000 women, with 3584 new cases and 889 deaths (1). Persistent infection by oncogenic human papillomaviruses (HPV) is strongly associated with the development of cervical neoplasia. Oncogenic HPV type 16 (HPV16) accounts for approximately 65% of cervical cancer worldwide (2) and is the most common HPV type associated with cervical cancer in Korea (3).The HPV oncogenes, E6 and E7, are consistently expressed in cervical cancers, and these genes are involved in HPV-mediated carcinogenesis (4). Currently, HPV16 intratypic variants, which have nucleotide sequence variations of ≤2% as compared with the HPV16 prototype, are classified into four major lineages based on whole-genome sequencing: A, which includes the A1-3 (previously named European), and A4 (Asian) sublineages; B (African 1); C (African 2); and D [including Asian-American (AA) and North American (NA)] (5). The long control region (LCR) adjacent to the downstream region of E6 contains the early promoter and regulatory elements involved in viral DNA replication and transcription (6). Epidemiological studies have reported that HPV16 variants confer different risks of vira...

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Distribution of human papillomavirus type 16 E6 and E7 gene variants in the progression of cervical dysplasia in Korean women

Abstract: The distribution of HPV variants appears to be related to geographic difference. Human papillomavirus 16 E6 Thymine178Guanine and E7 Adenine647Guanine can be used as the candidate marker for the progression of the cervical neoplasia.

Cited by 10 publications

References 28 publications

E6 and E7 variants of human papillomavirus‐16 and ‐52 in Japan, the Philippines, and Vietnam

E6 and E7 variants of human papillomavirus‐16 and ‐52 in Japan, the Philippines, and Vietnam

Human Papillomavirus Type 16 Sequence Variation in Concurrent Vulvar and Penile Carcinoma in a Married Couple

Association of human papillomavirus type 16 and its genetic variants with cervical lesion in Korea

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