Distribution of HLA-B27 in patients with juvenile rheumatoid arthritis.

Mitsui, Hiroyuki; Juji, Takeo; Sonozaki, H; Seki, H; Watanabe, Nobuo

doi:10.1136/ard.36.1.86

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…Above-normal frequencies have been found in JCA patients with both the polyarticular and the pauciarticular-onset subtypes [1,3,[5][6][7][8]10], although in some series this phenomenon seemed to be restricted to late-onset pauciarticular disease [4,12]. Only a few studies have shown elevated frequencies in seropositive adult-type JCA [11] or in Still's disease [8,10], whereas several others have revealed normal [3,4,10,[12][13][14] or only marginally elevated frequencies in these subtypes of JCA or in JCA patients in general [2,[15][16][17][18].…”

Section: Introductionmentioning

confidence: 98%

HLA B27: A prognostic factor in juvenile chronic arthritis

Savolainen¹,

Lehtimäki

Kautiainen³

et al. 1998

Clin Rheumatol

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This study was performed to assess the frequency of HLA B27 in patients with juvenile chronic arthritis (JCA) of varying severity and outcome by studying three patient categories: those in whom cytostatic treatment with azathioprine had been started, those with secondary amyloidosis, and those with arthroplasty of the knee or hip joints. In the first category the frequency of the HLA B27 allele was compared between those who had attained remission and those who had not. In the second and third categories the rate at which amyloidosis developed and the timing for the need of arthroplasty, were compared for HLA B27-positive and -negative patients. A control group consisted of 37 patients with uncomplicated seronegative polyarthritis. Ten of the 37 patients in the control group (27%) were HLA B27 positive as opposed to 84 out of 190 (44%) in the three study groups. Of the 101 patients treated with azathioprine, two out of 15 in remission were HLA B27 positive, whereas as many as 41 out of 86 with still active disease were HLA B27 positive (p = 0.013). Of the secondary amyloidosis patients, 29 out of 51 carried HLA B27. The HLA B27-positive patients contracted amyloidosis on average 5.9 (median 6.7) years earlier than the HLA B27-negative patients (p = 0.038). Of the arthroplasty patients, 39 out of 91 carried HLA B27. The HLA B27-positive patients underwent arthroplasty on average 2.9 (median 3.5) years earlier than the HLA B27-negative patients (p = 0.050). We conclude that HLA B27-positive cases are accumulated among the most severe cases of JCA.

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Section: Introductionmentioning

confidence: 98%

HLA B27: A prognostic factor in juvenile chronic arthritis

Savolainen¹,

Lehtimäki

Kautiainen³

et al. 1998

Clin Rheumatol

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show abstract

“…πάσχοντας έκ ρευμα τοειδούς άρθρίτιδος τής εφηβικής ηλικίας, 242 ένώ εις την Ίαπωνίαν εις ασθενείς μέ την αυτήν νόσον τό ανωτέρω άντιγόνον δέν άνευρέθη ούδαμοΰ. 243 Παρόμοιον φαινόμενον άφορα τό γλαύκωμα 203 καί πλείστος αλλάς ασθενείας, είναι δέν άνάλογον τοΰ ήδη συζητηθέντος φαινομένου τοϋ παρατηρουμένου κατά τάς μεταμοσχεύσεις. γ) Τέλος τό ύποτιθέμενον γονίδιον τό ύπεύθυνον εμμέσως διά τήν νόσον δυνατόν νά είναι συνδεδεμένον μέ άλλοτε άλλου βαθμού δεσμόν μέ διάφορα εκάστοτε αντιγόνα ή νά μή δεικνύη ούδεμίαν σύνδεσιν μέ ούδένα τούτων.…”

Section: αποτελέσματα τρίτης ύποομάδος 1η κατηγορίαunclassified