Distribution of Helicobacter pylori colonisation and associated gastric inflammatory changes: difference between patients with duodenal and gastric ulcers.

Louw, J. A.; Falck, Vincent; Rensburg, Christo van; Žák, J.; Adams, G.; Marks, I. N.

doi:10.1136/jcp.46.8.754

Cited by 54 publications

(31 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The degree of neutrophil in®ltra-tion in the body in duodenal ulcer patients was signi®cantly smaller in comparison with those with chronic gastritis in spite of the fact that there was no difference in the density of H. pylori and mucosal IL-8 content between the two groups. In general, duodenal ulcer patients are known to have high acid secretion, 18,19 and fewer DU patients have been reported to have histological gastritis in the body in comparison with those who do not have ulcer or those who have gastric ulcer. 20,21 This was assumed by Solcia et al 20 to be attributable to the possibility of attenuation of the damage caused by H. pylori on the mucosa through the transformation from ammonia to ammonium chloride by acid.…”

Section: Discussionmentioning

confidence: 99%

Gastric corpus IL‐8 concentration and neutrophil infiltration in duodenal ulcer patients

Uemura

Oomoto

Mukai

et al. 1997

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Background: The purpose of the present study was to examine the association between interleukin‐8 (IL‐8) in the gastric body due to Helicobacter pylori infection and histological gastritis, as well as elucidating the effect of acid secretion inhibitors on H. pylori associated body gastritis in duodenal ulcer patients. Methods: Twenty H. pylori‐negative patients, 20 H. pylori‐positive patients with chronic gastritis without peptic ulceration, and 20 H. pylori‐positive duodenal ulcer patients (DU) were studied. Four biopsy samples were taken, each from the greater curvature of the antrum and body of the stomach. Biopsies were histologically investigated by ELISA to determine the density of H. pylori, the degree of neutrophil infiltration and the IL‐8 concentration in the mucosa. Results: In the gastric mucosa of H. pylori‐negative subjects, no IL‐8 and hardly any neutrophil infiltration were observed. In contrast, enhanced IL‐8 production and increased neutrophil infiltration were present in those infected with H. pylori. In H. pylori‐positive patients, a significant correlation was observed between the IL‐8 concentration and the degree of neutrophil infiltration, but no correlation was found in the body mucosa of those with DU. Twelve of 20 DU patients demonstrated hardly any neutrophil infiltration, despite the increased mucosal IL‐8 content in the body. The administration of omeprazole in DU patients markedly increased mucosal neutrophil infiltration even though it did not cause any significant change in the H. pylori density and IL‐8 concentration in the body. Although the effect of omeprazole was transient, a significant increase in neutrophil infiltration continued in comparison with the status before omeprazole administration in those subsequently undergoing maintenance treatment with H2‐blockers. Conclusion: In H. pylori‐positive chronic gastritis, IL‐8 concentration is enhanced in the mucosa of the body, and is associated with increased neutrophil infiltration. However, in DU patients, despite increases in body IL‐8 concentration, neutrophil infiltration is reduced and the gastritis may be localized in the antrum.

show abstract

Section: Discussionmentioning

confidence: 99%

Gastric corpus IL‐8 concentration and neutrophil infiltration in duodenal ulcer patients

Uemura

Oomoto

Mukai

et al. 1997

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

“…Previous South African studies 10,13,17 had equally incriminated this organism in cases of duodenal and gastric ulcers.…”

Section: Discussionmentioning

confidence: 99%

“…15,16 Although studies have reported the prevalence of the organism in the country, most adopted a sero-prevalence approach, which does not provide more information other than the presence of antibodies, which are poor markers of active infection. In Cape Town, a prevalence of 63% of the pathogen in NUD patients based on histology reports was documented, 13 and a prevalence of 81% in NUD patients based on serology testing. 17 Published data on the prevalence of the organism in dyspeptic patients in the Eastern Cape province, which is predominantly rural with poor sanitation and household hygiene (factors that favour the spread of H. pylori), are lacking.…”

mentioning

confidence: 99%

“…2,10 Involvement of H. pylori in gastric patients in Cameroon 2 revealed a similar pattern to that recorded among Ghanian patients 12 with dyspeptic symptoms and in South African patients with NUD. 13 The prevalence of H. pylori infection differs in relation to ethnic groups, races and economic conditions. 14 H. pylori infection seems to be common in South Africa, as might be expected in developing countries.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Helicobacter pylori prevalence in dyspeptic patients in the Eastern Cape province - race and disease status

et al. 2010

View full text Add to dashboard Cite

“…[11]. These alterations in acid secretion depend on the degree and distribution of gastritis caused by the infection [29,30]. In subjects with an antral predominant gastritis, without atrophy, acid secretion is normal or increased.…”

Section: H Pylori Infection and Gastric Acid Perturbationmentioning

confidence: 99%

Helicobacter pylori Infection, Gastric Physiology and Micronutrient deficiency (Iron and Vitamin C) in Children in Developing Countries

Sarker¹

2014

Trends in Helicobacter Pylori Infection

View full text Add to dashboard Cite

Distribution of Helicobacter pylori colonisation and associated gastric inflammatory changes: difference between patients with duodenal and gastric ulcers.

Abstract: Aims-To determine the gastric distribution of Helicobacter pylon in patients with duodenal and gastric ulcers; and to examine the mucosal inflammatory response.

Cited by 54 publications

References 11 publications

Gastric corpus IL‐8 concentration and neutrophil infiltration in duodenal ulcer patients

Gastric corpus IL‐8 concentration and neutrophil infiltration in duodenal ulcer patients

Helicobacter pylori prevalence in dyspeptic patients in the Eastern Cape province - race and disease status

Helicobacter pylori Infection, Gastric Physiology and Micronutrient deficiency (Iron and Vitamin C) in Children in Developing Countries

Contact Info

Product

Resources

About