Distribution of glycated haemoglobin and its determinants in Indian young adults

Nagarathna, Raghuram; Kaur, Navneet; Anand, Akshay; Sharma, Kanupriya; Dada, Rima; Sridhar, Palukuru; Sharma, Pravin Kumar; Singh, Amit; Patil, Suchitra; Nagendra, Hongasandra Ramarao

doi:10.1016/j.diabres.2019.107982

Cited by 5 publications

(5 citation statements)

References 59 publications

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“…Additionally, we found that hemoglobin was a negative factor, while BMI was a positive factor for HbA 1c in men. Age was a positive factor for HbA 1c , in both men and postmenopausal women, consistent with results of previous studies [ 27 , 28 ].…”

Section: Discussionsupporting

confidence: 92%

The relationship between sex hormones and glycated hemoglobin in a non-diabetic middle-aged and elderly population

Cao

Shen

et al. 2022

BMC Endocr Disord

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Background Sex hormones are strongly linked to the occurrence and development of diabetes, and influence glycated hemoglobin (HbA1c) levels in diabetic population; but, the relationship between sex hormones and HbA1c in non-diabetic population remains unknown. This study aimed to explore the extent of influence of sex hormones on HbA1c levels in non-diabetic population. Methods A total of 1409 non–diabetic subjects, including 601 men and 808 postmenopausal women were recruited from Shanghai community. HbA1c was detected using high performance liquid chromatography, and hemoglobin level was determined by sodium lauryl sulfate colorimetry. Serum estradiol (E2), total testosterone (TT), and sex hormone binding globulin (SHBG) were measured by chemiluminescent microparticle immunoassays. Results The level of HbA1c was 5.6 (5.4–5.9) % in all subjects, with 5.6 (5.4–5.8) % in men and 5.7 (5.5–5.9) % in postmenopausal women. After adjusting for age, body mass index (BMI), and hemoglobin, E2 was positively correlated with HbA1c in men (r = 0.122, P = .003), and SHBG was inversely correlated with HbA1c (r = − 0.125, P < .001) in women. Other hormones were not correlated with HbA1c (all P > .05). Multivariate linear regression analysis showed that, except for traditional factors, such as age, hemoglobin, and BMI, E2 was another determinant of HbA1c (standardized β = 0.137, P = .003) in men; besides, in women, SHBG was another determinant of HbA1c (standardized β = − 0.178, P < .001), except for age and systolic blood pressure. Conclusion After controlling for confounding factors, two sex hormones, as E2 and SHBG could influence HbA1c levels in non-diabetic population.

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Section: Discussionsupporting

confidence: 92%

The relationship between sex hormones and glycated hemoglobin in a non-diabetic middle-aged and elderly population

Cao

Shen

et al. 2022

BMC Endocr Disord

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“…The prevalence of diabetes and prediabetes among younger age groups was higher than reported by Nagarathna et al [27]. This study corroborates another study done by Feng L in China, which concluded that HbA1c and fasting glucose maintained significant correlations within the group with HbA1c < 6.5% and glucose <7.0 mmol/L and the group with HbA1c ≥ 6.5% and glucose ≥7.0 mmol/L in both males and females [14].…”

Section: Hba1csupporting

confidence: 89%

Prevalence Of Diabetes And Association Of Fasting And Postprandial Glucose With Hba1c, 6-Year Study In Reference Laboratory

Gohil,

Singh,

Kambli

et al. 2023

Ann of Pathol and Lab Med

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Background Prevalence of diabetes is estimated in the Indian population using hemoglobin A1c (HbA1c) data collected over the period of 6 years, in the Metropolis Reference Laboratory Mumbai. HbA1c values with gender and age structure was correlated during fasting and postprandial glucose for the non-diabetic, pre-diabetic, and diabetic populations in terms of frequency and percentile. Method Retrospective analysis of HbA1c data obtained in a referral laboratory based in Mumbai over a span of 6 years from 2015 to 2020. A total of 2,94,264 cases were divided in six age groups i.e. 15-20Y, 21-30Y, 31-40, 41-50, 51-60, and >60Y. High-performance liquid chromatographic separation and quantification of HbA1c in blood with gender and age were done. HbA1c values were also correlated with glucose fasting and postprandial in the studied population. Results Prevalence of diabetes (HbA1C >6.5) was 57.60% in the studied population. The incidence and prevalence of HbA1c in the diabetic range were highest in the age group of >60 years. Males showed a higher prevalence of diabetes than females, while females are found to be more pre-diabetic. A significant (p>0.001) positive linear correlation was found between HbA1c with fasting and postprandial glucose, respectively. Conclusion The age group of >60Y showed a maximum diabetic prevalence. Gender disparity was recorded more in males than females having higher HbA1c. The sensitivity of HbA1c is comparable with fasting and postprandial glucose. However, HbA1c cannot replace plasma glucose estimation and could be used in conjunction with fasting and postprandial glucose for proper diagnosis and disease management.

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“…According to American Diabetes Association (ADA), when the person has the HbA1c level between the 5.7-6.4%, FBG-100-125 mg/dl, that person is considered prediabetic (12). HbA1c is considered as most reliable method to know the glycemic status of the person (13). In addition, non-invasive methods like the Indian Diabetes Risk Score founded by Mohan et al (2005) helps to predict the risk status for diabetes based on the two modifiable (age and parental history of diabetes) and two non-modifiable risk factors (waist circumference and level of physical activity) (14).…”

Section: Introductionmentioning

confidence: 99%

Investigating the mitigating role of mind body intervention on glycemic control in prediabetes: A case report

Kaur¹,

Maity²,

Malik³

et al. 2022

IMCR

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In the present case study, the case of a high-risk female participant for diabetes was presented. She is a resident of Dhanas colony, Chandigarh, India. The mapping of risk status for diabetes was done through the Indian Diabetes Risk Score (IDRS) in the participant. She was found to be at high risk for diabetes with a risk score of 60. She joined the Yoga camp organized in the Village Dhanas, Chandigarh. The Diabetic Yoga Protocol (DYP), mainly developed for prediabetics, was given to the participant for 12 weeks. The glycated haemoglbin (HbA1c) was considered the guiding criteria for determining the glycemic threshold for prediabetes. The participant’s HbA1c level was 5.8% at baseline, and fasting blood glucose (FBG) was 93 mg/dl. After the 12 weeks of DYP intervention, a significant decline in the HbA1c (5.3%) and FBG (76.9 mg/dl) levels were seen. The present case report supports the efficacy of DYP as an efficient, secure, and cost-effective in reversing prediabetes into normal by ameliorating the glycemic indices.

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Distribution of glycated haemoglobin and its determinants in Indian young adults

Cited by 5 publications

References 59 publications

The relationship between sex hormones and glycated hemoglobin in a non-diabetic middle-aged and elderly population

The relationship between sex hormones and glycated hemoglobin in a non-diabetic middle-aged and elderly population

Prevalence Of Diabetes And Association Of Fasting And Postprandial Glucose With Hba1c, 6-Year Study In Reference Laboratory

Investigating the mitigating role of mind body intervention on glycemic control in prediabetes: A case report

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