Distribution of glucocorticoid receptor immunoreactivity and mRNA in the rat brain: an immunohistochemical and in situ hybridization study

Morimoto, Masafumi; Morita, Noriyuki; Ozawa, Hitoshi; Yokoyama, Keiko; Kawata, Mitsuhiro

doi:10.1016/s0168-0102(96)01105-4

Cited by 425 publications

(305 citation statements)

References 75 publications

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“…In the rat brain, as we have found in the zebra finch, GR mRNA expression is widespread, with strong labelling in the amygdala, hypothalamus, including the paraventricular nucleus (Aronsson et al 1988;Morimoto et al 1996). The similarity in the distribution of GR mRNA expression between rat and zebra finch implies it is probably that, as in rats, neuronal populations in zebra finches are sensitive to the regulatory action of glucocorticoids.…”

Section: Discussionsupporting

confidence: 61%

Spatial ability is impaired and hippocampal mineralocorticoid receptor mRNA expression reduced in zebra finches ( Taeniopygia guttata ) selected for acute high corticosterone response to stress

et al. 2006

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In mammals, stress hormones have profound influences on spatial learning and memory. Here, we investigated whether glucocorticoids influence cognitive abilities in birds by testing a line of zebra finches selectively bred to respond to an acute stressor with high plasma corticosterone (CORT) levels. Cognitive performance was assessed by spatial and visual one-trial associative memory tasks. Task performance in the high CORT birds was compared with that of the random-bred birds from a control breeding line. The birds selected for high CORT in response to an acute stressor performed less well than the controls in the spatial task, but there were no significant differences between the lines in performance during the visual task. The birds from the two lines did not differ in their plasma CORT levels immediately after the performance of the memory tasks; nevertheless, there were significant differences in peak plasma CORT between the lines. The high CORT birds also had significantly lower mineralocorticoid receptor mRNA expression in the hippocampus than the control birds. There was no measurable difference between the lines in glucocorticoid receptor mRNA density in either the hippocampus or the paraventricular nucleus. Together, these findings provide evidence to suggest that stress hormones have important regulatory roles in avian spatial cognition.

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Section: Discussionsupporting

confidence: 61%

Spatial ability is impaired and hippocampal mineralocorticoid receptor mRNA expression reduced in zebra finches ( Taeniopygia guttata ) selected for acute high corticosterone response to stress

et al. 2006

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“…Taken together with our previous data showing that adrenalectomy or metyrapone treatment abolishes the path integration deficits produced by fenfluramine, the increased levels of CORT and adrenal hypertrophy and thymic involution in this study suggest that CORT may mediate the path integration deficits. Consistent with this, glucocorticoid receptors are present in various brain regions thought to be important for path integration, such as the anterior thalamus and parietal cortex (Morimoto et al, 1996).…”

Section: Effects Of 5-meo-diptmentioning

confidence: 54%

Alterations in Body Temperature, Corticosterone, and Behavior Following the Administration of 5-Methoxy-Diisopropyltryptamine (‘Foxy’) to Adult Rats: a New Drug of Abuse

Williams

Herring

Schaefer

et al. 2006

Neuropsychopharmacol

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Many drugs are used or abused in social contexts without understanding the ramifications of their use. In this study, we examined the effects of a newly popular drug, 5-methoxy-diisopropyltryptamine (5-MEO-DIPT; 'foxy' or 'foxy-methoxy'). Two experiments were performed. In the first, 5-MEO-DIPT (0, 10, or 20 mg/kg) was administered to rats four times on a single day and animals were examined 3 days later. The animals that received 5-MEO-DIPT demonstrated hypothermia during the period of drug administration and delayed mild hyperthermic rebound for at least 48 h. Corticosterone levels in plasma were elevated in a dose-dependent manner compared to saline-treated animals with minor changes in 5-HT turnover and no changes in monoamine levels. In experiment 2, rats were examined in behavioral tasks following either 0 or 20 mg/kg of 5-MEO-DIPT. The animals treated with 5-MEO-DIPT showed hypoactivity and an attenuated response to ( + )-methamphetamine-induced stimulation (1 mg/kg). In a test of path integration (Cincinnati water maze), 5-MEO-DIPT-treated animals displayed deficits in performance compared to the saline-treated animals. No differences were noted in the ability of the animals to perform in the Morris water maze or on tests of novel object or place recognition. The data demonstrate that 5-MEO-DIPT alters the ability of an animal to perform certain cognitive tasks, while leaving others intact and disrupts the endocrine system. 5-MEO-DIPT may have the potential to induce untoward effects in humans.

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“…MRs are almost saturated at basal corticosteroid levels (37), whereas the lower affinity GRs represent a substantial receptor pool that is available for mediating the effects of the increased circulating steroids resulting from stressor exposure (37). In the brain, GRs are broadly expressed in neurons in a range of subregions, including the amygdala (38,39), and are also expressed to a lesser extent in astrocytes (39). GRs are also found in SM (30) and endothelial cells (31).…”

Section: Discussionmentioning

confidence: 99%

Stress-induced glucocorticoid signaling remodels neurovascular coupling through impairment of cerebrovascular inwardly rectifying K ⁺ channel function

Longden¹,

Dabertrand²,

Hill-Eubanks³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Significance When neurons become active, they signal to local arterioles via intermediate glial cells, called astrocytes, to evoke dilation. This increases local blood flow and provides the oxygen and glucose necessary to support ongoing neuronal function. This process is termed neurovascular coupling. We demonstrate that chronic stress—which is a contributing factor for many diseases—impairs neurovascular coupling in the amygdala, a region involved in stressor processing. Our results further indicate that this dysfunction is due to the loss of arteriolar inwardly rectifying potassium (K + ) channel function, which makes vessels less able to respond to vasodilatory K + ions released by astrocytes during periods of increased neuronal activity. This neurovascular coupling impairment may contribute to the pathology of a range of brain disorders.

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Distribution of glucocorticoid receptor immunoreactivity and mRNA in the rat brain: an immunohistochemical and in situ hybridization study

Cited by 425 publications

References 75 publications

Spatial ability is impaired and hippocampal mineralocorticoid receptor mRNA expression reduced in zebra finches ( Taeniopygia guttata ) selected for acute high corticosterone response to stress

Spatial ability is impaired and hippocampal mineralocorticoid receptor mRNA expression reduced in zebra finches ( Taeniopygia guttata ) selected for acute high corticosterone response to stress

Alterations in Body Temperature, Corticosterone, and Behavior Following the Administration of 5-Methoxy-Diisopropyltryptamine (‘Foxy’) to Adult Rats: a New Drug of Abuse

Stress-induced glucocorticoid signaling remodels neurovascular coupling through impairment of cerebrovascular inwardly rectifying K ⁺ channel function

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Distribution of glucocorticoid receptor immunoreactivity and mRNA in the rat brain: an immunohistochemical and in situ hybridization study

Cited by 425 publications

References 75 publications

Spatial ability is impaired and hippocampal mineralocorticoid receptor mRNA expression reduced in zebra finches ( Taeniopygia guttata ) selected for acute high corticosterone response to stress

Spatial ability is impaired and hippocampal mineralocorticoid receptor mRNA expression reduced in zebra finches ( Taeniopygia guttata ) selected for acute high corticosterone response to stress

Alterations in Body Temperature, Corticosterone, and Behavior Following the Administration of 5-Methoxy-Diisopropyltryptamine (‘Foxy’) to Adult Rats: a New Drug of Abuse

Stress-induced glucocorticoid signaling remodels neurovascular coupling through impairment of cerebrovascular inwardly rectifying K + channel function

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Stress-induced glucocorticoid signaling remodels neurovascular coupling through impairment of cerebrovascular inwardly rectifying K ⁺ channel function