Distribution of genes of toxin-antitoxin systems of MazEF and RelBE families in bifidobacteria from human intestinal microbiota

Averina, Olga V.; Алексеева, М. Г.; Абилев, С. К.; Ilyin, Vyacheslav; Даниленко, В. Н.

doi:10.1134/s1022795413030022

Cited by 13 publications

(11 citation statements)

References 22 publications

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“…Previously, genes coding for the members of these toxins were found in the genomes of bifidobacteria [37,3]. To the best of our knowledge, the present study is the first experimental demonstration of the functionality of TAS of bifidobacteria.…”

Section: Introductionmentioning

confidence: 73%

“…Approximately 70% of the RelE, VapC, and MazF toxin superfamily genes have been detected in Proteobacteria, Firmicutes, Cyanobacteria and Actinobacteria phyla [26]. It was shown that the well-characterized type II TAS families MazEF, RelBE, and VapBC [15,36] are widely distributed among human lactobacilli [23] and bifidobacteria [3,49]. Among the strains of bifidobacteria the broadest array of TAS genes was observed in the B. longum subsp.…”

Section: Discussionmentioning

confidence: 98%

“…The other representatives of the B. longum species with full genomic sequences available contain only a few toxin-antitoxin genes in each of the genomes. Usually, these are the genes of the VapC toxin family and genes of the VapB, RelB antitoxin families [3]. The highly conserved orthologous gene relB3 was found in all of the B. longum genomes indicating its possible presence in the common ancestor.…”

Section: Discussionmentioning

confidence: 99%

“…infantis ATCC 15697 genome harbors six bicistronic type II TA gene modules that encode toxin proteins belonging to the RelE, MazF, and VapC toxin superfamilies [3,26] and two solitary genes, including one toxin and one antitoxin genes, with no detectable adjacent partner genes. Among the bicistronic gene modules, two were of the relB-relE type, three were of the relB-mazF type, and one was relB-vapC-like.…”

Section: Identification Of the Ta Systems Of The Mazef And Relbe Famimentioning

confidence: 99%

“…In this work, we sought to determine the biological significance of chromosomally encoded TAS proteins from Bifidobacterium longum subsp. infantis ATCC 15697, a strain which has several type II toxinantitoxin genes [3]. The functional activity of selected TAS genes was tested in E. coli.…”

Section: Introductionmentioning

confidence: 99%

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Functional analysis of the type II toxin–antitoxin systems of the MazEF and RelBE families in Bifidobacterium longum subsp. infantis ATCC 15697

et al. 2015

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Section: Introductionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Identification Of the Ta Systems Of The Mazef And Relbe Famimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Functional analysis of the type II toxin–antitoxin systems of the MazEF and RelBE families in Bifidobacterium longum subsp. infantis ATCC 15697

et al. 2015

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Complete Genome Sequence of Bifidobacterium longum GT15: Identification and Characterization of Unique and Global Regulatory Genes

et al. 2015

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In this study, we report the first completely annotated genome sequence of the Russia origin Bifidobacterium longum subsp. longum strain GT15. Comparative genomic analysis of this genome with other available completely annotated genome sequences of B. longum strains isolated from other countries has revealed a high degree of conservation and synteny across the entire genomes. However, it was discovered that the open reading frames to 35 genes were detected only from the B. longum GT15 genome and absent from other genomes B. longum strains (not of Russian origin). These so-called unique genes (UGs) represent a total length of 39,066 bp, with G + C content ranging from 37 to 65 %. Interestingly, certain genes were detected in other B. longum strains of Russian origin. In our analysis, we examined genes for global regulatory systems: proteins of toxin-antitoxin (TA) systems type II, serine/threonine protein kinases (STPKs) of eukaryotic type, and genes of the WhiB-like family proteins. In addition, we have made in silico analysis of all the most significant probiotic genes and considered genes involved in epigenetic regulation and genes responsible for producing various neuromediators. This genome sequence may elucidate the biology of this probiotic strain as a promising candidate for practical (pharmaceutical) applications.

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Activation of the chromosomally encoded mazEFBif locus of Bifidobacterium longum under acid stress

Wei

Liu

et al. 2015

International Journal of Food Microbiology

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Distribution of genes of toxin-antitoxin systems of MazEF and RelBE families in bifidobacteria from human intestinal microbiota

Cited by 13 publications

References 22 publications

Functional analysis of the type II toxin–antitoxin systems of the MazEF and RelBE families in Bifidobacterium longum subsp. infantis ATCC 15697

Functional analysis of the type II toxin–antitoxin systems of the MazEF and RelBE families in Bifidobacterium longum subsp. infantis ATCC 15697

Complete Genome Sequence of Bifidobacterium longum GT15: Identification and Characterization of Unique and Global Regulatory Genes

Activation of the chromosomally encoded mazEFBif locus of Bifidobacterium longum under acid stress

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