Distribution of GABA-like immunoreactivity in the pigeon brain

Domenici, Luciano; Waldvogel, Henry J.; Matute, Carlos; Streit, P.

doi:10.1016/0306-4522(88)90047-4

Cited by 111 publications

(99 citation statements)

References 61 publications

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“…The paleostriatum primitivum gives rise to most of the GABAergic sub-telencephalic projections of the paleostriatal complex (counterpart of mammalian pallido-tegmental system), via axons of the ansa lenticularis 60 to nucleus dorsointermedius posterior thalami, nucleus spiriformis lateralis and substantia nigra. 84 However, none of those well-documented projection areas showed any statistically significant metabolic changes, suggesting that metabolic stimulation of paleostriatum primitivum might reflect inhibition of the GABAergic cells in paleostriatum primitivum, 44 which in turn does not affect metabolic activity in its projection areas. These findings are in agreement with studies in primates, that suggest that normal tonic activity of pallidal neurons inhibits their target neurons in the thalamus and mesencephalic tegmentum.…”

Section: Basal Ganglia and Motor Related Areasmentioning

confidence: 97%

Performance of appetitive or consummatory components of male sexual behavior is mediated by different brain areas: a 2-deoxyglucose autoradiographic study

Dermon¹,

Stamatakis²,

Tlemçani³

et al. 1999

Neuroscience

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Abstract-The in vivo autoradiographic deoxyglucose method was used to identify the functional brain circuits that are involved in the performance of appetitive and consummatory components of male sexual behavior in Japanese quail (Coturnix japonica). Two groups of castrated, testosterone-treated male quail were trained during 12 sessions to associate the view of a female behind a window with the opportunity to interact freely and to copulate with her. They developed, as a consequence, a social proximity response (staying close and looking through the window providing a view of the female) that has been used in previous experiments to measure appetitive sexual behavior. A third control group (also castrated and treated with testosterone) was allowed to view the female but not to copulate with her and therefore did not develop this proximity response. 2-14 C-deoxyglucose was then injected i.p. to these birds and they were allowed to either copulate freely with a female (consummatory sexual behavior group) or express the social proximity response (appetitive sexual behavior group). The control group was provided a view of the female but these birds, although they were exposed to the same stimuli as birds in the appetitive group, did not express the social proximity response because they had never learned the association with the opportunity to copulate. Birds were killed 45 min after the deoxyglucose injection and their brains were processed for autoradiography. Densitometric analyses of the autoradiograms revealed that the expression of appetitive or consummatory aspects of male sexual behavior was associated with significant increases by comparison with the control group in the deoxyglucose incorporation in the nucleus mesencephalicus lateralis, pars dorsalis and in the nucleus leminsci lateralis. In addition, an increase in the deoxyglucose incorporation was specifically observed in the paleostriatum primitivum, rostral preoptic area, nucleus intercollicularis, nucleus interpeduncularis and third nerve but a decrease was observed in the dorsomedial part of the hippocampus and in the nucleus nervi oculomotori in birds of the consummatory sexual behavior group by comparison with controls. By contrast, in the appetitive sexual behavior group, significant increases in deoxyglucose incorporation were observed in two telencephalic areas, the intermediate hyperstriatum ventrale and neostriatum caudolaterale by comparison with the controls, but decreases were detected in the stratum griseum et fibrosum superficiale of optic tectum by comparison with the consummatory behavior group.These studies demonstrate that the performance of appetitive or consummatory components of male sexual behavior affects in a specific manner the deoxyglucose uptake and accumulation in specific regions of the quail brain. Changes in metabolic activity were observed in steroid-sensitive areas, in auditory, visual and vocal brain regions, and in brain nuclei related to motor behavior but also in association telencephalic and limbic structures. T...

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Section: Basal Ganglia and Motor Related Areasmentioning

confidence: 97%

Performance of appetitive or consummatory components of male sexual behavior is mediated by different brain areas: a 2-deoxyglucose autoradiographic study

Dermon¹,

Stamatakis²,

Tlemçani³

et al. 1999

Neuroscience

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“…23,93 Veenman and Reiner 93 report that the distributions of GAD+ and GABA+ cells overlap almost completely, and they estimate the fraction of GABAergic neurons to be about 10-12% in the neo-and hyperstriatum, showing only slight regional differences. According to the present results, GAD+ neurons do not express DARPP-32 and do not receive input from THbaskets.…”

Section: Co-localization Of Glutamate Decarboxylase With Darpp-32 Andmentioning

confidence: 99%

The dopaminergic innervation of the pigeon telencephalon: distribution of DARPP-32 and co-occurrence with glutamate decarboxylase and tyrosine hydroxylase

et al. 1998

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Abstract--Dopaminergic axons arising from midbrain nuclei innervate the mammalian and avian telencephalon with heterogeneous regional and laminar distributions. In primate, rodent, and avian species, the neuromodulator dopamine is low or almost absent in most primary sensory areas and is most abundant in the striatal parts of the basal ganglia. Furthermore, dopaminergic fibres are present in most limbic and associative structures.Herein, the distribution of DARPP-32, a phosphoprotein related to the dopamine D1-receptor, was investigated in the pigeon telencephalon by immunocytochemical techniques. Furthermore, co-occurrence of DARPP-32-positive perikarya with tyrosine hydroxylase-positive pericellular axonal ''baskets'' or glutamate decarboxylase-positive neurons, as well as co-occurrence of tyrosine hydroxylase and glutamate decarboxylase were examined. Specificity of the anti-DARPP-32 monoclonal antibody in pigeon brain was determined by immunoblotting. The distribution of DARPP-32 shared important features with the distribution of D1-receptors and dopaminergic fibres in the pigeon telencephalon as described previously. In particular, DARPP-32 was highly abundant in the avian basal ganglia, where a high percentage of neurons were labelled in the ''striatal'' parts (paleostriatum augmentatum, lobus parolfactorius), while only neuropil staining was observed in the ''pallidal'' portions (paleostriatum primitivum). In contrast, DARPP-32 was almost absent or present in comparatively lower concentrations in most primary sensory areas. Secondary sensory and tertiary areas of the neostriatum contained numbers of labelled neurons comparable to that of the basal ganglia and intermediate levels of neuropil staining. Approximately up to one-third of DARPP-32-positive neurons received a basket-type innervation from tyrosine hydroxylasepositive fibres in the lateral and caudal neostriatum, but only about half as many did in the medial and frontal neostriatum, and even less so in the hyperstriatum. No case of colocalization of glutamate decarboxylase and DARPP-32 and no co-occurrence of glutamate decarboxylase-positive neurons and tyrosine hydroxylase-basket-like structures could be detected out of more than 2000 glutamate decarboxylase-positive neurons examined, although the high DARPP-32 and high tyrosine hydroxylase staining density hampered this analysis in the basal ganglia.In conclusion, the pigeon dopaminergic system seems to be organized similar to that of mammals. Apparently, in the telencephalon, dopamine has its primary function in higher level sensory, associative and motor processes, since primary areas showed only weak or no anatomical cues of dopaminergic modulation. Dopamine might exert its effects primarily by modulating the physiological properties of non-GABAergic and therefore presumably excitatory units. 1998 IBRO. Published by Elsevier Science Ltd.Key words: DARPP-32, dopamine, D1 receptor, glutamate decarboxylase, tyrosine hydroxylase, pigeon, immunocytochemistry.The mesotelencephalic dopaminergic syst...

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“…The immunohistochemical staining procedure was similar to that applied in an investigation of adult pigeon brains (Domenici et al, 1988). Thus, in all experiments, three washes of 5 min each followed the incubation with antibodies.…”

Section: Tissue Processingmentioning

confidence: 99%

Changing distribution of GABA-like immunoreactivity in pigeon visual areas during the early posthatching period and effects of retinal removal on tectal GABAergic systems

et al. 1989

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The distribution of GABA-like immunoreactivity in the pigeon visual system was studied during the first 9 days after hatching using a mouse monoclonal antibody, mAb 3A12, to glutaraldehyde linked GABA . GABA-like immunoreactivity was seen in cell bodies as well as in neuropil at the level of both the retina and central visual regions at any posthatching age. However, the distribution of putative GABAergic cells and processes varied with age reaching the adult pattern at around 9 days. As a general observation, almost no cell bodies in the retina (except for some perikarya in the ganglion cell layer) were labeled at hatching but densely packed immunostained processes were present in the inner plexiform layer. During the next few days, GABA-immunoreactive amacrine and horizontal cells appeared and the adult distribution of GABA-like immunoreactivity was reached at around 9 days. In the other visual regions examined, the general trend in the variation of GABA-like immunoreactivity included: (1) a progressive decrease in the density of immunostained cell bodies and (2) an almost parallel increase in the concentration of stained neuropil. Since in pigeons the adult organization of visual pathways and the final distribution of putative GABAergic systems are reached at around the same age, we suggest the possibility that incoming ganglion cell axons play a role in regulating the distribution of GABA-like immunoreactivity in visual areas. This hypothesis is supported by the fact that the distribution of GABA-like immunoreactivity in the superficial layers of the optic tectum was altered following ablation of the contralateral retina immediately after hatching.

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Distribution of GABA-like immunoreactivity in the pigeon brain

Cited by 111 publications

References 61 publications

Performance of appetitive or consummatory components of male sexual behavior is mediated by different brain areas: a 2-deoxyglucose autoradiographic study

Performance of appetitive or consummatory components of male sexual behavior is mediated by different brain areas: a 2-deoxyglucose autoradiographic study

The dopaminergic innervation of the pigeon telencephalon: distribution of DARPP-32 and co-occurrence with glutamate decarboxylase and tyrosine hydroxylase

Changing distribution of GABA-like immunoreactivity in pigeon visual areas during the early posthatching period and effects of retinal removal on tectal GABAergic systems

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