Distribution of ferritin, transferrin and lactoferrin in breast carcinoma tissue.

Abstract

SUMMARY An immunoperoxidase staining technique was used for detecting three major iron binding proteins (ferritin, transferrin and lactoferrin) in 40 breast carcinoma cases and six benign breast proliferative lesions.Ferritin staining was detected mainly in connectival stroma and in histiocytes surrounding neoplastic cells. Few and faint ferritin positivities were also detected in neoplastic cells of 20 carcinoma cases. Transferrin was found inconsistently in myoepithelial cells surrounding normal ductules, or around neoplastic ducts of ductal in situ carcinoma. In eight carcinoma cases, transferrin staining was also positive in neoplastic cells. Lactoferrin was detected only in normal breast epithelial cells and in benign breast proliferative lesions.These immunohistochemical findings may suggest that raised serum ferritin concentrations in breast carcinoma patients might be attributed to stromal reaction rather than to tumour synthesis.

Isolation of a lactoferrin cDNA clone and its expression in human breast cancer

“…No obvious clinical correlate was found and more tumours are being examined before meaningful statistical analysis can be performed. The frequency of positivity reported here is in line with the immunocytochemical data of Wurster et al (1980) and Wrba et al (1986) and it is clear that lactoferrin cannot be considered as a marker of benign lesions as suggested by Rossiello et al (1984). Of the five positive cases reported by Charpin et al (1985), two were DCIS.…”

Transferrin, Ferritin And Na/K Levels in Serum And Breast Cyst Fluid

“…Bazı araştırmacılar meme kist sıvısının katyon içeriğinin, kist tipinin belirlenmesine yardımcı olacağını öne sürmüşlerdir (1,6). Eğer kist sıvısı Na+/K+ oranı 2 veya daha az ise kist apokrin epitelden, 3 den daha fazla ise düz epitelden kaynaklanmaktadır (3,5). Düşük Na/K oranı olan kist sıvıla nnın apokrin epitelden kaynaklandığını bildiren çalı~malar bulunmaktadır.…”

“…Elektron mikroskobik çalı~malar ile meme kist epitelindeki apokrin hücrelerin çok sayıda mitakondria ve apikal salgı granülleri ta~ıdığını, düz epitel hücrelerde ise sadece bir kaç organelin bulunduğu gösterilmiştir. Apokrin değişikliklerinin meme kanseri riski yüksek olan kadınlarda daha sıklıkla görüldüğü belirtilmi~tir (3,5,6). Bu çalışmada olguların S'inde Na/K oranı >3 bulunmu~ olup, kistin düz epitel kaynaklı olduğu belirlenmiştir.…”

Iron-binding proteins in adenoid cystic carcinoma of salivary glands: an immunohistochemical study.

“…By immunohistochemistry, the distribution of these iron-binding proteins has been extensively investigated in normal human tissues (Mason and Taylor 1978). In neoplastic conditions, the presence of transferrin, ferritin and lactoferrin has been studied in breast carcinomas (Rossiello et al 1984) and thyroid tumors (Barresi and Tuccari 1987). Lactoferrin has been demonstrated in well differentiated carcinomas of the parotid gland (Caselitz et al 1981a).…”

“…The localization of iron-binding proteins in neoplastic cells appears to be very intriguing, particularly since transferrin is considered an obligate requirement for growing cells (Rossiello et al 1984). In the current study, we aimed to define the immunohistochemical distribution of three iron-binding proteins in different cell types of a large number of ACCs.…”