Distribution of ESBLs, AmpC β-lactamases and carbapenemases among Enterobacteriaceae isolates causing intra-abdominal and urinary tract infections in the Asia-Pacific region during 2008–14: results from the Study for Monitoring Antimicrobial Resistance Trends (SMART)

Jean, Shio-Shin; Hsueh, Po-Ren

doi:10.1093/jac/dkw398

Cited by 90 publications

(65 citation statements)

References 19 publications

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“…Our study revealed a prevalence of the AmpC producing gene of 14.75% among ESBL producing Enterobacteriaceae. In our study, we found out that among all the AmpC producers, the genes producing CIT enzymes were more prevalent mainly in contrary to the study conducted by Jean et al,2017 where most of the E.coli (11.7%) harbored CMY-2 producing enzyme (18).…”

Section: Resultscontrasting

confidence: 89%

Emergence of Multidrug-Resistant Uropathogens harboring ESBL, Carbapenem, Aminoglycosides and AmpC resistant genes from Northern India

Bhattacharjee

Paul

et al. 2018

Preprint

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25Extended-spectrum β-lactamase (ESBL) producing bacteria acts as a serious threat, and its co-existence which included bla NDM-5 (n=48), bla NDM-5 + bla OXA-48 (n=5), bla NDM-5 + bla IMP (n=5) and bla NDM-5 + 37 bla IMP + bla VIM (n=1). The ESBL producing uropathogens also harbored 16S rRNA methylase genes 38 which included rmtB (n=9), rmtA (n=4), rmtC (n=1) and ArmA (n=1) followed by AmpC genes which 39 includes CIT (n=8) and DHA-1 (n=1) genes. Imipenem and gentamicin were found to be more effective. 40We speculating, this is the first report showing the prevalence of multidrug-resistant uropathogens in 41 this area demanding regular surveillance for such resistance mechanisms which will be useful for health 42 personnel to treat ESBL infection and its co-existence with another antibiotic resistance gene.

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Section: Resultscontrasting

confidence: 89%

Emergence of Multidrug-Resistant Uropathogens harboring ESBL, Carbapenem, Aminoglycosides and AmpC resistant genes from Northern India

Bhattacharjee

Paul

et al. 2018

Preprint

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“…Our data reveal that shifting the prevalence of AmpC genes occurred during the short time in our country. In addition, according to Jean et al's [22] study, the most abundant AmpC beta-lactamase variant among clinical isolates of K. pneumoniae in Asia-Pacific region was DHAM.…”

Section: Discussionmentioning

confidence: 99%

First report of coexistence of AmpC beta-lactamase genes in Klebsiella pneumoniae strains isolated from burn patients

Ghanavati

Darban-Sarokhalil

Navab-Moghadam

et al. 2017

AMicr

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Klebsiella spp. are among the most frequently isolated bacteria from burn wounds. These organisms are among the most important opportunistic pathogens, causing hospital-acquired and healthcare-associated infections worldwide. Limited information is available about prevalence of AmpC-producing Klebsiella pneumoniae from burn patients. Therefore, the aim of this study was to determine the characterization of AmpC beta-lactamase among K. pneumoniae isolated from burn patients. Samples were collected from wound specimens of patients with burn injury from a burn hospital in Tehran during 18 months (March 2015 to August 2016). For phenotypic detection of AmpC beta-lactamase, disk diffusion method with cefoxitin was used for screening, AmpC disk test and boronic acid inhibitor-based method were used as confirmatory tests. Polymerase chain reaction (PCR) was performed to screen all isolates with AmpC genes including ACCM, DHAM, EBCM, FOXM, MOXM, and CITM. Finally, PCR products were validated using sequencing. During this study, 102 isolates of K. pneumoniae were collected. Among these isolates, 52.9% suspected as AmpC producer by disk agar diffusion cefoxitin screening method. By confirmatory phenotypic methods, 19.6% of isolates considered as AmpC producer. Molecular analysis revealed 43.1% of cefoxitin-resistant isolates harbored at least one of the AmpC genes including CITM (22.5%), EBCM (21.5%), DHAM (7.8%), and FOXM (0.98%). In addition, 5.8% of isolates harbored two AmpC genes and 2.9% harbored three AmpC genes. In conclusion, K. pneumoniae is becoming a serious problem in burn patients. Accurate and precise methods and guidelines should be designed for detection of antibiotic-resistant mechanisms. Our data showed the high rate of AmpC beta-lactamase among K. pneumoniae isolated from burn patients, which limit the treatment options. Therefore, the results of this study can provide evidence to help for appropriate treatment of burn patients.

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“…Since the incidence of infections due to ESBL + E and AmpC-positive Enterobacteriaceae in Thailand has continuously increased [14] , this study was carried out to gain a better understanding of the intestinal carriage of ESBL + E and identify risk factors for ESBL + E carriage in a community setting in Northern Thailand. Furthermore, this study was extended to include the carriage rate of AmpC-positive Enterobacteriaceae.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors for intestinal carriage of CTX-M-type ESBLs in Enterobacteriaceae from a Thai community

Niumsup

Tansawai

Na-udom

et al. 2017

Eur J Clin Microbiol Infect Dis

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The incidence of infections caused by antimicrobial-resistant Enterobacteriaceae in Thailand is increasing and human intestinal flora is an important reservoir for these organisms. This study was carried out to determine the intestinal carriage of bla extended spectrum ß-lactamase-positive Enterobacteriaceae (ESBL + E) and AmpC-positive Enterobacteriaceae in a community setting in Northern Thailand, and to identify potential risk factors for carriage. A total of 307 fecal samples were collected from healthy volunteers in Phitsanulok province, and cefotaxime-resistant Enterobacteriaceae (CtxRE) were isolated using selective media. Polymerase chain reaction (PCR) was used to detect ESBL and AmpC genes. Risk factors were analyzed using multiple logistic regression. Genotyping was performed by multilocus sequence typing (MLST) analysis. Two hundred ninety-one CtxRE isolates were obtained and Escherichia coli was the predominant organism (66.3%). The intestinal carriage rates of bla ESBL + E and AmpC-positive Enterobacteriaceae were 52.1% and 6.2%, respectively. Comparative levels of bla and bla were found while bla was the predominant genotype among AmpC genes. Co-existence of two ß-lactamase genes in a single isolate was found in 6.5% of isolates. Consumption of undercooked meat was strongly associated with intestinal carriage of bla ESBL + E (p = 0.003, OR = 2.133, 95% CI = 1.289-3.530). Phylogenetic grouping and MLST analysis of E. coli isolates revealed the presence of E. coli B2-ST131 (n = 8). Of these, seven carried bla and 1 carried bla. Our results suggest that residents in Thailand are at high risk for developing endogenous infections caused by antibiotic-resistant Enterobacteriaceae.

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Distribution of ESBLs, AmpC β-lactamases and carbapenemases among Enterobacteriaceae isolates causing intra-abdominal and urinary tract infections in the Asia-Pacific region during 2008–14: results from the Study for Monitoring Antimicrobial Resistance Trends (SMART)

Abstract: The high resistance burden in Vietnam and the Philippines warrants aggressive control policies to combat the worsening trend in antimicrobial resistance among Enterobacteriaceae species causing IAIs.

Cited by 90 publications

References 19 publications

Emergence of Multidrug-Resistant Uropathogens harboring ESBL, Carbapenem, Aminoglycosides and AmpC resistant genes from Northern India

Emergence of Multidrug-Resistant Uropathogens harboring ESBL, Carbapenem, Aminoglycosides and AmpC resistant genes from Northern India

First report of coexistence of AmpC beta-lactamase genes in Klebsiella pneumoniae strains isolated from burn patients

Prevalence and risk factors for intestinal carriage of CTX-M-type ESBLs in Enterobacteriaceae from a Thai community

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