Distribution of endosulfan in cat brain

Khanna, R. N.; Misra, D; Anand, M.; Sharma, Hamayal

doi:10.1007/bf02026911

Cited by 12 publications

(2 citation statements)

References 7 publications

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“…Based on animal studies, a proposed metabolic pathway for endosulfan was published by the Agency for Toxic Substances and Disease Registry (ATSDR, 2000) and is shown in Fig.1. A study using cats reported the immediate presence of endosulfan sulfate in the liver following intravenous administration of endosulfan (Khanna et al, 1979). In rats administered with a single oral dose of 14C-endosulfan, the metabolites sulfate, lactone, ether, and diol were detected in their feces five days later (Dorough et al, 1978).…”

Section: Introductionmentioning

confidence: 99%

Metabolism of Endosulfan-Alpha by Human Liver Microsomes and its Utility as a Simultaneous In Vitro Probe for CYP2B6 and CYP3A4

Casabar¹,

Wallace²,

Hodgson³

et al. 2006

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Section: Introductionmentioning

confidence: 99%

Metabolism of Endosulfan-Alpha by Human Liver Microsomes and its Utility as a Simultaneous In Vitro Probe for CYP2B6 and CYP3A4

Casabar¹,

Wallace²,

Hodgson³

et al. 2006

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“…1. A study using cats reported the immediate presence of endosulfan sulfate in the liver following intravenous administration of endosulfan (Khanna et al, 1979). In rats administered a single oral dose of 14 C-endosulfan, the metabolites sulfate, lactone, ether, and diol were detected in their feces 5 days later (Dorough et al, 1978).…”

mentioning

confidence: 99%

Metabolism of Endosulfan-α by Human Liver Microsomes and Its Utility as a Simultaneous in Vitro Probe for CYP2B6 and CYP3A4

Casabar¹,

Wallace²,

Hodgson³

et al. 2006

Drug Metab Dispos

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Toxicokinetics of ¹⁴C‐endosulfan in male Sprague–Dawley rats following oral administration of single or repeated doses

Chan

Morisawa

Nakayama

et al. 2005

Environmental Toxicology

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Endosulfan (ES), an organochlorine (OC) insecticide that belongs to the cyclodiene group, is one of the most commonly used pesticides to control pests in vegetables, cotton, and fruits. The toxicokinetics of 14C-endosulfan following oral administration of a single dose of 5 mg/kg body weight was investigated in male Sprague-Dawley rats. Three rats were sacrificed 30 min, 1 h, 2 h, 4 h, and 8 h after dosing. 14C-endosulfan radioactivity was detected in all tissues at each time point. In a separate experiment urine and feces were collected for 96 h. The total radioactivity recovered in the excreta for 4 days was 106.8% +/- 26.2%, with fecal elimination the major route of elimination route (94.4% +/- 21.4%). The cumulative excretion in the urine for 4 days was 12.4% +/- 4.8%. Radioactivity 8 h after administration was highest in gastrointestinal (GI) tract tissue (20.28 +/- 16.35 mg ES eq./L) and lowest in muscle (0.18 +/- 0.06 mg ES eq./L). The toxicokinetic parameters obtained from 14C-endosulfan-derived radioactivity in blood were distribution half-life (T1/2 x) = 31 min and terminal elimination half-life (T1/2 y) = 193 h. Blood concentration reached its maximum (Cmax) of 0.36 +/- 0.08 mg ES eq./L 2 h after the oral dose. Endosulfan was rapidly absorbed into the GI tract in rats, with an absorption rate constant (ka) of 3.07 h(-1).

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Distribution of endosulfan in cat brain

Cited by 12 publications

References 7 publications

Metabolism of Endosulfan-Alpha by Human Liver Microsomes and its Utility as a Simultaneous In Vitro Probe for CYP2B6 and CYP3A4

Metabolism of Endosulfan-Alpha by Human Liver Microsomes and its Utility as a Simultaneous In Vitro Probe for CYP2B6 and CYP3A4

Metabolism of Endosulfan-α by Human Liver Microsomes and Its Utility as a Simultaneous in Vitro Probe for CYP2B6 and CYP3A4

Toxicokinetics of ¹⁴C‐endosulfan in male Sprague–Dawley rats following oral administration of single or repeated doses

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Distribution of endosulfan in cat brain

Cited by 12 publications

References 7 publications

Metabolism of Endosulfan-Alpha by Human Liver Microsomes and its Utility as a Simultaneous In Vitro Probe for CYP2B6 and CYP3A4

Metabolism of Endosulfan-Alpha by Human Liver Microsomes and its Utility as a Simultaneous In Vitro Probe for CYP2B6 and CYP3A4

Metabolism of Endosulfan-α by Human Liver Microsomes and Its Utility as a Simultaneous in Vitro Probe for CYP2B6 and CYP3A4

Toxicokinetics of 14C‐endosulfan in male Sprague–Dawley rats following oral administration of single or repeated doses

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Toxicokinetics of ¹⁴C‐endosulfan in male Sprague–Dawley rats following oral administration of single or repeated doses