Distribution of EGFR Mutations in 10,607 Russian Patients with Lung Cancer

Abstract

Biological causes of distinct age- and gender-related distribution of EGFR mutations in LC deserve further investigation.

PCR-based detection of EGFR, ALK, KRAS and BRAF mutations in Russian patients with lung adenocarcinoma: a single-center experience

“…Lung AdCa patient characteristics are presented in Table 1. with lung AdCa were already described in our previous reports [15,16]. The EGFR and ALK mutations in this dataset agree with our previous results of being more prevalent in women and non-smokers (Table 2, Supplementary Table S1).…”

“…The overall frequency of BRAF V600E mutation in Russian lung AdCa patients is estimated to be approximately 1.5% which is at the lower limit of variations reported in patients of European origin (1.6-2.8%) [41][42][43], but it is higher than the frequency observed in Asian patients [27,44]. This difference is likely to be explained by the larger proportion of EGFR-mutant lung AdCa cases in East Asia compared to Europe [45] with intermediate frequency characteristic of the Russian series [16,32].…”

“…In contrast, smoking-related cancers in Russia are usually squamous cell because of previous popularity of high-tar cigarettes. Accordingly, up to half of Russian lung AdCa is seen in never-smokers, and Russian AdCa patients demonstrate approximately twice higher rate of the EGFR mutations and ALK translocations compared to Western countries [15,16]. These findings cause expectation that the distribution of other actionable genetic lesions has characteristic features, and this study therefore analyses the pattern of common somatic mutations in various Russian AdCa patient categories.…”

Drinking Not Drowning: How to Deal With the Deluge of Potential Predictive Biomarker Approaches in Non–Small-Cell Lung Cancer

“…Squamous histology has a lower rate of actionable genetic changes than adenocarcinoma of the lung, but epidermal growth factor mutations and anaplastic lymphoma receptor tyrosine kinase rearrangements, for example, have been described in squamous cases, albeit rarely. 3,4 In reality, histology is a subjective determination by a pathologist. Previous reports have suggested very low k-values for agreement between pathologists on whether an NSCLC exhibits squamous histology.…”

The First Clinical Experience With Afatinib in Russian Federation

“…В аденокарци-номах мутации гена EGFR наиболее часто представлены делецией в 19 экзоне (Del19) и точечными мутациями в 21 экзоне (L858R), которые были диагностированы в 61,2 и 38,8% случаев соответственно [1]. Среди пациентов с НМРЛ определение мутации гена EGFR чаще было ассо-циировано с женским полом, молодым возрастом боль-ного, морфологическим типом опухоли аденокарцино-мой, азиатской популяцией, а также со статусом курения: никогда не курившие пациенты или курившие мало [1].…”