Distribution of dystrophin- and utrophin-associated protein complexes during activation of human neutrophils

Cerecedo, Doris; Cisneros, Bulmaro; Gómez, Pablo; Galván, Iván J.

doi:10.1016/j.exphem.2010.04.010

Cited by 12 publications

(14 citation statements)

References 48 publications

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“…Two alternative DAPC-like complexes were identified by confocal microscope and by immunoprecipitation analyses in both platelets [48] and neutrophils [49], which were composed of Dp71d or Dp71 Δ110 , and β-dystroglycan, α-syntrophin, and α-dystrobrevin-1 and −2. These complexes were found associated with the actin-based cytoskeleton in neutrophils, likely by the interaction of actin with the actinbinding motifs present in Dp71.…”

Section: Formation and Distribution Of The Dp71-containing Dystrophinmentioning

confidence: 99%

Dystrophin Dp71: The Smallest but Multifunctional Product of the Duchenne Muscular Dystrophy Gene

et al. 2011

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Dystrophin Dp71 is expressed in all tissues, with the exception of skeletal muscle, and is the main Duchenne muscular dystrophy (DMD) gene product in brain. As full-length dystrophin does in skeletal muscle, Dp71 associates with dystroglycans, sarcoglycans, dystrobrevins, syntrophins, and accessory proteins to form the dystrophin-associated protein complex (DAPC) in non-muscle tissues. Although it has been nearly 20 years since the discovery of Dp71, its study has become relevant only recently due to its direct involvement with the two main DMD non-muscular phenotypes: cognitive impairment and abnormal retinal physiology. In this review, we describe the historical background of Dp71 and the experimental models developed for its study. Additionally, we present and discuss the experimental evidence supporting the participation of Dp71 in different cellular processes, including cell adhesion, water homeostasis, cell division, and nuclear architecture. The functional diversity of Dp71 is attributed to the formation of Dp71-containing DAPC in numerous cell types and different subcellular compartments, including in plasma membrane and nucleus, as well as to the capability of Dp71-containing DAPC to work as the scaffold for proper clustering and anchoring of structural and signaling proteins to the plasma membrane and of nuclear envelope proteins to the inner nuclear membrane.

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Section: Formation and Distribution Of The Dp71-containing Dystrophinmentioning

confidence: 99%

Dystrophin Dp71: The Smallest but Multifunctional Product of the Duchenne Muscular Dystrophy Gene

et al. 2011

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“…In healthy blood cells, Dg has been described as forming part of actin-based structures such as filopodia and the lamellipodia of platelets [19] and neutrophils [20], contributing to the polarization of the activated forms of these cells. In the HL-60 leukemia cell line, in addition to a structural role, Dg exhibited an important role in modulating the differentiation process of neutrophils, increasing their expression level [21], while in Kasumi-1, another acute leukemia cell line, Dg is dispensable for macrophage differentiation, but is essential for their activities such as phagocytosis and migration, both actin-based functions [22].…”

Section: Introductionmentioning

confidence: 99%

A role for dystroglycan in the pathophysiology of acute leukemic cells

et al. 2017

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“…In hematopoietic stem/progenitor cells, a 50-kDa β-Dg is the main product, while in diferentiated cells, such as neutrophils and platelets, the characteristic glycosylated 43 kDa band is present [29,31]. A 65-kDa band was also observed in neutrophils; perhaps this molecular weight (MW) is due to a postranscriptional modiication such as SUMOylation.…”

Section: Dg and Its Postranscriptional Modiicationsmentioning

confidence: 99%

“…In 1995, utrophin was described as a component of the platelet cytoskeleton, participating in its reorganization [28], while in hematopoietic stem/progenitor cells, Up400 and Up140 comprised the main gene products [29]. In addition, Up71 has been described in platelets [30], as well as in neutrophils [31].…”

Section: Dystrophin-related Proteinsmentioning

confidence: 99%

Dystrophin–Glycoprotein Complex in Blood Cells

Cerecedo¹

2017

Cytoskeleton - Structure, Dynamics, Function and Disease

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The Dystrophin-Associated Protein Complex (DAPC), known as the DystrophinGlycoprotein Complex (DGC), comprises an array of glycoproteins that are essential for the normal function of striated muscle, in which they were irst described, and for many other tissues, including blood. Understanding the role that these molecules play in muscle function has increased over the last decade, and some of the knowledge derived can be applied to other biological systems. However, there is no doubt that to date, some progress has been achieved in blood cells. Multiple interactions have been described among the proteins comprising the DGC, it is now well established that the DGC possesses a crucial role for numerous signaling pathways, recruiting and regulating various signaling proteins into a macromolecular complex. The aim of this chapter is to summarize the current state of knowledge regarding DGC processing and assembly, mainly in muscle tissue and in blood cells, with a primary focus on the dystroglycan heterodimer and associated proteins, including ion channels and membrane lipids. In addition, and due to increasing evidence involving dystroglycan proteins in the pathophysiology of solid tissue cancer, Duchenne muscular dystrophy, and leukemia, current information on these topics will be included.

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Distribution of dystrophin- and utrophin-associated protein complexes during activation of human neutrophils

Cited by 12 publications

References 48 publications

Dystrophin Dp71: The Smallest but Multifunctional Product of the Duchenne Muscular Dystrophy Gene

Dystrophin Dp71: The Smallest but Multifunctional Product of the Duchenne Muscular Dystrophy Gene

A role for dystroglycan in the pathophysiology of acute leukemic cells

Dystrophin–Glycoprotein Complex in Blood Cells

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