Distribution of DNA fragment sizes after irradiation with ions

Abstract

Ionizing radiation is responsible for production of double-strand breaks (DSBs) in a DNA structure. In contrast to sparsely ionizing radiation, densely ionizing radiation produces DSBs that are non-randomly distributed along the DNA molecule and can form clusters of various size. The paper discusses minimalistic models that describe observable patterns of fragment length in DNA segments irradiated with heavy ions and applies the formalism to interpret the recent experimental data collected by use of atomic force microscope (AFM).

DNA studies using atomic force microscopy: capabilities for measurement of short DNA fragments

“…Other investigators have subsequently applied AFM for further studies of radiation induced DNA damage (Murakami et al, 2000 ; Brons et al, 2004 ; Psonka et al, 2005 ; Brezeanu et al, 2007 ; Elsässer et al, 2008 ; Ke et al, 2008 ; Gudowska-Nowak et al, 2009 ; Lee et al, 2009 ; González et al, 2012 ). Of particular relevance to measurement of short DNA fragments by high-LET radiations, Psonka-Antonczyk et al ( 2009 ) investigated DNA breakage by Ni ions and observed a reduced average DNA fragment length after 340-Gy irradiation when compared to X-ray irradiations.…”

Scale-Free Fluctuations in Behavioral Performance: Delineating Changes in Spontaneous Behavior of Humans with Induced Sleep Deficiency

“…: either from the randomization of an individual rate , or correspondingly, from the randomization of relaxation time , the parameters which describe dynamics of stochastic activation events. The interpolation property of the Mittag-Leffler function (stretched-exponential character for short times with a transition to long-time inverse power-law behavior) is an appealing feature, and has been observed experimentally in various realms like protein conformation dynamics [36], dielectric relaxation in complex media [26], [30], [37] or financial market time series [38]. It well may be that the same function can serve in modeling temporal turnover effects in neurological recordings.…”

Magnetization dynamics in Landau–Lifshitz–Gilbert formulation. FMR experiment modeling

“…The complex AC susceptibility Eq. components (19) have been calculated by performing the Fourier transform on the time averaged x-component of magnetiza-…”

“…This type of a compound Poisson-Poisson process has been described in literature by the distribution function known as Neyman distribution (e.g. [18] or more recent [21,19]) which has a strongly multimodal nature contrary to the unimodal Poisson distribution function. An example of such multimodal distribution is shown as the shaded distribution in Fig.…”

“…The specific relation between resonance peaks and correlations introduced by blocked directions of magnetic particles as well as the number of nanoparticles in the [18][19][20].…”