Distribution of cytomegalovirus genotypes among ulcerative colitis patients in Okinawa, Japan

Nahar, Saifun; Hokama, Akira; Iraha, Atsushi; Ohira, Tetsuya; Kinjo, Tetsu; Hirata, Tetsuya; Kinjo, Takeshi; Parrott, Gretchen; Fujita, Jiro

doi:10.5217/ir.2018.16.1.90

Cited by 6 publications

(4 citation statements)

References 44 publications

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“…As the patient can be infected by several genotypes, some of them could be associated to the severity of the disease. Only a few studies have depicted such relation [ 93 , 94 ]; more data are needed, especially around the world as some genotypes are found mainly in Asian countries.…”

Section: Controversial Role Of CMV Infection In Ibd Inflammatory Fmentioning

confidence: 99%

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Cytomegalovirus and Inflammatory Bowel Diseases (IBD) with a Special Focus on the Link with Ulcerative Colitis (UC)

et al. 2020

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Cytomegalovirus (CMV) infects approximately 40% of adults in France and persists lifelong as a latent agent in different organs, including gut. A close relationship is observed between inflammation that favors viral expression and viral replication that exacerbates inflammation. In this context, CMV colitis may impact the prognosis of patients suffering from inflammatory bowel diseases (IBDs), and notably those with ulcerative colitis (UC). In UC, the mucosal inflammation and T helper cell (TH) 2 cytokines, together with immunomodulatory drugs used for controlling flare-ups, favor viral reactivation within the gut, which, in turn, increases mucosal inflammation, impairs corticoid and immunosuppressor efficacy (the probability of steroid resistance is multiplied by more than 20 in the case of CMV colitis), and enhances the risk for colectomy. This review emphasizes the virological tools that are recommended for exploring CMV colitis during inflammatory bowel diseases (IBD) and underlines the interest of using ganciclovir for treating flare-ups associated to CMV colitis in UC patients.

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Section: Controversial Role Of CMV Infection In Ibd Inflammatory Fmentioning

confidence: 99%

“…Detection of CMV DNA in stool specimens could also be an alternative to biopsy examination [ 94 , 100 , 101 , 102 , 103 ]; but, to date, the sensitivity of the assays is too low, leading to false-negative results, even in allograft patients with high viral load in the tissue [ 104 ].…”

Section: Controversial Role Of CMV Infection In Ibd Inflammatory Fmentioning

confidence: 99%

Cytomegalovirus and Inflammatory Bowel Diseases (IBD) with a Special Focus on the Link with Ulcerative Colitis (UC)

et al. 2020

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“…Genotyping of CMV has mainly focused on gB, gN, and gH, which play a role in virus entry and may influence the infectivity or pathogenicity of CMV. 1 , 2 It has been hypothesized that genetic variation among CMV strains may underlie strain-specific clinical manifestations. Our previous research revealed that there might be a potential association between the genotypes of CMV and neonatal thrombocytopenia, and the detection of some specific genotypes might be indicative of severe manifestations in infants with CMV infection.…”

Section: To the Editormentioning

confidence: 99%

Cytomegalovirus genotype distribution among postnatally infected infants: association of glycoprotein B, glycoprotein N and glycoprotein H types with CMV-associated thrombocytopenia

Cheng

Peng³

et al. 2020

Mediterr J Hematol Infect Dis

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The aim of the present study was to identify the virulence of glycoprotein B (gB), glycoprotein N (gN), and glycoprotein H (gH) genotypes of cytomegalovirus(CMV) and assess possible relationships between genotypes and CMV-associated thrombocytopenia. CMV gB, gN, and gH strains were determined by nested PCR and restriction length polymorphism from 30 CMV-associated thrombocytopenia infants infected postnatally and 40 non-thrombocytopenic infants. The gN2 (p = 0.043) and gH2 (p = 0.038) genotypes were associated with an elevated risk of developing thrombocytopenia. gB1 genotype was detected in 80.0% (16/20) of infants with moderately to severely symptomatic CMV disease and was associated with severe manifestations in CMV-associated thrombocytopenia infants (p = 0.022). Conversely, the gN1 genotype was detected in 5.0% (1/20) of infants with moderately to severely symptomatic CMV disease and represent less pathogenic CMV strains (p = 0.044). There may be potential associations between the gN2 and gH2 genotypes of CMV and infantile thrombocytopenia, and that the detection of the gB1and gN1 genotypes may help define the severity of CMV disease in infants.

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“…1 Several envelope glycoproteins, encoded by UL55, UL73, and UL75, including glycoprotein B (gB), glycoprotein N (gN), and glycoprotein H (gH), respectively, have been evaluated in clinical CMV iso-lates because of their influence on tissue tropism and virulence. [2][3][4] The UL144 polymorphisms are concentrated in the 5′ end of the gene, especially in cysteine-rich domain 1 (CRD1), that may bind the B-and T-lymphocyte attenuator proteins. This domain's activity may vary among polymorphisms, leading to a range of clinical symptoms and prognoses.…”

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus Genotype and Virulence in Infants with Congenital Infection

Hu¹,

Jian-gang²,

Sun³

et al. 2021

Journal of Pediatric Infectious Diseases

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Objective Cytomegalovirus (CMV) virulence may depend on genetic variability in several regions of the genome. This study aimed to assess specific CMV genotypes' association with the severity of symptomatic congenital CMV disease at birth. Methods CMV glycoprotein B (gB), glycoprotein N (gN), glycoprotein H (gH), and UL144 strains were identified by nested polymerase chain reaction, restriction fragment length polymorphism, and heteroduplex mobility assay single-stranded conformation polymorphism in 50 infants infected congenitally and 25 asymptomatic infants. Results gN1 (p = 0.010) and UL144-B (p = 0.034) genotypes were associated, by logistic regression, with reduced risk of developing symptomatic congenital CMV infection. gN1 (p = 0.020) and gN3 (p = 0.022) genotypes were associated with reduced risk of severe symptomatic disease. Conversely, gB1 (p = 0.018) was the most virulent genotype and was associated with severe symptoms. Conclusion An association among gB1, gN1, gN3, and UL144-B genotypes of CMV and severity of congenital CMV disease might exist. gB, gN, and UL144 genotypes could be important virological markers of infant infection.

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Distribution of cytomegalovirus genotypes among ulcerative colitis patients in Okinawa, Japan

Cited by 6 publications

References 44 publications

Cytomegalovirus and Inflammatory Bowel Diseases (IBD) with a Special Focus on the Link with Ulcerative Colitis (UC)

Cytomegalovirus and Inflammatory Bowel Diseases (IBD) with a Special Focus on the Link with Ulcerative Colitis (UC)

Cytomegalovirus genotype distribution among postnatally infected infants: association of glycoprotein B, glycoprotein N and glycoprotein H types with CMV-associated thrombocytopenia

Cytomegalovirus Genotype and Virulence in Infants with Congenital Infection

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