Distribution of CYP2C9 and VKORC1 Gene Polymorphisms in Healthy Macedonian Male Population

Jakjovski, Krume; Labachevski, Nikola; Petlichkovski, Aleksandar; Senev, Aleksandar; Trojacanec, Jasmina; Atanasovska, Emilija; Kostova, Elena; Спироски, Мирко

doi:10.3889/mjms.1857-5773.2013.0319

Cited by 3 publications

(6 citation statements)

References 40 publications

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“…The prevalence of CYP2C9*1/*1 in the Sistani ethnic group was higher than Southern Iranian (41.21%) [19] and lower than Iranian Turkmen (76.36%), Mongolian in China (93%), Japanese (94.70%), Macedonian (79.80%) and Mestizo Mexican (83%) [21,22,29].The prevalence of CYP2C9*1/*2 genotype was lower [19] and higher [21,22,29] in comparison with other ethnic groups. Our results show that CYP2C9*1/*3 genotype was higher [22,27,29] than other populations. The prevalence of CYP2C9*2/*2 [21,22,28,29] and CYP2C9*2/*3 [21,22,26,27,29] genotypes were higher than different other populations.…”

Section: Discussionmentioning

confidence: 40%

“…Our results show that CYP2C9*1/*3 genotype was higher [22,27,29] than other populations. The prevalence of CYP2C9*2/*2 [21,22,28,29] and CYP2C9*2/*3 [21,22,26,27,29] genotypes were higher than different other populations.…”

Section: Discussionmentioning

confidence: 40%

“…The most frequently observed mutant allele was CYP2C9*1/*2 allele (22.10%). Our results showed that CYP2C9*1/*3 genotype (11.4%) was higher in the Sistani ethnic group compared to the Japanese (5.3%) [22], Macedonians (0%) [27] and Mestizo Mexicans (6.8%) [29] ( Table 3).…”

Section: Resultsmentioning

confidence: 61%

“…Table 3 shows significant differences in the frequencies of CYP2C9*2 and CYP2C9*3 allelic variants between different populations. The prevalence of CYP2C9*2 in Southern Iranian [25] was higher compared with the Sistanis, but the prevalence of CYP2C9*2 in the Sistani ethnic group was higher than other ethnic groups [21,22,25,[27][28][29]. The prevalence of CYP2C9*3 polymorphism in Sistanis (7.8%) was higher than other populations [21,22,29].…”

Section: Discussionmentioning

confidence: 77%

“…The results also showed that The genotype frequency of CYP2C9*1/*1, CYP2C9*1/*2 CYP2C9*1/ *3, CYP2C9*2/*2, CYP2C9*2/*3 and CYP2C9*3/*3 were 59.30% (95% CI 51-67.60), 22.10% (95% CI 115.10-29.10), 11.40% (95% CI 6.0-16.80), 2.90% (95% CI 0.10-5.70), 4.30% (95% CI 0.9-7.70) and 0% (95% CI 0), respectively ( Table 1). Table 3 is shown that the prevalence of CYP2C9*1/*1 among Sistanee (59.30%) ethnic group was higher when compared with Southern Iran (41.21%) [19], but it lower in comparison with IranianTurkman (76.36%) [18], Mongolian in China (93%) [21], Japanese (94.70%) [22], Macedonians (79.80%) [27], and Mestizo Mexicicans (83%) [29]. The most frequently observed mutant allele was CYP2C9*1/*2 allele (22.10%).…”

Section: Resultsmentioning

confidence: 97%

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Genetic Polymorphism of CYP2C9 Among Sistani Ethnic Group in Gorgan

Marjani

Gharanjik

2017

Ind J Clin Biochem

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Cytochrome P450 2C9 (CYP2C9) is involved in metabolism of many important drugs and its genotype variations is thought to affect drug efficacy and the treatment process. The aim of this study was to assess the distribution of CYP2C9 allele and genotypic variants in Sistani ethnic group, living in Gorgan, South East of Caspian Sea and North East of Iran. This study included 140 Sistani, referred to the health center of Gorgan. CYP2C9 genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism technique. The allele frequency of CYP2C9*1, CYP2C9*2 and CYP2C9*3 was 76.1, 16.1 and 7.8%, respectively. The frequency of CYP2C9*1/*1, CYP2C9*1/*2, CYP2C9*1/*3, CYP2C9*2/*2, CYP2C9*2/*3 and CYP2C9*3/*3 genotypes was 53.9, 22.1, 11.4, 2.9, 4.3% and nil, respectively. In this study the genotypic variations of the CYP2C9 allele among the Sistani ethnic group was investigated and great differences were observed in comparison to other populations. Our findings suggest that different genotypes of may influence the pharmacokinetics of some drugs. More studies on the pharmacokinetic effects of genotypes may help physicians choose optimal dosage of some drugs for treatment and prevention of their side effects. Since different ethnic groups from all over the world use medications, it suggests to investigate the pharmacokinetic effects of genotypes in different populations.

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Section: Discussionmentioning

confidence: 40%

Section: Discussionmentioning

confidence: 40%

Section: Resultsmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 77%

Section: Resultsmentioning

confidence: 97%

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Genetic Polymorphism of CYP2C9 Among Sistani Ethnic Group in Gorgan

Marjani

Gharanjik

2017

Ind J Clin Biochem

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The Frequencies of Allele Distribution of CYP2C9 and CYP2C19 Gene Polymorphisms in Healthy Papuan Population, Indonesia

Tuba

Ikawati

Mustofa

2021

CMUJNS

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This study's objective was to determine the distribution of allele frequencies of CYP2C9 and CYP2C19 gene polymorphisms among the Papuan population, known as the second-largest ethnic group in Indonesia. According to recent research, there is a decrease in CYP2C9 and CYP2C19 produced by humans globally, including in Indonesia. These gene polymorphisms aid in the transmission of various endogenous and exogenous drugs in the human body. Material and Methods: A sum of 99 subjects, comprising 73 male and 26 female subjects aged 20-30 years, were used for this research. PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) analysis using AvaII, NsiI, and SfaNI enzymes tested for the genotypes CYP2C9 and CYP2C19 administered. The distribution of genotypes was calculated in the population (P<0.05) using the Hardy-Weinberg equilibrium. The Faculty of Medicine Gadjah Mada University's Medical and Health Research Ethics Committee (MHREC) accepted this research with written consent. The results revealed that in Papua subjects, CYP2C9*2 (rs1799853) and CYP2C19*17 (rs12248560) alleles were absent while in 17 percent of the population CYP2C9*3 (rs1057910) allele frequency was. In conclusion, CYP2C9*3 has the highest polymorphism rate in Indonesia, with the absence of CYP2C9*2 and CYP2C19*17. Therefore, genetic drift can occur within this ethnic group. Keywords: Genotyping; Papuan ethnic; Pharmacogenetics; Polymorphisms

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Улогата На Медицинската Сестра Во Mакедонската Банка За Хумана ДНК

Cvetkovska¹,

Цветковска²,

Спироски³

2015

Maced Med Electron J

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ОСНОВА: Банка за хумана ДНК (хДНАМКД) претставува складирање на примерок на ДНК од поединецот, како и нејзино безбедно и долгорочно чување со цел да се обезбеди примерок на генетски материјал за медицински и научни истражувања. Македонската банка за хумана ДНК датира од 2000 година и во неа се дефинирани неколку проектни полиња. Медицинската сестра како дел од стручниот тим извршува многу активности со кои учествува во истражувачката дејност на хДНАМКД.ЦЕЛ: Целта е да се презентира улогата на мединцинската сестра во хДНАМКД во сите сегменти во кои таа зема учество почнувајќи од земањето на писмена согласност, земање на примероци, ДНК екстракција и складирање на истата.МАТЕРИЈАЛ И МЕТОДИ: Примероците на ДНК се земени од доброволни дарители по претходно потпишана согласност, доброволно и без притисок. Поединците се информирани во однос на видот на истражувањата што ќе се вршат, аранжманите за пристап и споделување на складираните примероци и времетраењето на чување на примероците. ДНК е изолирана од периферна крв со фенол-хлороформ метод за екстракција. Квалитетот и квантитетот на изолираната геномска ДНК е определен со 260/280 УВ спектрофотометар со GENEQUANT pro RNA/DNA калкулатор. Интактноста на изолираната ДНК е одредена со електорфореза на ДНК на агарозен гел по што истата се аликвотира во нормализирана концентрација и се складира во замрзнувач Heraus Sepatech на -80оЦ.РЕЗУЛТАТИ: Во хДНАМКД се дефинирани три проектни области: антропологија, несродни пациенти и сродни пациенти. Лабораторискиот код за ДНК примероците што се чуваат во Македонската банка за хумана ДНК е MKDSPI. Вкупниот број на примероци кои се складирани во Македонската банка за хумана ДНК до крајот на 2010 година е 5252 примероци – 1575 во антропологијата, 2186 несродни пациенти и 1491 сродни пациенти.ЗАКЛУЧОК: Медицинската сестра има целокупно учество во собирање на сите важни информации за генетските истражувања како земање на семејна историја, медицински информации и доброволна согласност од страна на дарителите. При тоа мора да ги применува етичките приципи за одржување на приватноста и доверливоста на генетски информации. Преку правилно земање и соодветно одбележување на примероците крв таа обезбедува точност на резултатите добиени од генетските истражувања. Претставува неопходен дел од тимот на хДНАМКД заради што треба да има големо искуство и знаење од областа на генетиката и медицинската етика.BACKGROUND: Human DNA Bank (hDNAMKD) provides deposition of a DNA sample of an individual, and its safe and long term storage in order to provide genetic material for medical and scientific research. The Macedonian Human DNA Bank dates back to year 2000 and it covers several project areas. The nurse as a part of the professional team performs many professional activities, by which, she participates in the research activity of hDNAMKD. AIM: Our aim is to present the role of the nurse in hDNAMKD, starting from obtaining informed consent, taking samples, extraction and finally, storage of DNA. MATERIAL AND METHODS: DNA samples are taken from voluntary...

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Distribution of CYP2C9 and VKORC1 Gene Polymorphisms in Healthy Macedonian Male Population

Abstract: Background: Distribution of CYP2C9 and VKORC1 gene polymorphisms may vary significantly among different ethnic groups, and eventually influence the variation in drug metabolism or even failure.

Cited by 3 publications

References 40 publications

Genetic Polymorphism of CYP2C9 Among Sistani Ethnic Group in Gorgan

Genetic Polymorphism of CYP2C9 Among Sistani Ethnic Group in Gorgan

The Frequencies of Allele Distribution of CYP2C9 and CYP2C19 Gene Polymorphisms in Healthy Papuan Population, Indonesia

Улогата На Медицинската Сестра Во Mакедонската Банка За Хумана ДНК

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