Distribution of CYP1A1⁎2A polymorphism in adult patients with acute lymphoblastic leukemia in a Mexican population

Gallegos‐Arreola, Martha Patricia; González-García, Juan Ramón; Figuera, Luis E.; Puebla-Pérez, Ana Marı́a; Delgado-Lamas, José Luis; Zúñiga‐González, Guillermo Moisés

doi:10.1016/j.bcmd.2007.12.001

Cited by 17 publications

(10 citation statements)

References 14 publications

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“…Our results show that CYP1A1*2A is not associated with the susceptibility to develop ALL. This is in agreement with bolufer et al .,[13] and Pakakasama et al .,[19] whereas Krajinovic et al .,[2] Joseph et al .,[18] Gallegos et al .,[15] have reported significant association of this polymorphism to the risk to develop ALL. Balta et al .,[12] in their study in a Turkish population, have reported that homozygous CYP1A1*2A genotype was insignificantly lower in ALL patients compared to controls.…”

Section: Discussionsupporting

confidence: 91%

Role of glutathione-s-transferase and CYP1A1FNx012A polymorphisms in the therapy outcome of south Indian acute lymphoblastic leukemia patients

Nancy

Rajalekshmy

et al. 2011

Indian J Med Paediatr Oncol.

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Background:Polymorphisms in the drug-metabolizing enzymes are found to be associated with the inter-individual variation in response to a particular drug. Glutathione S-transferases (GSTs) are involved in the metabolism of several anticancer drugs, including alkylating agents, anthracyclines, and cyclophosphamides.Aim:The present study is aimed to examine the association of GST and CYP1A1*2A polymorphisms in the susceptibility to acute lymphoblastic leukemia (ALL) and the prognostic significance.Materials and Methods:A total of 92 immunophenotyped patients and 150 cord blood controls were genotyped by PCR for GSTM1 and GSTT1, RQ-PCR allelic discrimination assay for GSTP1 and PCR-RFLP for CYP1A1*2A polymorphism.Results:We have previously reported the significant association of GSTM1 (null) and combined GSTP1 {(Ile/Val)/ (Val/Val)} /GSTM1 (null) genotype with the susceptibility to ALL. No significant association was observed with GSTT1 (P=0.75) and CYP1A1*2A (P=0.61 for +/- and P=0.86 for -/- respectively) in the susceptibility to ALL. Survival analysis was performed in 50 of the 92 patients who were followed for three years. Kaplan-Meier survival analysis for three years showed significant lower event-free survival in patients harboring GSTP1 (Ile/Val) and GSTP1 (Val/Val) (P=0.038 and 0.0001, respectively) genotype. Cox regression analysis revealed GSTP1 as an independent prognostic marker with 6-fold higher risk with Val/Val genotype (P=0.003).Conclusions:Our results show that GSTP1 (Ile/Val) polymorphism has a role in the susceptibility to ALL and also influence treatment outcome.

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Section: Discussionsupporting

confidence: 91%

Role of glutathione-s-transferase and CYP1A1FNx012A polymorphisms in the therapy outcome of south Indian acute lymphoblastic leukemia patients

Nancy

Rajalekshmy

et al. 2011

Indian J Med Paediatr Oncol.

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“…It is also not known if our findings would generalize to the Hispanic population from other geographical regions in the United States, in particular because the Hispanic population in the United States is genetically heterogeneous. A recent study by Gallegos-Arreola and colleagues (2008) in a Mexican population of adult ALL cases and controls showed a frequency of the at risk alleles of CYP1A1*2A of 8% in the controls and 42% in the cases (20), whereas the frequency in our Hispanic controls and cases were 11% and 25%, respectively. Furthermore, Fragoso and colleagues (2005) showed distinct differences among Mexican subpopulations of the CYP1A1 variants (23).…”

Section: Discussioncontrasting

confidence: 51%

“…To our knowledge this is the first investigation that links CYP1A1 polymorphisms to the increased susceptibility of ALL in Hispanic children. Two other studies have found increased risk of cancer susceptibility and CYP1A1 polymorphisms in the Hispanic population, however, both studies report on adult patients with ALL (19,20). The prevalence of the CYP1A1*2A and *2C polymorphisms has been shown to vary among different ethnic groups (21,22).…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in CYP1A1 and Ethnic-Specific Susceptibility to Acute Lymphoblastic Leukemia in Children

Swinney

Beuten

Collier

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. The U.S. Surveillance Epidemiology and End Results (SEER) registry reports that Hispanic children have the highest incidence of ALL, however, it is unclear if this is due to genetic factors, unique environmental exposures, or both. Previous reports have shown an association between CYP1A1 variants and ALL.Methods: To explore the contribution of CYP1A1 polymorphisms to ALL susceptibility in different ethnic groups, we conducted a case-control analysis in Caucasian, Hispanic, and African-American children.Results: Increased risk of developing ALL was found in the whole sample group for homozygosity of variant alleles at CYP1A1*2C (OR 2.51, 95% CI 1.18-5.33, P ¼ 0.016) and CYP1A1*2B (OR 3.24, 95% CI 1.43-7.34, P ¼ 0.005). Stratified analyses showed increased risks in the Hispanic group (CYP1A1*2A, OR 2.70, 95% CI 1.27-5.74, P ¼ 0.010; CYP1A1*2C, OR 2.47, 95% CI 1.13-5.38, P ¼ 0.023; and CYP1A1*2B, OR 3.28, 95% CI 1.40-7.69, P ¼ 0.006) but not for the other ethnic groups. Hispanic control subjects were significantly more likely to be carriers of variant alleles as compared to Caucasians (P < 0.0001) and African Americans (P ¼ 0.005).Conclusions: Our study suggests that polymorphisms in CYP1A1 may contribute to the increased risk of ALL in Hispanic children due to both their impact on leukemia susceptibility and the increased prevalence of the at-risk alleles in the Hispanic population.Impact: Our study provides a novel and specific link between CYP1A1 polymorphisms and ethnic influence on ALL risk that may help explain varying susceptibilities across groups to environmental toxins. Cancer Epidemiol Biomarkers Prev; 20(7); 1537-42. Ó2011 AACR.

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“…The genotypes of CYP1A1 gene MspI, Ile462Val and CYP1B1 gene Arg48Gly, Ala119Ser, Leu432Val, Asp449Asp were determined by using a polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP), the PCR primers were designed based on the Gen-Bank reference sequence and described previously [18,19] (see Table 1 for primer sequences and reaction conditions). The 25 μl reaction mix for each PCR product comprised: 25-50 ng of genomic DNA, 25 mM MgCl 2 , 10× PCR Buffer 3.3 μl, 0.4 pM of each primer, 2.5 mM of each dNTP 3.3 μl, 1 U Taq polymerase (Tiangen) and add DDH 2 O to 25 μl reactions.…”

Section: Dna Extraction and Genotypingmentioning

confidence: 99%

CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women

Cheng

Luo

et al. 2008

J Assist Reprod Genet

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Purpose The aim of the study was to evaluate the association of CYP1A1 and CYP1B1 polymorphisms with uterine leiomyoma in Chinese women. Methods We investigated 100 women with clinically diagnosed uterine leiomyoma and 110 healthy normal subjects from Chinese women. The genetic distribution of two CYP1A1 polymorphisms at MspI, Ile462Val and four CYP1B1 polymorphisms at Arg48Gly, Ala119Ser, Leu432Val, Asp449Asp were analyzed by polymerase chain reactionrestriction fragment length polymorphism and DNA sequencing method. Results All the SNPs showed polymorphisms in Chinese women. The genotype A/G and the allele G on Ile462Val was significantly different between uterine leiomyoma patients and controls (P<0.05). Conclusion These results suggest that the genotype of CYP1A1 Ile462Val was associated with the increased risk of uterine leiomyomas in Chinese women.

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Distribution of CYP1A1⁎2A polymorphism in adult patients with acute lymphoblastic leukemia in a Mexican population

Cited by 17 publications

References 14 publications

Role of glutathione-s-transferase and CYP1A1FNx012A polymorphisms in the therapy outcome of south Indian acute lymphoblastic leukemia patients

Role of glutathione-s-transferase and CYP1A1FNx012A polymorphisms in the therapy outcome of south Indian acute lymphoblastic leukemia patients

Polymorphisms in CYP1A1 and Ethnic-Specific Susceptibility to Acute Lymphoblastic Leukemia in Children

CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women

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