Distribution of Cortisol in Human Plasma in vitro: Equilibrium Solutions for Free Cortisol Using Equations of Mass Conservation and Mass Action
Richard I. Dorin,
Clifford R. Qualls
Abstract:Cortisol is secreted by the human adrenal cortex and circulates in plasma as free or protein-bound cortisol. Corticosteroid binding globulin (CBG) and albumin are the principal binding proteins (BPs) for cortisol in human plasma. Plasma concentrations of total cortisol (sum of protein-bound and free cortisol) are typically measured in vitro. Determination of free cortisol adds clinical and diagnostic value to total cortisol concentration. However, direct measurement of free cortisol concentrations involves lab… Show more
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