Distribution of corticotropin-releasing factor in the tree shrew brain

Shu, Yu-Mian; Ni, Rong-Jun; Sun, Yunjun; Fang, Hui; Zhou, Jiang‐Ning

doi:10.1016/j.brainres.2015.06.004

Cited by 12 publications

(10 citation statements)

References 55 publications

(56 reference statements)

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“…For fibers, CRF is enriched in the lateral septal region and throughout the external layer of the median eminence [48]. The distribution pattern has later been repetitively confirmed by different methods, including in situ hybridization in voles [49], immunohistochemical labeling by CRF specific polyclonal antibody in mice, rats [50], and tree shrews [51], and immunofluorescence by anti-GFP antibody targeting CRF-Venus fusion protein in the knock-in mice [52]. These studies demonstrate that the expression pattern of CRFs is conserved among species.…”

Section: Central Expression Of Crfs and Crf Receptorsmentioning

confidence: 84%

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2017

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Section: Central Expression Of Crfs and Crf Receptorsmentioning

confidence: 84%

“…CRFs are apparently localized in both cell bodies and the fibers of the central nuclei of the amygdala among different species [48][49][50][51][52]. In the CeA, CRF is co-localized with GABA [52].…”

Section: Central Expression Of Crfs and Crf Receptorsmentioning

confidence: 99%

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2017

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“…Previous papers have identified and named some subregions of the tree shrew cerebellum and their connections (Haines, ; Haines et al, ; Haines & Patrick, ; Haines & Whitworth, ; Shu et al, ; Sillitoe et al, ). Although the Tigges and Shantha's atlas includes plates of the cerebellum, only coronal sections are provided and their labeling of cerebellum is rudimentary (Tigges & Shantha, ).…”

Section: Discussionmentioning

confidence: 99%

“…The sections were treated with Nissl staining and AChE histochemistry to designate the neuroanatomical structures of the tree shrew cerebellum. In this atlas, we have mainly relied upon our previous papers (Ni et al, ; Shu, Ni, Sun, Fang, & Zhou, ; Zhou & Ni, ) and comparisons between series of our staining sections in tree shrews and those shown in publications describing cerebellar structures in other mammals (Franklin & Paxinos, ; Palazzi & Bordier, ; Paxinos, Huang, & Toga, ; Paxinos & Watson, ). We also referred to several publications and papers that describe the precise positions of tree shrew cerebellar structures (Haines, ; Haines & Patrick, ; Haines & Pearson, ; Haines, Sowa, & Dietrichs, ; Haines & Whitworth, ; Patrick & Haines, ; Sillitoe et al, ; Ware & Mufson, ; Whitworth, Haines, & Patrick, ).…”

Section: Methodsmentioning

confidence: 99%

The tree shrew cerebellum atlas: Systematic nomenclature, neurochemical characterization, and afferent projections

Huang

Luo

et al. 2018

J of Comparative Neurology

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The cerebellum is involved in the control of movement, emotional responses, and reward processing. The tree shrew is the closest living relative of primates. However, little is known not only about the systematic nomenclature for the tree shrew cerebellum but also about the detailed neurochemical characterization and afferent projections. In this study, Nissl staining and acetylcholinesterase histochemistry were used to reveal anatomical features of the cerebellum of tree shrews (Tupaia belangeri chinensis). The cerebellar cortex presented a laminar structure. The morphological characteristics of the cerebellum were comprehensively described in the coronal, sagittal, and horizontal sections. Moreover, distributive maps of calbindin-immunoreactive (-ir) cells in the Purkinje cell layer of the cerebellum of tree shrews were depicted using coronal, sagittal, and horizontal schematics. In addition, 5th cerebellar lobule (5Cb)-projecting neurons were present in the pontine nuclei, reticular nucleus, spinal vestibular nucleus, ventral spinocerebellar tract, and inferior olive of the tree shrew brain. The anterior part of the paramedian lobule of the cerebellum (PMa) received mainly strong innervation from the lateral reticular nucleus, inferior olive, pontine reticular nucleus, spinal trigeminal nucleus, pontine nuclei, and reticulotegmental nucleus of the pons. The present results provide the first systematic nomenclature, detailed atlas of the whole cerebellum, and whole-brain mapping of afferent projections to the 5Cb and PMa in tree shrews. Our findings provide morphological support for tree shrews as an alternative model for studies of human cerebellar pathologies.

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“…35 36 42 neurons are also broadly distributed in other brain regions, including the inferior olivary 43 nucleus, Barrington's nucleus, pontine tegmentum, cerebral cortex, hippocampus, and 44 central amygdala. Depending on the region-specific somatic locations, CRH neurons 45 participate in various functional activities, such as learning memory, synaptic plasticity, 46 food intake and drug addiction, as well as anxiety-like and depression-like behaviors 47 Charlton et al, 1987;Cummings, 1989;Delville et al, 1992;Foote and Cha, 1988; 51 Merchenthaler, 1984;Shu et al, 2015). However, data from these studies have mainly been 52 acquired from histological imaging and through manual reconstruction and counting of 53 labeled neurons, which is time-consuming, limits further systematic analysis, and can 54 introduce biases and/or artifacts.…”

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Visualizing dendritic characteristics of corticotropin-releasing hormone neurons at single-cell resolution in the whole mouse brain

Wang

Shan

et al. 2020

Preprint

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22Corticotropin-releasing hormone (CRH) is an important neuromodulator with wide 23 distribution in the brain. Here, we screened the CRH-IRES-Cre;Ai32 mouse line to reveal 24 the morphologies of individual CRH neurons throughout the mouse brain by using 25 fluorescence micro-optical sectioning tomography (fMOST) system. Diverse dendritic 26 morphologies and projection fibers were found in various brain regions. Reconstructions 27 showed hypothalamic CRH neurons had the smallest somatic volumes and simplest 28 dendritic branches, and CRH neurons in several regions shared a bipolar morphology. 29 Further investigations in the medial prefrontal cortex unveiled somatic depth-dependent 30 morphologies that exhibited three types of connections and CRH neurons in the anterior 31 parvicellular area of hypothalamus had fewer and smaller Herring bodies whereas in the 32 periventricular area had more and larger Herring bodies that were present within fibers 33 projecting to the third ventricle. Our findings provide the most comprehensive intact 34 morphologies of CRH neurons throughout the mouse brain that is currently available. 35 36 42 neurons are also broadly distributed in other brain regions, including the inferior olivary 43 nucleus, Barrington's nucleus, pontine tegmentum, cerebral cortex, hippocampus, and 44 central amygdala. Depending on the region-specific somatic locations, CRH neurons 45 participate in various functional activities, such as learning memory, synaptic plasticity, 46 food intake and drug addiction, as well as anxiety-like and depression-like behaviors 47 Charlton et al., 1987;Cummings, 1989;Delville et al., 1992;Foote and Cha, 1988; 51 Merchenthaler, 1984;Shu et al., 2015). However, data from these studies have mainly been 52 acquired from histological imaging and through manual reconstruction and counting of 53 labeled neurons, which is time-consuming, limits further systematic analysis, and can 54 introduce biases and/or artifacts. Recently, genetically modified mouse models have been 55 developed to identify the whole-brain distributions of CRH neurons (Itoi et al., 2014; Kono 56 et al., 2017; Peng et al., 2017; Wamsteeker Cusulin et al., 2013), which has significantly 57 advanced our understanding of the morphological features of CRH neurons in the rodent 58 brain (De Francesco et al., 2015; Garcia et al., 2016; Huang et al., 2013; Nguyen et al., 59 2016). Advances in whole-brain optical imaging techniques, such as fluorescence micro-60 optical sectioning tomography (fMOST) (Gong et al., 2016; Gong et al., 2013; Ragan et 61 al., 2012; Zheng et al., 2013), have made it feasible to further quantify cellular distributions 62 and to morphologically reconstruct cells at the whole-brain level. The precision of imaging 63 via fMOST can reveal complex fiber orientations, and can even distinguish individual 64 dendrites. Such quantitative three-dimensional (3D) neuronal morphologies obtained at a 65 brain-wide scale can provide highly accurate arborization details and comprehensive 66 mapping of...

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Distribution of corticotropin-releasing factor in the tree shrew brain

Cited by 12 publications

References 55 publications

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The tree shrew cerebellum atlas: Systematic nomenclature, neurochemical characterization, and afferent projections

Visualizing dendritic characteristics of corticotropin-releasing hormone neurons at single-cell resolution in the whole mouse brain

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