Distribution of Cortical Benzodiazepine Receptor Binding in Right-Handed Healthy Humans: A Voxel-Based Statistical Analysis of Iodine 123 Iomazenil SPECT with Partial Volume Correction

Kato, Hirohisa; Shimosegawa, Eku; Isohashi, Kayako; Kimura, Nobuyo; Kazui, Hiroaki; Hatazawa, Jun

doi:10.3174/ajnr.a3005

Cited by 6 publications

(6 citation statements)

References 23 publications

(28 reference statements)

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“…To generate VOI for GM and/or WM, binary mask images for the GM and/or WM were created using the segmented images in the native space of each subject. The binary mask image boundary was set at 35% of the maximum GM or WM concentration as described in previous studies [22], [23].…”

Section: Methodsmentioning

confidence: 99%

11C-Acetate PET Imaging in Patients with Multiple Sclerosis

et al. 2014

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BackgroundActivation of glial cells is a cardinal feature in multiple sclerosis (MS) pathology, and acetate has been reported to be selectively uptaken by astrocytes in the CNS. The aim of this study was to investigate the efficacy of PET with 11C-acetate for MS diagnosis.Materials and MethodsSix patients with relapsing-remitting MS and 6 healthy volunteers (HV) were enrolled. The 11C-acetate brain uptake on PET was measured in patients with MS and HV. Volume-of-interest analysis of cerebral gray and white matter based on the segmentation technique for co-registered MRI and voxel-based statistical parametric analysis were performed. Correlation between 11C-acetate uptake and the lesion number in T1- and T2- weighted MR images were also assessed.ResultsThe standardized uptake value (SUV) of 11C-acetate was increased in both white and gray matter in MS patients compared to HV. Voxel-based statistical analysis revealed a significantly increased SUV relative to that in the bilateral thalami (SUVt) in a broad area of white matter, particularly in the subcortical white matter of MS patients. The numbers of T2 lesions and T1 black holes were significantly correlated with SUV of 11C-acetate in white and gray matter.ConclusionsThe 11C-acetate uptake significantly increased in MS patients and correlated to the number of MRI lesions. These preliminary data suggest that 11C-acetate PET can be a useful clinical examination for MS patients.

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Section: Methodsmentioning

confidence: 99%

11C-Acetate PET Imaging in Patients with Multiple Sclerosis

et al. 2014

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“…PVC of SPECT images was performed using a method similar to that described for our previous study. [4][5][6] 3D T1-weighted MR images were first resliced into transaxial sections, segmented into grey matter and other compartments, and then spatially normalized using the "new segment" function of Statistical Parametric Mapping (SPM) 8 (Wellcome Department of Imaging Neuroscience: http://www.fil.ion.ucl.ac.uk/spm/). By this process, segmented tissue maps, including grey and white matter maps in original coordinates, normalized segmented tissue maps, and spatial normalization matrices were generated.…”

Section: Partial Volume Effect Correction (Pvc) Of Spectmentioning

confidence: 99%

“…Correlation analyses between the SPECT images and the cognitive test scores were also performed using SPM8. The resultant T-score maps obtained from the SPM analysis were analyzed based on the Automated Anatomical Labeling (AAL) 9 using an in-house tool, 5,10 in order to evaluate the distribution and extension of regions with significant changes in 123 I-IMZ uptake.…”

Section: Spm Analysismentioning

confidence: 99%

Impaired neuronal integrity in traumatic brain injury detected by ¹²³I-iomazenil single photon emission computed tomography and MRI

Kato

Nakagawara

Hachisuka

et al. 2022

J Cereb Blood Flow Metab

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This study was aiming at investigating the extent of neuronal damage in cases of traumatic brain injury (TBI) with diffuse axonal injury (DAI) using 123I-iomazenil(IMZ) SPECT and MRI. We compared the findings in 31 patients with TBI without any major focal brain lesions and 25 age-matched normal controls. Subjects underwent 123I-IMZ SPECT and MRI, and also assessment by cognitive function tests. The partial volume effect of 123I-IMZ SPECT was corrected using MRI. In the patients with TBI, decreased spatial concentration of 123I-IMZ binding was detected in the medial frontal/orbitofrontal cortex, posterior cingulate gyrus, cuneus, precuneus, and superior region of the cerebellum. ROC analysis of 123I-IMZ SPECT for the detection of neuronal injury showed a high diagnostic ability of 123I-IMZ binding density for TBI in these areas. The decreased 123I-IMZ uptake density in the cuneus and precuneus was associated with cognitive decline after the injury. In the patients with TBI, brain atrophy was detected in the frontal lobe, anterior temporal and parietal cortex, corpus callosum, and posterior part of the cerebellum. Evaluation of the neuronal integrity by 123I-IMZ SPECT and MRI provides important information for the diagnosis and pathological interpretation in cases of TBI with DAI.

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“…There are several reports on age-related changes occurring in cerebral GABAA-R distribution in rats [11][12][13], but the results are inconsistent. Regarding the human brain, there are few studies related to these changes [14,15]. Therefore, to accurately evaluate functional abnormalities associated with various neurological and psychiatric diseases, it is essential to clarify age-related changes in GABAA-R distribution in normal subjects.…”

Section: Introductionmentioning

confidence: 99%

Age-related increase in GABAA receptor distribution in the prefrontal cortex

Tobinaga

Suzuki

Fujinaka

et al. 2019

Journal of Clinical Neuroscience

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Profound insight into age-related changes in c-aminobutyric acid type A receptor (GABAA-R) distribution using iodine-123-iomazenil single photon emission computed tomography (IMZ-SPECT) can contribute to accurate in vivo evaluation. We evaluated the age-related changes in prefrontal cortex (PFC), which is the key region involved in various neurological and psychiatric diseases. In this study, IMZ-SPECT imaging data of 21 healthy males with an age range of 22-59 (mean, 38 ± 12) years were analyzed using threedimensional stereotactic surface projection (3D-SSP). The Z-score images of the younger group (age < 40, n = 11) and the older group (age ! 40, n = 10) were compared. Subsequently, the mean RI-count ratios calculated for each Brodmann area (BA) by stereotactic extraction estimation method were compared between these groups. Thereafter, linear regression analysis between age and RI-count ratio was performed for all enrolled subjects. In the result, IMZ accumulation increased in bilateral BA10, 11, and the BA47 (left hemisphere) in the older group compared with the younger group. Furthermore, regression analysis demonstrated a significant positive correlation between age and RI-count ratio in these areas.Our findings indicate that GABAA-R distribution in the PFC relatively increases with age. Therefore, we concluded that the age-related changes should be considered to accurately evaluate pathophysiology of neurological and psychiatric diseases.

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Distribution of Cortical Benzodiazepine Receptor Binding in Right-Handed Healthy Humans: A Voxel-Based Statistical Analysis of Iodine 123 Iomazenil SPECT with Partial Volume Correction

Cited by 6 publications

References 23 publications

11C-Acetate PET Imaging in Patients with Multiple Sclerosis

11C-Acetate PET Imaging in Patients with Multiple Sclerosis

Impaired neuronal integrity in traumatic brain injury detected by ¹²³I-iomazenil single photon emission computed tomography and MRI

Age-related increase in GABAA receptor distribution in the prefrontal cortex

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Distribution of Cortical Benzodiazepine Receptor Binding in Right-Handed Healthy Humans: A Voxel-Based Statistical Analysis of Iodine 123 Iomazenil SPECT with Partial Volume Correction

Cited by 6 publications

References 23 publications

11C-Acetate PET Imaging in Patients with Multiple Sclerosis

11C-Acetate PET Imaging in Patients with Multiple Sclerosis

Impaired neuronal integrity in traumatic brain injury detected by 123I-iomazenil single photon emission computed tomography and MRI

Age-related increase in GABAA receptor distribution in the prefrontal cortex

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Impaired neuronal integrity in traumatic brain injury detected by ¹²³I-iomazenil single photon emission computed tomography and MRI