Distribution of Conjunctival HLA-DR Expression and the Pathogenesis of Damage in Early Dry Eyes

Rolando, Maurizio; Barabino, Stefano; Mingari, C.; Moretti, S; Giuffrida, Sebastiano; Calabria, G.

doi:10.1097/01.ico.0000157421.93522.00

Cited by 90 publications

(52 citation statements)

References 20 publications

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“…Moreover, the impression cytology and brush cytology samples can also be used to perform immunohistochemical staining, enzyme-linked immunosorbent assay, flow cytometry, and mRNA expression analysis. 9,10,29,30 Therefore, they are also useful to monitor the pathologic progress in cGVHD-related dry eye disease and helpful for investigating the etiology of cGVHD-related dry eye disease.…”

Section: Discussionmentioning

confidence: 99%

Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eye

Wang

Ogawa

Doğru

et al. 2009

Bone Marrow Transplant

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We evaluated ocular surface alterations in allogeneic hematopoietic stem cell transplantation (HSCT) recipients with or without chronic GVHD-related dry eye in a prospective study. Fifty eyes of 25 post-HSCT patients and 28 eyes of 14 age-matched healthy controls were included. Meibomian gland (MG) obstruction, tear evaporation rate, corneal sensitivity (CS), Schirmer test-I, tear break-up time (BUT) and ocular surface vital staining were examined. Conjunctival impression and brush cytology specimens were collected to evaluate the goblet cell density (GCD) and the inflammatory cell numbers. Obvious MG obstruction, decreased CS and enhanced tear evaporation rate were found in post-HSCT patients compared with normal controls. In addition, decreased conjunctival GCD, increased conjunctival squamous metaplasia and inflammatory cells were noted in cGVHD-related dry eyes compared with normal controls and post-HSCT without dry eye subjects. Furthermore, the conjunctival inflammatory cells were significantly higher in severe dry eyes compared with mild dry eyes (P ¼ 0.03). We found comprehensive ocular surface alteration in post-HSCT patients, regardless of whether they had cGVHD-related dry eye or not. The results suggest that the extent of inflammatory process seems to have a pivotal role in the outcome of the cGVHD-related dry eye.

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Section: Discussionmentioning

confidence: 99%

Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eye

Wang

Ogawa

Doğru

et al. 2009

Bone Marrow Transplant

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“…HLA-DR is a MHC class II antigen whose expression by conjunctival epithelial cells has been shown to correlate with the severity of dry eye, as characterised by vital staining and Schirmer test [31,32,33]. Contact lens wearers with dry eye show greater expression of HLA-DR compared to non-dry eye wearers [34].…”

Section: Sub-clinical Inflammation Has Been Demonstrated In Contact Lmentioning

confidence: 99%

Oral omega-6 essential fatty acid treatment in contact lens associated dry eye

Kokke

Morris

Lawrenson

2008

Contact Lens and Anterior Eye

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This is the unspecified version of the paper.This version of the publication may differ from the final published version. and also a significant improvement in overall lens comfort at 6 months (p<0.01). Permanent repository linkTear meniscus height was increased in the EPO group at 6 months relative to baseline (p<0.01), although all other objective signs were unchanged. Conclusion:This study provides evidence for a beneficial effect of particular orally administered omega-6 fatty acids in alleviating dry eye symptoms and improving overall lens comfort in patients suffering from contact lens associated dry eye.

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“…It is characterized by focal lymphocytic infiltration of these secretory glands (dacryoadenitis and sialoadenitis), hypergammaglobulinaemia and production of autoantibodies, including anti-SS-A/Ro, anti-SS-B/La and anti-muscarinic type-3 acetylcholine receptor (M3R) [1,2]. Immunopathological features of the conjunctiva in Sjögren's syndrome include increased expression of cytokines, chemokines and immune activation and adhesion molecules [3,4]. An increase in the CD4/ CD8 T cell ratio in the conjunctiva has also been observed [5].…”

Section: Introductionmentioning

confidence: 99%

Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice

Yoon

Paiva

et al. 2008

Journal of Autoimmunity

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The non-obese diabetic (NOD) mouse is prone to develop autoimmune disease, including Sjögren's syndrome. The purpose of this study was to determine if desiccating environmental stress exacerbates the development of Sjögren's syndrome-like lacrimal keratoconjunctivitis in the NOD.B10.H2 b mouse. Four-week-old male mice were used as young controls. Sixteen-week-old male mice were untreated or subjected to desiccating stress with a fan alone or with a fan plus subcutaneous injections of the anticholinergic agent scopolamine for 5 or 10 days to inhibit tear production. Mice spontaneously developed Sjögren's syndrome-like lacrimal keratoconjunctivitis as they aged. Desiccating stress increased CD4+ and CCR5+ cells and decreased CD8+ cells in the conjunctival epithelium and lacrimal gland. Intraepithelial γδ T cells significantly decreased after 5 days and returned to baseline levels after 10 days in both groups exposed to desiccating stress. These immunopathological changes were accompanied by a decrease in conjunctival goblet cell density. Greater matrix metalloproteinase-9 production, gelatinase activity and loss of epithelial cell membrane CD25 immunoreactivity was noted in the ocular surface epithelia of stressed mice. These findings indicate that desiccating environmental stress aggravates Sjögren's syndrome-like lacrimal keratoconjunctivitis in the NOD mouse which has defective immunoregulation.

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Distribution of Conjunctival HLA-DR Expression and the Pathogenesis of Damage in Early Dry Eyes

Cited by 90 publications

References 20 publications

Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eye

Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eye

Oral omega-6 essential fatty acid treatment in contact lens associated dry eye

Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice

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