Distribution of collagens type I, type III and type V in the pancreas of rat, dog, pig and man

Deijnen, J. H. M. van; Suylichem, P.T.R. van; Wolters, G. H. J.; Schilfgaarde, R. van

doi:10.1007/s004410050138

Cited by 29 publications

(43 citation statements)

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“…upon contact with connective tissue in the subendothelial matrix or with a biomaterial (e. g. PVC or titanium) which binds fibrinogen to the surface [9]. When islets are infused into the bloodstream via the portal vein, a similar reaction probably occurs: collagen types I, 111, IV, and V have been reported to surround human islets, and collagen is known to mediate platelet binding and activation [20,211. The a,B, glycoprotein Ia-IIa complex, CD36, P65, and GPVI have all been proposed as platelet collagen receptors [ 101.…”

Section: The Role Of Platelets In Ibmirmentioning

confidence: 96%

Isolated Human Islets Trigger an Instant Blood Mediated Inflammatory Reaction: Implications for Intraportal Islet Transplantation as a Treatment for Patients with Type 1 Diabetes

Bennet

Groth

Larsson

et al. 2000

Upsala Journal of Medical Sciences

318

251

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Islet transplantation offers a logical means to treat insulin-dependent diabetes. However, for reasons poorly understood, the clinical results with islet transplantation have been vastly inferior to those obtained with whole organ pancreas transplantation. The conventional technique for transplanting isolated islets is by intraportal injection, with the islets being trapped in the liver. Human islets exposed to human blood trigged an "instant blood mediated inflammatory reaction", IBMIR, characterised by platelet consumption, and activation of the coagulation and complement systems. The islets became surrounded by clots and infiltrated with leukocytes, and there was evidence of islet damage as reflected in insulin dumping. When heparin and a complement inhibitor (SCRI), was added to the system, IBMIR was suppressed and islet damage reduced. After intraportal pig-to-pig islet intraportal allotransplantation similar morphological changes was found, corroborating the in vitro findings. Thus, IBMIR inflicts a significant damage to human islets exposed to human blood and IBMIR will also, most likely, enhance the subsequent specific, cell mediated, rejection. Platelet and complement activation seem to be the most important factors in the pathogenesis of IBMIR. The results presented strongly suggest that IBMIR observed both in vitro and in vivo when isolated islets come in contact with blood could provide an explanation for the unsatisfactory results seen in clinical islet allotransplantation.

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Section: The Role Of Platelets In Ibmirmentioning

confidence: 96%

Isolated Human Islets Trigger an Instant Blood Mediated Inflammatory Reaction: Implications for Intraportal Islet Transplantation as a Treatment for Patients with Type 1 Diabetes

Bennet

Groth

Larsson

et al. 2000

Upsala Journal of Medical Sciences

318

251

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“…Each receptor may recognize multiple ligands and each matrix protein may contain multiple cell binding domains, with each ligand–receptor binding combination potentially producing different cellular outcomes. The receptor and matrix compositions of islets also appear to vary significantly between developing and mature tissues (49), as well as between species (106,107,110). In addition, there are numerous nonendocrine cells in close proximity to islets that can complicate results.…”

Section: Islet-ecm Interactionsmentioning

confidence: 99%

“…BM is a specific type of ECM associated with epithelium and endothelium, and consists of distinct layers of laminin (LM) and nonfibrillar collagen (Coll) linked by specific interactions with nidogen/entactin (47). The peripheral ECM of mature human islets has most often been reported to be composed of LM (73,74,87,106,108,110) and Coll-IV (73,74,106,110), although fibronectin (FN) (73,74,87) and Coll-I (73,74, 107), Coll-III (73,74,107), Coll-V (107), and Coll-VI (74) have also been detected. Hughes et al recently performed a quantitative evaluation of the peripheral matrix composition of human islets and reported that the prevalence of Coll-VI was significantly greater than that of Coll-I or Coll-IV (42).…”

Section: Islet Ecm Compositionmentioning

confidence: 99%

Extracellular Matrix in Pancreatic Islets: Relevance to Scaffold Design and Transplantation

Kaufman²,

2009

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Intrahepatic islet transplantation provides a potentially more benign alternative to pancreatic transplantation. However, islet transplants are associated with limited engraftment potential. This inefficiency is likely at least partially attributable to the isolation process, which removes islets from their native environment. Isolation not only disrupts the internal vascularization and innervation of islets, but also fundamentally changes interactions between islet cells and macromolecules of the extracellular matrix (ECM). Signaling interactions between islet cells and ECM are known to regulate multiple aspects of islet physiology, including survival, proliferation, and insulin secretion. Although it is highly likely that disruptions to these interactions during isolation significantly affect transplant outcomes, the true implications of these conditions are not well understood. The following article reviews current understandings and uncertainties in islet-ECM interactions and explains their potential impact on posttransplant engraftment. Topics covered include matrix and receptor compositions in native islets, effects of isolation and culture on islet-ECM interactions, and potential for postisolation restoration of islet-ECM interactions. Greater understanding in these areas may help to reduce isolation and transplantation stresses and improve islet engraftment.

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“…Коллагены типа I, IV, V и VI при-сутствуют на границе экзокринно-эндокринных клеточных взаимодействий и в непосредственной близости к внутриостровковым эндотелиальным клеткам [77]. Коллагены I, V, VI типов являются на-иболее распространенными изоформами в пределах островково-экзокринного интерфейса поджелудоч-ной железы человека с лишь слабой экспрессией коллагена IV типа, хотя его присутствие сильно вы-ражено в эпителиальной основе плодной ПЖ [78].…”

Section: примеры тканеинженерных конструкций поджелудочной железыunclassified

Prospects of Application of Tissue-Engineered Pancreatic Constructs in the Treatment of Type 1 Diabetes

Skaletskaya

Skaletskiy

Sevastianov

2017

RJTAO

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ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва, Российская Федерация Наиболее эффективным методом лечения сахарного диабета 1-го типа по-прежнему является аллотранс-плантация островков поджелудочной железы, которая при сочетании благоприятных условий (достаточ-ное количество выделенных островков, удачная комбинация иммуносупрессивных препаратов) способна достичь инсулиннезависимости реципиентов на протяжении нескольких лет. Однако постоянный дефи-цит донорских поджелудочных желез и ограниченность выживания островков в организме реципиента не позволяют увеличить количество таких трансплантаций и повысить их эффективность. В настоящем обзоре дан критический анализ работ российских и зарубежных авторов по созданию тканеинженерных конструкций поджелудочной железы, направленных на решение трех главных проблем трансплантации островков поджелудочной железы: 1) дефицит донорского материала; 2) необходимость проведения им-муносупрессивной терапии; 3) непродолжительность выживания и функциональной активности переса-женных островков.Ключевые слова: сахарный диабет 1-го типа, трансплантация, островки, поджелудочная железа, тканеинженерные конструкции. Allotransplantation of pancreatic islets remains the most effective method of treatment of diabetes mellitus type 1 being capable under combination of favorable conditions (suffi cient number of isolated islets, effective combination of immunosuppressive drugs) to reach the recipients' insulin independence for several years. However, the overwhelming shortage of donor pancreas and limited post-transplantation islet survival do not allow increasing the number of such transplants and their effectiveness. This review presents a critical analysis of the work done by Russian and foreign authors onto creation of tissue-engineered pancreatic constructs that may lead to the resolution of the three main pancreatic islet transplantation issues: 1) lack of donor material; 2) necessity of immunosuppressive therapy; 3) limited survival and functional activity of the islet. PROSPECTS OF APPLICATION OF TISSUE-ENGINEERED PANCREATIC CONSTRUCTS IN THE TREATMENT Key words: diabetes mellitus type 1, transplantation, islets, pancreas, tissue-engineered constructs.Для корреспонденции: Скалецкий Николай Николаевич. Адрес: 123182, Москва, ул. Щукинская, д. 1. В настоящее время золотым стандартом лечения сахарного диабета 1-го типа по-прежнему является введение экзогенного инсулина в ответ на повышен-ный уровень глюкозы в крови. Создание синтети-ческих аналогов инсулина, их введение с помощью носимых дозаторов, возможность регулярного кон-

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Distribution of collagens type I, type III and type V in the pancreas of rat, dog, pig and man

Cited by 29 publications

References 0 publications

Isolated Human Islets Trigger an Instant Blood Mediated Inflammatory Reaction: Implications for Intraportal Islet Transplantation as a Treatment for Patients with Type 1 Diabetes

Isolated Human Islets Trigger an Instant Blood Mediated Inflammatory Reaction: Implications for Intraportal Islet Transplantation as a Treatment for Patients with Type 1 Diabetes

Extracellular Matrix in Pancreatic Islets: Relevance to Scaffold Design and Transplantation

Prospects of Application of Tissue-Engineered Pancreatic Constructs in the Treatment of Type 1 Diabetes

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