Distribution of CD4+ and CD8+ T cells in tumor islets and stroma from patients with non-small cell lung cancer in association with COPD and smoking

Jackutė, Jurgita; Žemaitis, Marius; Pranys, Darius; Šitkauskienė, Brigita; Miliauskas, Skaidrius; Bajoriūnas, Vytis; Sakalauskas, Raimundas

doi:10.1016/j.medici.2015.08.002

Cited by 21 publications

(17 citation statements)

References 51 publications

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“…It is known that tobacco smoke stimulates the infiltration of the damaged tissue by a variety of inflammatory immune cells, including neutrophils, macrophages, CD4 + , CD8 + , and B cells and infiltration of dendritic cells and natural killer cells at smaller numbers [ 37 ]. In agreement with these data, our previous study showed a greater number of total and tumor stroma-infiltrating CD4 + and CD8 + T cells in smoking NSCLC patients compared with non-smokers [ 38 ]. Macrophages accumulate in the areas of lung destruction; therefore, their numbers are increased in the lungs of healthy smokers and individuals with COPD.…”

Section: Discussionsupporting

confidence: 87%

Distribution of M1 and M2 macrophages in tumor islets and stroma in relation to prognosis of non-small cell lung cancer

et al. 2018

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BackgroundNon-small cell lung cancer (NSCLC) remains the most common cause of cancer related death worldwide. Tumor-infiltrating macrophages are believed to play an important role in growth, progression, and metastasis of tumors. In NSCLC, the role of macrophages remains controversial; therefore, we aimed to evaluate the distribution of macrophages (M1 and M2) in tumor islets and stroma and to analyze their relations to patients’ survival.MethodsLung tissue specimens from 80 NSCLC patients who underwent surgical resection for NSCLC (pathological stage I-III) and 16 control group subjects who underwent surgery because of recurrent spontaneous pneumothorax were analyzed. Immunohistochemical double staining of CD68/iNOS (markers for M1 macrophages) and CD68/CD163 (markers for M2 macrophages) was performed and evaluated in a blinded manner. The numbers of M1 and M2 macrophages in tumor islets and stroma were counted manually.ResultsPredominant infiltration of M1 and M2 macrophages was observed in the tumor stroma compared with the tumor islets. M2 macrophages predominated over M1 macrophages in the tumor tissue. Tumor islets-infiltrating M1 macrophages and the number of total tumor-infiltrating M2 macrophages were independent predictors of patients survival: high infiltration of M1 macrophages in tumor islets was associated with increased overall survival in NSCLC (P < 0.05); high infiltration of total M2 macrophages in tumor (islets and stroma) was associated with reduced overall survival in NSCLC (P < 0.05).ConclusionsThis study demonstrated that high infiltration of M1 macrophages in the tumor islets and low infiltration of total tumor-infiltrating M2 macrophages were associated with improved NSCLC patients’ survival.Trial registrationClinicalTrials.gov NCT01955343, registered on September 27, 2013

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Section: Discussionsupporting

confidence: 87%

Distribution of M1 and M2 macrophages in tumor islets and stroma in relation to prognosis of non-small cell lung cancer

et al. 2018

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“…Genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) which predispose to increased susceptibility to COPD and lung cancer such as SERPIN2, HHIP, FAM13A, IREB2, CHRNA3 and CHRNA5 2, 11 . Other studies also showed that inflammatory response factors, aberrant NF-κB activation and cytokine release, and high levels of CD8+ T cells mediated the link between COPD and lung cancer 12, 13 .…”

Section: Introductionmentioning

confidence: 97%

Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD

Xiao

Hui

et al. 2017

Sci Rep

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Both chronic Obstruction Pulmonary Disease (COPD) and lung cancer are leading causes of death globally. Although COPD and lung cancer coexist frequently, it is unknown whether lung cancer patients with COPD harbor distinct genomic characteristics compared to those without COPD. In this study, we retrospectively analyzed genomic sequencing data from 272 patients with lung adenocarcinoma (LUAD) and compared the genetic alterations in LUAD patients with and without COPD. Integrative analysis of whole-genome and exome sequencing data revealed that COPD and non-COPD groups showed high concordance in mutational burden and spectra. Notably, we also found that EGFR mutations were more prevalent in LUAD patients without COPD, whereas mutated LRP1B was more frequently observed in LUAD patients with COPD. In addition, multi-variable analysis with logistic regression demonstrated that mutation of LRP1B was a predictive marker for the presence of COPD in the patients with LUAD. Our analysis demonstrated for the first time the high concordance in genomic alterations between the tumors from LUAD patients with and without COPD. We also identified higher prevalence of LRP1B among the LUAD patients with COPD, which might help understand the underlying mechanisms which link COPD and lung cancer.

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“…CD4 + /CD8 can reflect the immune balance of an organism, if the ratio is low, it means that body immune function is decreasing and may increase tumor proliferation. Of note, a low ratio is commonly regarded as the index for severe disease or a poor prognosis (21)(22)(23). In the present study, CD3 + , CD4…”

Section: Discussionmentioning

confidence: 50%

Effects of laparoscopic radical gastrectomy and the influence on immune function and inflammatory factors

Ma¹,

Bao²,

Gu³

2016

Experimental and Therapeutic Medicine

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Distribution of CD4+ and CD8+ T cells in tumor islets and stroma from patients with non-small cell lung cancer in association with COPD and smoking

Cited by 21 publications

References 51 publications

Distribution of M1 and M2 macrophages in tumor islets and stroma in relation to prognosis of non-small cell lung cancer

Distribution of M1 and M2 macrophages in tumor islets and stroma in relation to prognosis of non-small cell lung cancer

Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD

Effects of laparoscopic radical gastrectomy and the influence on immune function and inflammatory factors

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