Distribution of blood concentrations of persistent organic pollutants in a representative sample of the population of Barcelona in 2006, and comparison with levels in 2002

Porta, Miquel; López, Tomás; Gasull, Magda; Rodríguez-Sanz, Maica; Garí, Mercè; Pumarega, José; Borrell, Carme; Grimalt, Joan O.

doi:10.1016/j.scitotenv.2012.02.001

Cited by 71 publications

(42 citation statements)

References 57 publications

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“…A study from the US with slightly lower median serum PCB concentrations compared to the present study (Table 6) found downward trends of PCB74, PCB118, PCB138, PCB153, and PCB180 in US pregnant women between 2008-2012(Zota et al 2013.…”

Section: Temporal Trends Of Lipophilic Popscontrasting

confidence: 67%

“…Several studies have reported that the lipophilic POP concentrations are associated with age (Fernandez-Rodriguez et al 2015;Long et al 2015;Medehouenou et al 2011;Porta et al 2012;Rylander et al 2012;Sandau et al 2000;Wolff et al 2005), BMI (Fernandez-Rodriguez et al 2015;Halldorsson et al 2008b;Medehouenou et al 2011;Porta et al 2012;Wolff et al 2005), smoking status (Deutch et al 2007(Deutch et al , 2003Fernandez-Rodriguez et al 2015;Wolff et al 2005), and gestational age at blood draw (Adetona et al 2013;Longnecker et al 1999). Hence, in the present study, the temporal trends were analyzed for the lipidcorrected crude data and upon adjustment for these potential confounders.…”

Section: Statisticsmentioning

confidence: 97%

“…The temporal changes of lipophilic POP concentrations have not been studied much in Europe in recent years, and to our knowledge, no time trend studies have been conducted in Denmark. The lipophilic POP concentrations in human serum may be dependent on factors such as age, body mass index (BMI), parity, and gender (Caspersen et al 2016;Fernandez-Rodriguez et al 2015;Long et al 2015;Medehouenou et al 2011;Porta et al 2012;Rylander et al 2012;Sandau et al 2000;Wolff et al 2005). Hence, it is important to control for these covariates when conducting a time trend study by e.g., selecting a homogenous population such as nulliparous pregnant women.…”

Section: Responsible Editor: Hongwen Sunmentioning

confidence: 99%

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Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011–2013

Bjerregaard-Olesen

Long

Ghisari

et al. 2017

Environ Sci Pollut Res

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The use of the lipophilic persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs) and several organochlorine pesticides (OCPs) has been prohibited for more than 30 years. In this study, we present the temporal trends of the lipophilic POP serum concentrations in Danish nulliparous pregnant women between 2011 and 2013. We randomly selected 197 pregnant women (gestational age 11-13) from the Aarhus Birth Cohort. The concentrations of the lipophilic POPs in the serum samples were analyzed using gas chromatography. The concentrations were corrected for total serum lipids. The statistical analysis was performed by regression analysis with adjustment for age, BMI, gestational age at blood draw, and smoking status. The serum concentrations of PCB 118, 138, 153, 156, 170, 180, 187, and hexachlorobenzen, trans-nonachlor, β-hexachlorocyclohexane (β-HCH), and p,p'-dichlorodiphenyldichloroethylene were lower in 2013 than in 2011. However, the oxychlordane concentration was lowest in 2011. The serum levels of most lipophilic POPs followed downward trends during the study period, which was expected, as these compounds has been banned for many years. The upward trend of oxychlordane was unexpected and presumably a chance finding.

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Section: Temporal Trends Of Lipophilic Popscontrasting

confidence: 67%

Section: Statisticsmentioning

confidence: 97%

Section: Responsible Editor: Hongwen Sunmentioning

confidence: 99%

See 1 more Smart Citation

Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011–2013

Bjerregaard-Olesen

Long

Ghisari

et al. 2017

Environ Sci Pollut Res

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“…Concentrations of PCB in human blood decreased about 34-56% from 2002 to 2006 with difference for age, body mass index, weight (Porta et al, 2012) …”

Section: Polychlorinated Biphenyls (Pcbs)mentioning

confidence: 99%

“…PCBs are also significantly decreased the concentrations in blood and human milk (Porta et al, 2012;Alivernini et al, 2011).…”

Section: Polychlorinated Biphenyls (Pcbs)mentioning

confidence: 99%

Old and New Air Pollutants: An Evaluation on Thirty Years Experiences

Ferrante¹,

Fiore²,

Conti³

et al. 2012

Air Pollution - A Comprehensive Perspective

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Dioxin-like rather than non-dioxin-like PCBs promote the development of endometriosis through stimulation of endocrine–inflammation interactions

Huang

Chen

et al. 2016

Arch Toxicol

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Polychlorinated biphenyls (PCBs) contain 209 congeners with various structure-activities. Exposure to PCBs was related to disorders of female reproduction. Endometriosis (EM) is an estrogen- and inflammation-dependent disease with high prevalence and severe health outcomes. Epidemiological studies have shown the effects of PCBs exposure on EM in regard to various structures of PCBs. However, little evidence is available from the toxicology considering the structure of PCBs. In the study, environmentally relevant concentrations of PCBs were used to treat primary cultured endometrial cells and an EM mouse model. Dioxin-like CB126, but not non-dioxin-like CB153, significantly enhanced 17β-estradiol (E2) biosynthesis in a dose-dependent manner. Among the genes related to estrogen metabolism, the level of 17β-hydroxysteroid dehydrogenase 7 (HSD17B7) showed significant increase following CB126 exposure. We further found that CB126 exposure decreased the methylation of the HSD17B7 promoter. Elevated expression of HSD17B7 was observed in the eutopic endometrium of EM patients. CB126 rather than CB153 triggered the inflammatory response by directly stimulating the secretion of inflammatory factors and indirectly reducing the level of lipoxin A (LXA). Furthermore, the inflammation enhanced the expression of HSD17B7. Antagonism of the aryl hydrocarbon receptor (AhR) diminished the effects induced by CB126. In vivo, the PCB-treated EM mouse model confirmed that CB126 rather than CB153 increased the levels of both E2 and inflammatory factors in peritoneal fluid and promoted the development of endometriotic lesions. In all, CB126, but not CB153, triggered EM development by stimulating estrogen biosynthesis, inflammation and their interactions and that these effects were mediated by the AhR receptor.

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Distribution of blood concentrations of persistent organic pollutants in a representative sample of the population of Barcelona in 2006, and comparison with levels in 2002

Cited by 71 publications

References 57 publications

Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011–2013

Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011–2013

Old and New Air Pollutants: An Evaluation on Thirty Years Experiences

Dioxin-like rather than non-dioxin-like PCBs promote the development of endometriosis through stimulation of endocrine–inflammation interactions

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