Distribution of BDNF and TrkB isoforms in growing antler tissues of red deer

Colitti, Monica

doi:10.1016/j.aanat.2017.05.007

Cited by 1 publication

(1 citation statement)

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“…Unfortunately, research on other neurotrophic factors in depression remains limited, with inconsistent findings. Peripheral blood samples, used in many previous studies (15), might not accurately reflect brain neurotrophic factor levels due to their widespread expression in various tissues (16)(17)(18). Investigating these factors directly within the brain is likely crucial for a deeper understanding of depression.…”

Section: Introductionmentioning

confidence: 99%

Epidermal Growth Factor in the Brain: A Promising Biomarker for Depression

Xu,

Lyu,

Chen

et al. 2024

Preprint

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BackgroundThis study aimed to examine the neurotrophic factors secreted from brain in depression by analyzing astrocyte-derived extracellular vesicles (ADEVs) isolated from plasma, and to explore the causal relationship between the expression of neurotrophic factors in the brain and depression.MethodsA total of 40 patients with treatment-resistant depression (TRD) and 35 matched healthy controls (HCs) were recruited at baseline, and 34 TRD patients completed the post-electroconvulsive therapy (ECT) visits. The concentrations of five neurotrophic factors in ADEVs were measured. A correlation analysis was performed between neurotrophic factors in ADEVs and neurogenesis marker doublecortin (DCX) in neuron-derived extracellular vesicles (NDEVs). Subsequently, Mendelian randomization (MR) study and cell experiments were conducted.ResultsOur findings revealed a decrease in the level of epidermal growth factor (EGF) in ADEVs among TRD patients, with an increase observed post-ECT. The corrected area under the curve for EGF were larger than those for other neurotrophic factors: 0.99 (95% CI: 0.98-1.00). MR suggested that decreased expression levels of theEGFgene in the cortex constitute a risk factor for depression. We observed a positive correlation between the levels of EGF in ADEVs and DCX in NDEVs. Subsequently, cell experiments suggested that EGF can activate EGF receptor (EGFR) to trigger the PI3K-Akt pathway, participating in the promotion of DCX.ConclusionsThis study provides thein vivoevidences supporting that a reduction in EGF levels in the central nervous system could potentially contribute to depression and serve as a biomarker for it. Additionally, the EGF/EGFR signaling pathway may be involved in regulating early neurogenesis traits in depression.

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Section: Introductionmentioning

confidence: 99%