Distribution of Aqueous-Deficient and Evaporative Dry Eye in a Clinic-Based Patient Cohort

Abstract

The proportion of subjects exhibiting signs of evaporative dry eye resulting from MGD far outweighs that of subjects with pure ADDE in a general clinic-based patient cohort.

Diverse Mediators Modulate the Chloride Ion Fluxes That Drive Lacrimal Fluid Production

“…6 These estimates are 3-fold or more higher than estimates of the prevalence of dry eye disease. 7,8 The actual disparity between histopathology and physiologic dysfunction might be even more pronounced, given that recent work [9][10][11] suggests that dry eye disease most often begins when age-and hormonerelated changes in meibomian gland function 12 alter the thickness or composition of the lipid layer of the tear film 13 and that lacrimal fluid production subsequently decreases.…”

Additional Instruction by a Nurse Enhanced the Effect of Eyelid Warming on Subjective Symptoms in Patients with Meibomian Gland Dysfunction

“…A retrospective study found that 86% of patients with dry eye disease had meibomian gland dysfunction (MGD), indicating the importance of MGD in this disease [4]. MGD is characterized by obstruction of the orifices or impaired secretory function of meibomian glands, both of which give rise to dry eye symptoms such as a foreign body sensation, dryness and photophobia and it has a prevalence ranging from 46.2% to 61.9% in elderly individuals [5][6][7].…”

The Role of Omega-3 Essential Fatty Acids in Dry Eye Disease

“…In one large study, 86% of patients with dry eye disease had an evaporative component due to meibomian gland disease, (MGD) [7]. The Meibomian glands secrete meibum, the oil stabilizing the tear ilm, essential for a normal tear break up time and a moist cornea.…”