Distribution of Angiotensin-1 Converting Enzyme Insertion/Deletion and α-Actinin-3 Codon 577 Polymorphisms in Turkish Male Soccer Players

Ulucan, Korkut; Sercan, Canan; Bıyıklı, Türker

doi:10.4137/geg.s31479

Cited by 24 publications

(27 citation statements)

References 27 publications

(34 reference statements)

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“…Our study suggests that individuals with DD and ID genotypes are more predisposed to greater physical strength and power due to the presence of the D allele. Concordantly, our findings are in agreement with the studies made in Australia and Turkey (Ulucan et al, 2015;Jacob et al, 2018). In a Serbian study with female soccer players, there was a high prevalence of the DD genotype, suggesting that individuals with this genotype tend to perform better in soccer (Jeremic et al, 2019).…”

Section: Discussionsupporting

confidence: 92%

Research Article Assessment of effects of the genetic polymorphisms on soccer athletes

Menezes¹,

Gingozac²,

Oliveira³

et al. 2019

Genet. Mol. Res.

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Several genes have been identified as important in athletic performance. The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism has been related to improvements in performance and exercise duration. However, there are large divergences among studies on the influence of ACE I/D polymorphism on physical performance. Other studies have demonstrated that strenuous exercise generally overloads the endogenous antioxidant system's capacity, leading to oxidative damage to muscles and other tissues in athletes. Few studies have reported significant associations between glutathione S-transferase (GST) deletion polymorphisms and resistance performance in athletes. We examined the effects of ACE I/D and GST deletion polymorphisms in young soccer players in central Brazil. We included 65 soccer players from under-20 (18 to 20 years old) soccer ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 18 (2): gmr18192 W.C.F. Menezes et al. 2 teams and 60 non-athletes in a case-control study. All subjects had their physical performance investigated through the Running-based Anaerobic Sprint Test (RAST). Genotyping was performed using real-time PCR. We found that the I/D genotype was significantly more frequent in athletes compared with the non-athletes. Individuals with the ID and DD genotypes had an approximately 3.13-fold and 4.37-fold increase in strength and power-orientated performance, respectively. The DD genotype in athletes presented RAST-test results considered as excellent to good when compared with non-athletes. When we examined a possible association of the GST deletion polymorphisms and RAST test, we found no influence on athletic performance. We did find association between ACE I/D polymorphism and athletic performance. However, there was no association between GST polymorphisms and risk of oxidative damage in the muscles. Our findings may help to select young players with the most favorable genetic potential to succeed as soccer athletes.

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Section: Discussionsupporting

confidence: 92%

Research Article Assessment of effects of the genetic polymorphisms on soccer athletes

Menezes¹,

Gingozac²,

Oliveira³

et al. 2019

Genet. Mol. Res.

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“…Moreover, we showed that the distribution of the ACTN3 genotypes and alleles in the Iranian population is similar to those observed in several reported groups of Russian, Brazilian, and Turkish populations [10,24,26]. There were no statistically significant differences noted in the allelic frequencies between elite soccer players and control group participants, though sample size limitations prevented a conclusive analysis in this regard.…”

Section: Discussionmentioning

confidence: 67%

“…A study on Turkish male soccer players revealed that the frequencies of ACTN3 genotypes were 20, 36, and 44 for XX, RX, and RR, respectively, which agrees with the results of this study for each genotype [24]. In the Turkish study, an allelic frequency was found to be 31 (62%) and 19 (38%) for R and X alleles of ACTN3, respectively, which is similar to our findings (107 (59.4%) R and 73 (40.6%) X alleles).…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Relationship Between a Genetic Polymorphism in ACTN3 and Elite Sport Performance Among Iranian Soccer Players

Honarpour

Mohseni

Hajiagha

et al. 2017

IRJ

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Objectives: Polymorphisms in α-actinin-3 (ACTN3) gene are considered to be important in the genetic predisposition to human athletic performance. Most of the activities in soccer such as jumping, striking the ball, and running are considered plyometric and explosive. Performance power during such activities depends on the strength of the muscles involved. Therefore, high muscle strength is considered crucial for soccer players. The primary objective of this study was to ascertain the association between ACTN3 R577X (rs1815739) polymorphism and sports athletism in Iranian elite male soccer players. Methods:In total, 90 top-level professional Iranian male soccer players and 200 nonathletic Iranian men from the general population participated in this case-control study. Exon 16 of ACTN3 was genotyped throughout polymerase chain reaction (PCR) followed by Restriction Fragment Length Polymorphism (RFLP) using the restriction enzyme DdeI and direct sequencing. The genotypic and allelic frequencies of R577X polymorphism in athletes were compared to the frequencies in the general population (nonathletes).Results: According to the results, the percentage distributions of 577RR and 577RX genotypes (41% and 37%, respectively) were significantly higher and lower, respectively, than that of controls (25% and 57%, respectively) (P<0.001). However, no statistically significant difference was found between allelic frequencies (P=0.20).

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“…Since years, many of scientists study the role of Insertion/ Deletion polymorphism and their correlation between genetic and physiological backgrounds in sportspeople. Most research was concentrated on polymorphism in angiotensin converting enzyme (ACE) among athletes [32–36], swimmers [1,37,38], football players [39], volleyball players [24,40] or ball games players [41]. There is no research relating to ACE polymorphism among horse riders.…”

Section: Discussionmentioning

confidence: 99%

Genetic conditionality of strength by the ACE gene in women horse riders

Majchrowicz

Matłosz

2020

Preprint

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25The sport performance relies on hard work, intensity, duration of workout and 26 undoubtedly on genetic background. These components fold on multicausal character of 27 sport achievements. One of the best known genes associated with sport performance is 28 angiotensin converting enzyme gene (ACE). In this study, we showed ACE distribution 29 in women horse riders and the correlation between physiological and genetic 30 background, that should be taken into account when deciding to train sports discipline. 31 Data from 40 healthy female adults were collected. Participants trained horse-riding for 32 at least 3 years and participated in sport competition at least at national level and control 33 group consist of out of training persons. We analysed BMI, %FAT, cardiorespiratory 34 efficiency (VO2max), Complex Reaction Time, body balance, force and Lower Limbs 35 Explosive Force between both calculated groups. Physiological data was calculated by 36 non-parametric Mann-Whitney test with Dunnett`s post hoc test. The DNA 37 amplification from saliva was performed by PCR method to analyze the ACE genotype 38 distribution. In our study, for the first time we showed that the women training dressage 39 have higher force and complex reaction time than the control group. It was correlated 40 with possession of the D allele in genotype that is associated with muscle strength, 41 efficiency and muscle power. There is no research relating to ACE polymorphism 42 among horse riders. This paper showed angiotensin converting enzyme gene 43 distribution polymorphism in female Polish professional horse riders. This article 44 confirms correlation between genotype, sports results and physiological parameters.45 3 47 1. INTRODUCTION 48 Angiotensin converting enzyme (ACE) is well-known and one of the most 49 frequent under examined gene among sportsmen. An insertion/deletion (I/D) 50 polymorphism in the ACE gene occurrence is responsible for the control of blood 51 pressure in the body [1], as well as for predisposition to short-term or strength sports. 52 It's been long since known that sport success is the sum of genetic predisposition and 53 regular training. There is a lot of research of frequency of an insertion/deletion of 54 polymorphism among sportspeople training various olympic disciplines. Lack of 55 literature concerning I/D ACE polymorphism with horse-riders [1]. The aim of this 56 study was to show insertion/deletion of polymorphism in the ACE gene correlated with 57 horse-riders' physical condition and their professing sport discipline and enrich existing 58 literature about genetics of athletic performance. We also wanted to enrich the current 59 canon of knowledge about equestrianism.60Horse-riding is a highly demanding sport rank among olympic disciplines. It 61 split into 7 groups: dressage, show jumping, teaming, western riding, vaulting, long-62 distance rail and three-day event. Regardless of trained discipline, horse-riding demands 63 high physical condition, force and strength. Riding is most prestigious and...

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Distribution of Angiotensin-1 Converting Enzyme Insertion/Deletion and α-Actinin-3 Codon 577 Polymorphisms in Turkish Male Soccer Players

Cited by 24 publications

References 27 publications

Research Article Assessment of effects of the genetic polymorphisms on soccer athletes

Research Article Assessment of effects of the genetic polymorphisms on soccer athletes

Investigation of the Relationship Between a Genetic Polymorphism in ACTN3 and Elite Sport Performance Among Iranian Soccer Players

Genetic conditionality of strength by the ACE gene in women horse riders

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