Distribution of Alveolar Edema in Ventilated and Unventilated Canine Lung Lobes

Iancu, Daniel; Zwikler, M P; Michel, René P.

doi:10.1097/00004424-199607000-00005

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Does a Ct Image Of The Lung Contain Information About Alveol1

Pathology Of Ards: Importance Of Edema1

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Cited by 3 publications

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“…In this context, it has been suggested that the choice of injury model, PEEP, and tidal volume settings may determine the extent to which dependent alveolar edema is redistributed to more nondependent interstitial spaces (46).…”

Section: Does a Ct Image Of The Lung Contain Information About Alveolmentioning

confidence: 99%

Perspective on Lung Injury and Recruitment

Hubmayr

2002

Am J Respir Crit Care Med

277

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Section: Does a Ct Image Of The Lung Contain Information About Alveolmentioning

confidence: 99%

Perspective on Lung Injury and Recruitment

Hubmayr

2002

Am J Respir Crit Care Med

277

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“…Mechanical ventilation, with or without positive endexpiratory pressure (PEEP), appears to reduce alveolar edema and ameliorate gas exchange by at least two mechanisms, the first by opening and maintaining open the alveoli, and the second by redistributing the liquid from the alveolar spaces to the interstitium (31)(32)(33). Nevertheless, mechanical ventilation has significant disadvantages, particularly when large volumes of air are used; several studies have shown that the latter produces significant injury to pulmonary endothelial cells, with resulting permeability edema (34).…”

Section: Pathology Of Ards: Importance Of Edemamentioning

confidence: 99%

Acute Respiratory Distress Syndrome: 30 Years Later?

Lesur¹,

Berthiaume

Blaise

et al. 1999

Canadian Respiratory Journal

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Acute respiratory distress syndrome (ARDS) was first described about 30 years ago. Modern definitions and statements have recently been proposed to describe ARDS accurately, but none is perfect. Diffuse alveolar damage is the basic pathological pattern most commonly observed in ARDS, and the term includes permeability edema. The alveolar epithelium of the alveolar-capillary barrier is clearly a key component requiring repair, given its multipotent functional activity. Lung inflammation and neutrophil accumulation are essential markers of disease in ARDS, and a wide variety of pro- and anti-inflammatory cytokines have been described in the alveolar fluid and blood of patients. These molecules still have to prove their value as diagnostic or prognostic biomarkers of ARDS.Supportive therapy in ARDS improved in the past decade; mechanical ventilation with lung protective strategies and patient positioning are gaining interest, but the indications for corticosteroids for ARDS are still debated. Nitric oxide may have a place in the treatment of one-third of patients. Novel approaches, such as surfactant replacement and liquid ventilation, may further improve supportive therapy. Innovative interventions may be on the horizon in treatments that help to resolve or modulate common pathways of ARDS, such as inflammation (eg, granulocyte-colony stimulating factor) or epithelial repair (eg, keratinocyte growth factor).

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