Distribution of Adrenergic Receptor Subtypes in the Retractor Muscles of the Upper Eyelid

Esmaeli-Gutstein, Bita; Hewlett, Bryan R.; Pashby, Robert C.; Oestreicher, James H.; Harvey, Jack

doi:10.1097/00002341-199903000-00005

Cited by 34 publications

(15 citation statements)

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“…Its primary function is to assist in the retraction of both lids and is primarily innervated by alpha-2 adrenergic receptors although recent studies have also shown the presence of alpha-1 receptors [4]. This is of clinical significance in Horner's syndrome where the interruption of sympathetic supply to the muscle can result in ptosis and an elevation of the lower lid by as much as 1 mm [5].…”

Section: Discussionmentioning

confidence: 99%

Lower lid entropion secondary to treatment with alpha-1a receptor antagonist: a case report

Waqar

Simcock

2010

J Med Case Reports

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IntroductionThe use of alpha-1a receptor antagonists (tamsulosin) is widely accepted in the treatment of benign prostatic hypertrophy (BPH). It has previously been implicated as a causative agent in intra-operative floppy iris syndrome due to its effects on the smooth muscle. We report a case of lower lid entropion that may be related to a patient commencing treatment of tamsulosin.Case presentationA 74-year-old Caucasian man was started on alpha 1-a receptor antagonist (Tamsulosin) treatment for benign prostatic hypertrophy. Eight days later, he presented to the ophthalmology unit with a right lower lid entropion which was successfully treated surgically with a Weiss procedure.ConclusionWe report a case of lower lid entropion that may be secondary to the recent use of an alpha-1a blocker (tamsulosin). This can be explained by considering the effect of autonomic blockade on alpha-1 receptors in the Muller's muscle on a patient that may already have an anatomical predisposition to entropion formation due to a further reduction in muscle tone.

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Section: Discussionmentioning

confidence: 99%

Lower lid entropion secondary to treatment with alpha-1a receptor antagonist: a case report

Waqar

Simcock

2010

J Med Case Reports

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“…However, there is no difference in the adrenergic receptor distribution in Müller muscle of control subjects and patients with Graves upper eyelid retraction. 8 Therefore, it is unlikely that the Müller muscle of patients with Graves orbitopathy is supersensitive.…”

Section: Discussionmentioning

confidence: 99%

Effect of Darkness on Upper Eyelid Position

Neves

Cruz²

2005

Ophthalmic Plastic & Reconstructive Surgery

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“…Such fibro-fatty degeneration of Müller's muscle was recently observed on direct visualization on phenylephrine negative patients undergoing open sky MMCR [47] . Further, histopathological studies demonstrating a high concentration of alpha-2 receptors in Müller's muscle suggest that its response to phenylephrine may not represent its full role in eyelid retraction [66] .…”

Section: Müller's Muscle Revisitedmentioning

confidence: 99%

Ptosis repair: external levator advancement vs. Muüller’s muscle-conjunctiva resection - techniques and modifications

Laplant¹,

Kang²,

Cockerham³

2020

Plast Aesthet Res

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Surgical techniques for ptosis repair continue to evolve as we gain a better understanding of the anatomy and physiology of the eyelid. External repair by levator advancement and internal repair by Müller's muscleconjunctiva resection are the most established surgical techniques used for acquired ptosis today. Controversy over their relative indications, advantages, and disadvantages exist. The advent of new surgical techniques and modifications has further complicated traditional algorithms that guide a surgeon towards choosing an external vs. internal approach. Specifically, the use and interpretation of pre-operative phenylephrine testing has recently been challenged. The purpose of this study is to review the evolution of external and internal ptosis repair techniques, and current trends in pre-operative evaluation and surgical management of acquired ptosis.

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Distribution of Adrenergic Receptor Subtypes in the Retractor Muscles of the Upper Eyelid

Cited by 34 publications

References 0 publications

Lower lid entropion secondary to treatment with alpha-1a receptor antagonist: a case report

Lower lid entropion secondary to treatment with alpha-1a receptor antagonist: a case report

Effect of Darkness on Upper Eyelid Position

Ptosis repair: external levator advancement vs. Muüller’s muscle-conjunctiva resection - techniques and modifications

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