Distribution of actin and myosin in muscle and non-muscle cells

Toh, Ban‐Hock; Yıldız, Akın; Sotelo, Julio; Osung, O.; Holborow, E. J.; Fairfax, A J

doi:10.1007/bf00237731

Cited by 24 publications

(14 citation statements)

References 13 publications

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“…Splenic white pulp also showed heavy labeling by using SMA (16). In our study the germinal center was not stained by DACM-HMM and the difference might be due to the germinal center between lymph node and spleen.…”

Section: Discussioncontrasting

confidence: 54%

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Actin localization in various rat tissues stained with DACM labeled heavy meromyosin.

Usui

Miyazaki

Kuroda

et al. 1985

Acta Histochem. Cytochem

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Section: Discussioncontrasting

confidence: 54%

“…However, the specificity of SMA bound to actin is different from the anti-actin antibody raised against prepared actin (2,4,16). In several observations SMA was suggested to contain antibodies reacted with intermediate filaments (13,15).…”

Section: Discussionmentioning

confidence: 98%

Actin localization in various rat tissues stained with DACM labeled heavy meromyosin.

Usui

Miyazaki

Kuroda

et al. 1985

Acta Histochem. Cytochem

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“…The pathogenetic potential of such shared antigenic epitopes has long been recognized in rheumatic fever (35,36) and more recently in Chagas' disease (37), myasthenia gravis (38), and celiac sprue (39). Another possible example of molecular mimicry is the antigenic cross-reactivity of intermediate filaments of the vimentin-type and viral proteins from herpes simplex or measles virus (40)(41)(42). Although the cytoplasmic staining ofsynovial lining cells in situ and in vitro was suggestive of reaction with intermediary filaments such as vimentin, several lines ofevidence argue against this possibility.…”

Section: Methodsmentioning

confidence: 99%

Rheumatoid arthritis synovial membrane contains a 62,000-molecular-weight protein that shares an antigenic epitope with the Epstein-Barr virus-encoded associated nuclear antigen.

Fox¹,

Sportsman²,

Rhodes³

et al. 1986

J. Clin. Invest.

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“…(i) Autoantibodies have been detected in patients with viral infections, including patients infected with EBV (18,19), mumps or measles virus (20,21), chickenpox virus (22), and human immunodeficiency virus (23). (ii) Chronic infection of goats with caprine arthritis-encephalitis virus is associated with rheumatoid arthritis-like joint lesions (24).…”

Section: Discussionmentioning

confidence: 99%

Two short autoepitopes on the nuclear dot antigen are similar to epitopes encoded by the Epstein-Barr virus.

Xie

Snyder

1995

Proc. Natl. Acad. Sci. U.S.A.

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To understand the relationship between antibodies present in patients with anti-nuclear dot (ND) autoimmune disease and the proteins they recognize, epitopes that react with the autoantibodies were mapped. A panel of fusion proteins containing different portions of the ND protein were overproduced in Escherichia coli. Immunoblot analysis with anti-ND antibodies revealed that most (10 of 12) sera recognize two major autoepitopes that are each a maximum of 8 amino acids long. The other two sera recognize one of the two epitopes. In addition to the short linear autoepitopes, a conformational epitope appears to be present on the ND antigen. Each of the two linear epitope sequences shares sequence similarities with those of several viral proteins found in the databases. Furthermore, two fusion proteins containing short Epstein-Barr virus (EBV) protein sequences that are similar to the ND epitopes were recognized by the human autoimmune sera, indicating that the autoepitopes are present in EBV protein sequences. Our results are consistent with the hypothesis that ND autoimmune disease might be associated with EBV infections. Anti-nuclear antibodies are found in a variety of different autoimmune disease patients. In many cases, the reactivity of the antibody produced often correlates with the particular disease (e.g., ref. 1). Despite this fact, the etiology of both the disease and antibodies is unknown. Furthermore, since many autoantigens reside in the nucleus and are, therefore, presumably inaccessible to autoantibodies, it is also unclear to what extent the antibodies contribute to the pathogenesis, especially in the initial stages of the autoimmune disease.Several models have been proposed to account for the etiology and pathogenesis of autoimmune disease. One of these, the molecular mimicry model (2), states that an infecting agent such as a bacteria or virus might be involved in the onset or pathology of the disease. Antibodies produced against the infecting agent might cross-react with cellular antigens and, potentially, contribute to the disease state.Recently, efforts have been directed toward mapping epitopes recognized by antibodies isolated from patients with different types of autoimmune diseases. Thus far, epitopes have been mapped for a variety of different autoantigens, and some of these are similar to viral sequences (3-6). For example, autoepitopes have been mapped on the a subunit of the acetylcholine receptor that is associated with myasthenia gravis (3) and on the diffuse systemic sclerosis antigen DNA topoisomerase I (4). The a subunit of acetylcholine receptor exhibits immunological cross-reactivity with a homologous domain on herpes simplex virus glycoprotein D (3), while the antigenic 11-amino acid region of DNA topoisomerase I contains a 6-amino acid sequence that is identical to a sequence present in the group-specific antigen (p309ag) of some mammalian retroviruses (4). However, the usefulness of these studies is limited because in most instances mapping was doneThe publication cost...

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Distribution of actin and myosin in muscle and non-muscle cells

Cited by 24 publications

References 13 publications

Actin localization in various rat tissues stained with DACM labeled heavy meromyosin.

Actin localization in various rat tissues stained with DACM labeled heavy meromyosin.

Rheumatoid arthritis synovial membrane contains a 62,000-molecular-weight protein that shares an antigenic epitope with the Epstein-Barr virus-encoded associated nuclear antigen.

Two short autoepitopes on the nuclear dot antigen are similar to epitopes encoded by the Epstein-Barr virus.

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