Distribution of Aconitum alkaloids in autopsy cases of aconite poisoning

L-Type Calcium Channel Inhibition Contributes to the Proarrhythmic Effects of Aconitine in Human Cardiomyocytes

“…The current study adopted concentrations of ACO ranged from 0.03 to 3 μM which is consistent with that (0.1 ~10 μM) adopted in the previous in vitro studies [7~10] and it covered the blood concentrations (0.02 ~ 0.11 μM) identified in patients with ACO-induced lethal cardiac arrhythmia [27]. …”

Case reports of aconite poisoning in mainland China from 2004 to 2015: A retrospective analysis

“…The concentration of Aconitum alkaloids was reported to be high in the liver and kidney, but low in the heart and cerebrum of poisoned individuals. [39]. However, in the reports analyzed here, urine test results were included in only 3 cases.…”

Identification and Quantification of Aconitines and Colchicine in Serum, Urine, and Plants using MonoSpin C18 and LC-MSMS

“…Life-threatening arrhythmia, ventricular tachycardia, and ventricular fibrillation, and eventually death, occur as a result of respiratory paralysis or cardiac arrest. The lethal dose of aconitine alkaloids for humans is estimated to be 1-2 mg. Several cases of accidental or suicidal ingestion of aconitum have been reported in Japan and other countries [1,2]. Although homicidal death is extremely rare, homicidal poisoning cases have been reported [3][4][5].…”

“…Recovery of all compounds from urine, spiked at concentrations of 0. 1,8,80 and 190 ng mL −1 , ranged from 96.6 to 101.9 %. The intraand inter-assay accuracy and precision (expressed as relative standard deviation, %RSD) evaluated for all compounds were within 96.7-103.2 % and 1.7-11.5 %, respectively.…”