Distribution of Abo Blood Groups in Childhood Acute Leukemia

Abstract

The distribution of ABO blood groups was determined in a multicenter study of 682 pediatric patients with acute lymphoblastic leukemia (ALL) and 224 patients with acute myeloid leukemia (AML) up to 12 years old. The overall distribution of blood groups was significantly different in both ALL and AML groups from the control group (p < .001). In the ALL group there were 56.5% (95% CI: 45.8-67.1) more patients with O blood group, 35.8% (95% CI: 27.0-44.5) fewer patients with A blood group, and 26.9% (95% CI: 12.7-39.2) fewer patients with B blood group. In the AML group, there were 28.8% (95% CI: 10.8-46.9) more patients with A blood group. The results indicate that alteration in ABO antigens might be associated with an increased risk of ALL.

Clinical characteristics of acute lymphoblastic leukemia in male and female patients: A retrospective analysis of 705 patients

“…Jackson et al (34) found that the proportion of Malay male patients with the O blood group was significantly higher compared with the proportion of female patients, which was considered to explain the increased incidence of acute leukemia in males. Similar to the present outcomes, Alavi et al (35) reported that the most frequent blood type of paediatric patients with ALL in Iran was the O blood group, overall (56.5%) and in male (56.7%) and female (54.4%) patients. There was also no statistical difference in blood type distribution between the genders.…”

Relationships between Skin Cancers and Blood Groups - Link between Non-melanomas and ABO/Rh Factors

“…Several studies also demonstrated that the incidence of laryngeal and hypopharyngeal cancer, acute myeloid leukemia, ovarian, pancreatic, breast, vulvar and gastric cancer was higher in individuals with A blood group (Henderson et al, 1993;Su et al, 2001;Rolfe et al, 2002;Vadivelu et al, 2004;El Hajj et al, 2007;Edgren et al, 2010;Greer et al, 2010). There are also various studies indicating that the incidence of esophageal squamous cell carcinoma, gastric cancer, acute lymphoblastic leukemia and malignant melanoma was higher in individuals with 0 blood group, while the incidence of endometrial cancer and advanced esophageal cancer was higher in individuals with AB blood group and the incidence of pancreatic cancer, Hodgkin's lymphoma and cardial cancer was higher in individuals with B blood group (Karakousis 1986;Su et al, 2001;Alavi et al, 2006;El Hajj et al, 2007;Vincenzo et al, 2011). So far, no relationship has been observed between the ABO blood groups in patients with brain cancer, cervical cancer, salivary gland cancer, testicular cancer and skin cancer, and the blood subtypes in healthy individuals (Mittal, 1970;Jordon et al, 1989;Pinkston and Cole, 1996;Mehrazin, 2006).…”

Prognostic Factors and Survival in Acute Myeloid Leukemia Cases: a Report from the Northeast of Iran

“…Overally, M7 and M6 have lower frequency and M4 and M2 have higher frequency. In AML patients in a research (Vadivelu et al, 2004), there were 14.3% patients with O blood group and in other research (Alavi et al, 2006), 28.8% patients were with A blood group. In this study, O blood group (32.6%) and A blood group (32.5%) had the highest prevalence.…”