Distribution of 58 Semi-Volatile Organic Chemicals in the Gas Phase and Three Particle Sizes in Indoor Air and House Dust in Residential Buildings During the Hot Season in Japan

Takeuchi, Shinji; Tanaka-Kagawa, Toshiko; Saito, Ikue; Kojima, Hiroyuki; Jinno, Hideto

doi:10.1248/bpbreports.2.6_91

Cited by 5 publications

(4 citation statements)

References 43 publications

(51 reference statements)

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“…In contrast, the indoor average concentration of Case 2 and Case 3 was similar to that was found in previous studies [36][37][38][39] and did not exceed the surface concentration calculated saturated vapour pressure under 25°C.…”

Section: Prediction Accuracy Of Diethyl-hexyl Phthalate Exposure Anal...supporting

confidence: 88%

“…Saito, Onuki and Seto 38 assessed a house in Tokyo and found the maximum to be 2.4 μg/m 3 , and the minimum to be 0.052 μg/m 3 . Additionally, Takeuchi et al 39 reported a maximum value of 1.3 μg/m 3 and a median value of 0.60 μg/m 3 for a house in Japan. Hence, the indoor average concentration of Case 1-1 was overestimated by approximately 18 times the highest value as was reported by Saito et al 38 In Case 1-1, the upper limit of the exposure concentration was shown by integrating the MFA and indoor CFD analysis assuming the worst-case environment.…”

Section: Discussionmentioning

confidence: 99%

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Multiscale analysis of material flow and computational fluid dynamics for predicting individual diethyl-hexyl phthalate exposure concentration in indoors

Muta

Yoo

Kim

et al. 2022

Indoor and Built Environment

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The establishment of a healthy indoor environment requires the accurate evaluation of an individual’s exposure to pollutants. The concentration of indoor chemical pollutants is a representative indicator for such evaluation and is generally measured on-site. Moreover, material flow analysis (MFA), using macroscopic statistical data, is a reasonable method for objectively evaluating pollution on a wide scale; however, no effective strategy exists for the prediction of indoor air pollution, nor for the assessment of an individual’s exposure from social stock data. Accordingly, we developed a novel integration method comprising MFA and computational fluid dynamics (CFD) with a computer-simulated person (CSP) to establish a framework for evaluating indoor pollutant concentration and individual exposure of residents. We focused on diethyl-hexyl phthalate (DEHP) and first estimated the amount of DEHP-containing product accumulation in Japan by MFA. Second, we conducted a thorough survey and measurement of DEHP emission rates. Using these results as boundary conditions for indoor CFD with CSP, the individual exposure of a resident, in a standard residential house, was quantitatively evaluated. The total daily exposure per unit of body weight was estimated to be more than 100 (μg/kg/d) in the worst-case scenario which was considered the upper limit for exposure in this analysis.

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Section: Prediction Accuracy Of Diethyl-hexyl Phthalate Exposure Anal...supporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Multiscale analysis of material flow and computational fluid dynamics for predicting individual diethyl-hexyl phthalate exposure concentration in indoors

Muta

Yoo

Kim

et al. 2022

Indoor and Built Environment

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“…From 1997 through 2002, the Ministry of Health, Labour, and Welfare (MHLW) in Japan established indoor air guidelines to maintain public health for 13 VOCs and semi-volatile organic compounds, including aldehydes, alkanes, aromatic hydrocarbons, pesticides, and phthalates (MHLW, 2000a(MHLW, , 2000b(MHLW, , 2001(MHLW, , 2002. In a recent nationwide sur-Correspondence: Hideto Jinno (E-mail: jinno@meijo-u.ac.jp) vey of indoor air pollutants in Japan ( Takeuchi et al, 2020 ), three resin additive-related compounds were found at high concentrations and/or high frequency, including 2-ethyl-1-hexanol (2-EH), 2,2,4-trimethyl-1,3-pentanediol 1-and 3-monoisobutyrate (Texanol), and 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TXIB), which were selected as candidate compounds to establish indoor air guidelines ( MHLW, 2017 ) ( Fig. 1 ).…”

Section: Introductionmentioning

confidence: 99%

Species differences in activation of TRPA1 by resin additive-related chemicals relevant to indoor air quality

et al. 2023

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Transient Receptor Potential Ankyrin 1 (TRPA1), which is expressed in the airways, has causative and exacerbating roles in respiratory diseases. TRPA1 is known as a target of sick building syndrome-related air pollutants, such as formaldehyde. Thus, an in vitro TRPA1 activation assay would be useful for predicting the potential risk of air pollution. In this study, we used human TRPA1 (hTRPA1)and mouse TRPA1 (mTRPA1)-expressing cell lines to measure TRPA1 activation by the emerging indoor air pollutants 2-ethyl-1-hexanol (2-EH), a mixture of 2,2,4-trimethyl-1,3-pentanediol 1-and 3-monoisobutyrate (Texanol), and 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TXIB). The results indicated that 2-EH activated both hTRPA1 and mTRPA1 in a concentration-dependent manner, whereas TXIB did not activate hTRPA1 or mTRPA1. Texanol also activated hTRPA1 in a concentration-dependent manner. In contrast, a bell-shaped concentration-dependent curve was observed for mouse TRPA1 activation by Texanol, indicating inhibitory effects at a higher concentration range, which was also reported for menthol, a typical TRPA1 modulator. To further elucidate the mechanism underlying the species difference in TRPA1 activation by Texanol, V875G and G878V mutations were introduced into hTRPA1 and mTRPA1, respectively, which were reported to be key mutations for the inhibitory effect of menthol. These mutations switched the inhibitory effects of Texanol; thus, hTRPA1/V875G, but not mTRPA1/ G878V, was inhibited at higher concentrations of Texanol. These results indicate that Texanol shares an interaction site with menthol. Overall, these findings suggest that careful interpretation is necessary when extrapolating rodent TRPA1-dependent toxicological effects to humans, especially with respect to the risk assessment of indoor air pollutants.

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“…VOCs and SVOCs other than those indicated by the current indoor concentration guideline values have been detected in the indoor air of Japanese residential houses 2,3) . Spray products such as air fresheners and deodorizers that are sprayed on fabrics and indoor air include aerosol and hand-pump type products, which have gener-ated concern as one of the sources of VOCs and SVOCs.…”

Section: Introductionmentioning

confidence: 99%

Survey of Phthalates, Glycols, and Other Volatile Organic Compounds in Domestic Hand-pump Spray Products and Evaluation of Their Effect on Indoor Air Quality

et al. 2022

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Summar yThe Committee on Sick House Syndrome: Indoor Air Pollution (Ministr y of Health, Labour and Welfare, Japan) recommended reviewing guideline values for harmful compounds for the purpose of risk evaluation. In this study we selected domestic hand-pump spray products and focused on compounds listed as candidates for revision of guideline values and as new additions to the guideline value list. We also examined appropriate analytical methods, surveyed the product states; and after using specific products, calculated the average indoor concentrations of the detected compounds and considered their effect on indoor air quality.A total of 33 compounds [9 phthalates, 20 glycols, and 4 volatile organic compounds (VOCs)] were analyzed in 33 products. Four phthalates (0.47 to 9.8 mg/L) were detected in six products, fifteen glycols (0.46 to 3,200 mg/L) in thirty-two products, and two VOCs (0.51 to 10 mg/L) in eight products, respectively. Estimation of the average concentrations of the detected compounds in indoor air after product use showed that phthalates and VOCs were within the recommended threshold values for indoor air, indicating that those products had a low probability of being a source of indoor air pollution. However, comparatively high concentrations of glycols, diethylene glycol monomethyl ether, and diethylene glycol monoethyl ether were measured, suggesting that the use of products containing these ingredients could markedly affect indoor air quality. The findings showed that domestic hand-pump spray products may act as a significant source of glycol emissions.

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Distribution of 58 Semi-Volatile Organic Chemicals in the Gas Phase and Three Particle Sizes in Indoor Air and House Dust in Residential Buildings During the Hot Season in Japan

Cited by 5 publications

References 43 publications

Multiscale analysis of material flow and computational fluid dynamics for predicting individual diethyl-hexyl phthalate exposure concentration in indoors

Multiscale analysis of material flow and computational fluid dynamics for predicting individual diethyl-hexyl phthalate exposure concentration in indoors

Species differences in activation of TRPA1 by resin additive-related chemicals relevant to indoor air quality

Survey of Phthalates, Glycols, and Other Volatile Organic Compounds in Domestic Hand-pump Spray Products and Evaluation of Their Effect on Indoor Air Quality

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