Distribution of 5‐ht<sub>1E</sub> receptors in the mammalian brain and cerebral vasculature: an immunohistochemical and pharmacological study

Klein, MT; Teitler, Milt

doi:10.1111/j.1476-5381.2012.01868.x

Cited by 24 publications

(24 citation statements)

References 41 publications

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“…Pinealocytes also stain immunohistochemically for NSE (Neuron specific enolase), and the main neurotransmitter is serotonin. The interstitial cells, the astrocytes and oligodendrocytes stain with GFAP (Glial fibrillary acidic protein), S-100, vimentin and antigen C1, its main neurotransmitter also being serotonin [16,56–58].…”

Section: Resultsmentioning

confidence: 99%

The morphological and functional characteristics of the pineal gland

Gheban

Rosca

Crışan

2019

Medicine and Pharmacy Reports

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Introduction. The pineal gland is a photo-neuro-endocrine organ situated inside the brain, that secretes serotonin, melatonin and N,N-dymethyltriptamine. This narrative review will address the latest information gathered on this function of the gland as well as the unknown roles it may have. The different histological and pathological findings of the pineal gland have demonstrated a role in clinical manifestations of numerous endocrine, neurological and psychiatric pathologies. Materials. For this narrative review we used the NCBI website database PubMed. The search terms were “Pineal Gland” AND/OR “histology, melatonin, DMT, pathology”. Total number of articles included were 86. Results: We have reviewed physiological information of melatonin and DMT, anatomical, histological and histopathological information on the pineal gland and its role in endocrine, neurological and psychiatric pathology. Conclusion. The role of melatonin in immunity and its potential therapeutic effects show promising potential for further research. DMT seems to have a role in psychiatric pathology and potential therapeutic effects. Proper tumoral screening and diagnostic protocol are required.

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Section: Resultsmentioning

confidence: 99%

The morphological and functional characteristics of the pineal gland

Gheban

Rosca

Crışan

2019

Medicine and Pharmacy Reports

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“…High levels in olfactory bulb glomeruli and molecular layer of dentate gyrus. Low amounts in the adventitial layer of cerebral arteries (Klein and Teitler, 2012) Inhibition of adenylyl cyclase 5-HT (Barnes and Sharp, 1999), psilocybin (McKenna et al, 1990) None (methiothepin weak) ( Barnes and Sharp, 1999) N/A 5-HT 2A receptor occupancy produced by the psilocybin metabolite psilocin in humans. That was done by the Copenhagen group led by Knudsen who used the PET tracer [ 11 C]Cimbi-36.…”

Section: Gimentioning

confidence: 99%

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research

et al. 2019

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Background: In the past few years, the issue of ‘microdosing’ psychedelics has been openly discussed in the public arena where claims have been made about their positive effect on mood state and cognitive processes such as concentration. However, there are very few scientific studies that have specifically addressed this issue, and there is no agreed scientific consensus on what microdosing is. Aim: This critique paper is designed to address questions that need to be answered by future scientific studies and to offer guidelines for these studies. Approach: Owing to its proximity for a possible approval in clinical use and short-lasting pharmacokinetics, our focus is predominantly on psilocybin. Psilocybin is allegedly, next to lysergic acid diethylamide (LSD), one of the two most frequently used psychedelics to microdose. Where relevant and available, data for other psychedelic drugs are also mentioned. Conclusion: It is concluded that while most anecdotal reports focus on the positive experiences with microdosing, future research should also focus on potential risks of (multiple) administrations of a psychedelic in low doses. To that end, (pre)clinical studies including biological (e.g. heart rate, receptor turnover and occupancy) as well as cognitive (e.g. memory, attention) parameters have to be conducted and will shed light on the potential negative consequences microdosing could have.

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“…Further functional investigation may reveal this to be the mechanism behind expression changes, which could potentially be used clinically as early indicators of vasospasm leading to DCI. The serotonin receptor 1E is also present in cerebral arteries 26 although little is known about its precise functionality. Variations in the serotonin receptor 2A and serotonin receptor 2C are known targets for SSRIs, 27 which have been shown to improve functional outcomes when given post-stroke.…”

Section: Discussionmentioning

confidence: 99%

A pilot study on the impact of dopamine, serotonin, and brain-derived neurotrophic factor genotype on long-term functional outcomes after subarachnoid hemorrhage

et al. 2017

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Objectives:Many that survive an aneurysmal subarachnoid hemorrhage experience lasting physical disability, which might be improved by medications with effects on the dopaminergic, serotonergic, and brain-derived neurotrophic factor neurotransmitter systems. But it is not clear which patients are most likely to benefit from these therapies. The purpose of this pilot study was to explore the relationship of genetic polymorphisms in these pathways with 12-month functional outcomes after aneurysmal subarachnoid hemorrhage.Methods:Subjects were recruited at the time of admission as a part of a larger parent study. Genotypes were generated using the Affymetrix genome-wide human single-nucleotide polymorphism array 6.0. Those within dopaminergic, serotonergic, and brain-derived neurotrophic factor pathways were analyzed for associations with functional outcomes at 12 months post aneurysmal subarachnoid hemorrhage using the Glasgow Outcome Scale and the Modified Rankin Scale.Results:The 154 subjects were 55.8 ± 11.3 years old and 74% female; they had Fisher scores of 2.95 ± 0.67, Hunt/Hess scores of 2.66 ± 1.13, and admission Glasgow Coma Scale scores of 12.52 ± 3.79. Single-nucleotide polymorphisms in the serotonin receptor genes 1B and 1E and dopamine receptor D2 were associated with greater disability (odds ratio: 3.88–3.25, confidence interval: 1.01–14.77), while single-nucleotide polymorphisms in the serotonin receptor genes 2A and 2C and dopamine receptor D5 conferred a risk of poor recovery (odds ratio: 3.31–2.32, confidence interval: 1.00–10.80). Single-nucleotide polymorphisms within the same serotonin genes, and within the dopamine receptor gene D2, were associated with greater recovery after aneurysmal subarachnoid hemorrhage (odds ratio: 0.17–0.34, confidence interval: 0.05–0.89).Conclusions:These data demonstrate that there may be an association between genetic factors and functional outcomes post stroke.

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Distribution of 5‐ht_1E receptors in the mammalian brain and cerebral vasculature: an immunohistochemical and pharmacological study

Cited by 24 publications

References 41 publications

The morphological and functional characteristics of the pineal gland

The morphological and functional characteristics of the pineal gland

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research

A pilot study on the impact of dopamine, serotonin, and brain-derived neurotrophic factor genotype on long-term functional outcomes after subarachnoid hemorrhage

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Distribution of 5‐ht1E receptors in the mammalian brain and cerebral vasculature: an immunohistochemical and pharmacological study

Cited by 24 publications

References 41 publications

The morphological and functional characteristics of the pineal gland

The morphological and functional characteristics of the pineal gland

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research

A pilot study on the impact of dopamine, serotonin, and brain-derived neurotrophic factor genotype on long-term functional outcomes after subarachnoid hemorrhage

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Distribution of 5‐ht_1E receptors in the mammalian brain and cerebral vasculature: an immunohistochemical and pharmacological study