Distribution of 3H-methylatropine in rat brain

Witter, A.; Slangen, Jef L.; Terpstra, G.K.

doi:10.1016/0028-3908(73)90036-1

Cited by 30 publications

(10 citation statements)

References 6 publications

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“…Instead, the effect of methylatropine is likely to be due to penetration into the CNS. After equivalent doses of radioactive atropine or methylatropine, both drugs accumulate in the CNS (58). Systemic methylatropine has effects on cortical activity that are dependent on the dose and treatment duration, with 1 mg/kg (i.v.)…”

Section: 6mentioning

confidence: 99%

Severe peri-ictal respiratory dysfunction is common in Dravet syndrome

Kim¹,

Bravo²,

Thirnbeck³

et al. 2018

Journal of Clinical Investigation

117

168

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Section: 6mentioning

confidence: 99%

Severe peri-ictal respiratory dysfunction is common in Dravet syndrome

Kim¹,

Bravo²,

Thirnbeck³

et al. 2018

Journal of Clinical Investigation

117

168

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“…Dose-effect data on the behavioral effects of oxotremorine, neostigmine, oxotremorine-M, or bethanechol are not avai!able in squirrel monkeys. The relative abilities of atropine sulfate or the quaternary antimuscarinic atropine methylnitrate (Herz et al 1965 ;Witter et al 1973) to alter the behavioral effects of the cholinesterase inhibitors or the muscarinic agonists was determined. By studying both quaternary and tertiary agonists against both quaternary and tertiary antagonists, it was possible to make refined conclusions regarding relative involvements of CNS and PNS receptor populations.…”

mentioning

confidence: 99%

Central and peripheral muscarinic actions of physostigmine and oxotremorine on avoidance responding of squirrel monkeys

Witkin

1989

Psychopharmacology

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The involvement of central and peripheral muscarinic cholinergic receptors in the behavioral effects of the cholinesterase inhibitor physostigmine was evaluated by comparing the ability of atropine and methylatropine to reverse the effects of physostigmine, the muscarinic agonist oxotremorine, or their quaternary analogs neostigmine and oxotremorine-M. Avoidance behavior was maintained under a schedule in which every lever press postponed delivery of electric shock for 20 s; shock occurred every 5 s in the absence of responding. Cumulative doses of physostigmine or oxotremorine produced dose-related decreases in response rates, and increases in response durations and rates of shock delivery. Similar effects occurred with neostigmine and oxotremorine-M. Methylatropine completely prevented the behavioral and parasympathetic effects of neostigmine and oxotremorine-M without having any behavioral effects of its own. However, methylatropine did not alter the behavioral effects of physostigmine or oxotremorine. Atropine prevented the peripheral manifestations as well as the behavioral effects of physostigmine and oxotremorine even though atropine decreased avoidance responding when given alone. These results suggest that in squirrel monkeys, central and peripheral muscarinic receptors may function in a redundant manner to control agonist-induced decrements in avoidance. When physostigmine or oxotremorine was given in conjunction with atropine, rates of avoidance responding were increased to 180% of control levels. Response rate increases after administration of oxotremorine or physostigmine in monkeys treated with atropine may reflect a non-muscarinic action of atropine, unmasked by the presence of cholinomimetics.

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“…Similarly, systemic injections of agonists will stimulate activity indiscriminately at all muscarinic synapses. Peripheral drug actions may be controlled for using quaternary analogs, which cross the bloodbrain barrier very poorly (although under some conditions they may achieve CNS concentrations sufficient to affect behavior) (Albanus et at., 1968a,b;Witter et at., 1973). Second, effects of systemic injections of centrally acting drugs represent a net effect on the entire CNS.…”

Section: Methodological Issuesmentioning

confidence: 99%