Distribution of 31 endocrine-disrupting compounds in the Taihu Lake and application of the fish plasma model

Abstract

Background: The successful application of Fish plasma model (FPM) will greatly simplify the risk assessment of drugs. At present, the FPM has been applied to the risk assessment of several human drugs with high hydrophobicity. However, its applicability to a wide variety of compounds needs to be tested. Field work about distribution characteristics of endocrine disrupting compounds (EDCs) in water and in fish plasma plays a key role in promoting the successful application of FPM. However, there are few reports on the distribution of EDCs in fish, especially in wild fish plasma. Results: The distribution of 31 EDCs, including seven estrogens, eight androgens, six progesterones, five glucocorticoids, and five industrial compounds, in water and plasma of five categories of wild fishes in Taihu Lake was studied and the typical FPM was tested by the field data. The detected concentration of most compounds is relatively low (< 10 ng/L), and the industrial compounds are the predominant pollutants with the highest concentration up to 291.7 ng/L (Bisphenol A) in water. In general, glucocorticoids were detected at the highest concentrations in plasma of all kinds of fishes, followed by industrial compounds and estrogens. Except for glucocorticoids (up to 43.61 for Cortisone), the average concentrations of the other four categories of EDCs in fish plasma were generally low (< 10 μg/L). The available measured bioaccumulation factors (BAFs) of 20 kinds of EDCs were in the range of 0 to 5626. The bioaccumulation of EDCs in fish plasma is not only hydrophobicity-dependent, but is also both fish species-specific and compound-dependent. The classical FPM was tested and the results indicated that the good coincides of measured log BAFs and the theoretical log BCFs were only observed for limited EDCs (7 out of 20). The present available FPM generally underestimated the Log BAFs of most hydrophilic EDCs (log Kow < 3.87, 11 out of 20) whereas overestimated the Log BAFs of several high hydrophobic EDCs (Log Kow > 3.87) in fish plasma. Conclusion: Although the present FPM is barely satisfactory, it is still promising for predicting the accumulation of EDCs in fish plasma and for further environmental risk assessment.

Factors Determining the Susceptibility of Fish to Effects of Human Pharmaceuticals

“…Only a handful of studies have investigated the distribution of pharmaceuticals within the bodies of exposed wild fish , where drug accumulation is compound- and species-specific. , Instead, the majority of distribution data available for pharmaceuticals in fish are from time-course laboratory bioconcentration studies. In one such study, atenolol and venlafaxine displayed tissue-specific distribution in zebrafish, with bioaccumulation directly correlating with the lipid content of each tissue .…”

Effects of carbamazepine on the central nervous system of zebrafish at human therapeutic plasma levels

“…In short, the reliability of FPC prediction by the FPM for polar drugs and certain fish species needs further verification. Our previous work 16 on 31 polar endocrine disrupting compounds (EDCs) in the plasma of wild fish from Lake Taihu showed that the bioaccumulation of EDCs in fish plasma is not only dependent on hydrophobicity but also fish species-specific and compound-dependent. The classic FPM was appropriate for only a few EDCs (7 of 20), and the FPM underestimated the log BAFs (bioaccumulation factors) of the most less hydrophobic EDCs (log Kow : 1.5–3.5, 11 out of 20) while overestimating the log BAFs of several relatively higher hydrophobic EDCs (log Kow : 3.87–5.9) in fish plasma.…”