Distribution Frequency of Pathogenic Bacteria Isolated from Cutaneus Leishmaniasis Lesions

Ziaei, Hengameh; Sadeghian, G; Hejazi, Seyed Hossein

doi:10.3347/kjp.2008.46.3.191

Cited by 21 publications

(14 citation statements)

References 5 publications

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“…Staphylococcus aureus was the most prevalent organism in these lesions. [1011] This study showed decreased activity of glucantime in lesions of CL infected with secondary bacterial infection with the prevalence of 23.6%. The most prevalent-isolated organism was Staphylococcus aureus confirming the results of previous studies.…”

Section: Discussionmentioning

confidence: 84%

Decreased effect of glucantime in cutaneous leishmaniasis complicated with secondary bacterial infection

et al. 2011

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Background:Glucantime is regarded as the first-line treatment of cutaneous leishmaniasis (CL); however, failure to treatment is a problem in many cases.Aim:The aim was to evaluate the therapeutic effect of glucantime in CL complicated with secondary bacterial infection compared to uncomplicated lesions.Methods:This experimental study was performed in Skin Diseases and Leishmaniasis Research Center, Isfahan, Iran. A total of 161 patients enrolled in the study had CL confirmed by positive smear of lesions. All the patients were treated with systemic glucantime for 3 weeks and followed for 2 months. Response to treatment was defined as loss of infiltration, reepithelization, and negative smear. Depending on the results of bacterial cultures, the lesions were divided into two groups and the efficacy of glucantime was compared.Results:A total of 123 patients (76.4%) were negative, and 38 patients (23.6%) were positive for secondary bacterial infection. In groups with negative bacterial culture response to treatment was 65% (80 patients) and in the other positive group, it was 31.6% (12 patients), with a difference (χ2 = 13.77, P < 0.01).Conclusion:Therapeutic effect of glucantime showed a decrease in CL lesions with secondary bacterial infection. Therefore, in the cases of unresponsiveness to treatment, the lesions should be evaluated for bacterial infection, before repeating the treatment.

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Section: Discussionmentioning

confidence: 84%

Decreased effect of glucantime in cutaneous leishmaniasis complicated with secondary bacterial infection

et al. 2011

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“…Bacterial superinfection is a known complication of CL lesions, with an incidence of 21.8% in one series. 57 The lengthy time to heal in this patient with bacterial superinfection (7 months) is not unexpected, because coinfection reduces the rate of elimination of bacteria and enhances the severity of CL skin lesions. 58 After the patient was treated with antibiotics, her CL lesion improved considerably, and she was without relapse for 36 months post-liposomal amphotericin B treatment.…”

Section: -56mentioning

confidence: 77%

A Species-Specific Approach to the Use of Non-Antimony Treatments for Cutaneous Leishmaniasis

Ramanathan

Talaat

Fedorko

et al. 2011

The American Journal of Tropical Medicine and Hygiene

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“…The lesions may progress into well-delimited ulcers with raised edges [ 3 ]. LCL can present with open lesions (wet lesions), which are subject to superficial secondary infection by bacterial or fungal species, with Staphylococcal species being most common [ 53 ]. For reasons that are still under debate, lesion ulceration has been associated lesion healing [ 54 ].…”

Section: Localized Cutaneous Leishmaniasismentioning

confidence: 99%

Cutaneous Manifestations of Human and Murine Leishmaniasis

Scorza

Carvalho

Wilson

2017

IJMS

164

136

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The leishmaniases are diseases caused by pathogenic protozoan parasites of the genus Leishmania. Infections are initiated when a sand fly vector inoculates Leishmania parasites into the skin of a mammalian host. Leishmania causes a spectrum of inflammatory cutaneous disease manifestations. The type of cutaneous pathology is determined in part by the infecting Leishmania species, but also by a combination of inflammatory and anti-inflammatory host immune response factors resulting in different clinical outcomes. This review discusses the distinct cutaneous syndromes described in humans, and current knowledge of the inflammatory responses associated with divergent cutaneous pathologic responses to different Leishmania species. The contribution of key hematopoietic cells in experimental cutaneous leishmaniasis in mouse models are also reviewed and compared with those observed during human infection. We hypothesize that local skin events influence the ensuing adaptive immune response to Leishmania spp. infections, and that the balance between inflammatory and regulatory factors induced by infection are critical for determining cutaneous pathology and outcome of infection.

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Distribution Frequency of Pathogenic Bacteria Isolated from Cutaneus Leishmaniasis Lesions

Cited by 21 publications

References 5 publications

Decreased effect of glucantime in cutaneous leishmaniasis complicated with secondary bacterial infection

Decreased effect of glucantime in cutaneous leishmaniasis complicated with secondary bacterial infection

A Species-Specific Approach to the Use of Non-Antimony Treatments for Cutaneous Leishmaniasis

Cutaneous Manifestations of Human and Murine Leishmaniasis

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