Distribution-Free Statistical Tests

BRADLEY, JAMES V.

doi:10.21236/ad0249268

Cited by 413 publications

(513 citation statements)

References 0 publications

Supporting

Mentioning

503

Contrasting

Unclassified

Order By: Relevance

“…22 For comparison of three or more groups, the nonparametric Kruskal-Wallis' ANOVA 23 was used and Tukey's range test was utilized for post hoc testing of differences between mean values. 24 Correlations between variables were tested using Pitman's nonparametric permutation test 22 and Pearson's correlation coefficients were calculated for descriptive purposes. The limit for significance was set at the 5% level.…”

Section: Methodsmentioning

confidence: 99%

Ten-year trends in health-related quality of life after surgical and conventional treatment for severe obesity: the SOS intervention study

et al. 2007

View full text Add to dashboard Cite

Objective: To examine trends and effects of weight loss treatment on health-related quality of life (HRQL) in the severely obese over 10 years. Design: Swedish obese subjects (SOS) intervention study is a controlled, longitudinal trial of the health effects of weight loss in the severely obese. Subjects: A total of 655 of 851 surgically treated and 621 of 852 conventionally treated obese men (body mass index, BMIX34) and women (BMIX38) who completed 10 years of the study. Measurements: HRQL was assessed before treatment and after 0.5, 1, 2, 3, 4, 6, 8 and 10 years. Results: HRQL change during the 10-year observation period largely followed phases of weight loss, weight regain and weight stability. Improvements and deteriorations in HRQL were associated with the magnitude of weight loss or regain, except regarding anxiety. Peak improvements in the surgical group were observed during the first year of weight loss, whereas the weight regain phase (mainly between 1-and 6-year follow-up) was accompanied by a gradual decline in HRQL. The period from 6-to 10-year follow-up was characterized by relatively stable observations in both weight and HRQL. At 10 years, net gains were noted in all HRQL domains compared to baseline. Comparisons of treatment effects on HRQL in the surgical vs conventional group after 10 years showed significantly better outcome in the surgical group on current health perceptions, social interaction, psychosocial functioning and depression, whereas no significant differences were found for overall mood and anxiety. Long-term results of the study suggest that a maintained weight loss of about 10% is sufficient for positive long-term effects on HRQL, a limit that was reached in about two-thirds of the surgically treated patients who completed 10 years of the study. Conclusion: Long-lasting weight reduction in the severely obese has a general long-standing positive outcome on HRQL. Bariatric surgery is a favorable option for the treatment of severe obesity, resulting in long-term weight loss and HRQL improvements in a majority of patients. However, difficulties among some surgical patients to control and maintain weight loss over time should not be ignored. Future research should study if the long-term efficacy of bariatric surgery may be further enhanced by implementing lifestyle modification techniques in the postoperative management of patients.

show abstract

Section: Methodsmentioning

confidence: 99%

Ten-year trends in health-related quality of life after surgical and conventional treatment for severe obesity: the SOS intervention study

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Standard methodology was applied for construct validation of scaling procedures including the calculation of Cronbach's alpha and principal components (Nunnally, 1978). Fischer's non-parametric permutation test was used for the significance testing of differences between groups (Bradley, 1968).…”

Section: Methodsmentioning

confidence: 99%

Sexual ability, activity, attitudes and satisfaction as part of adjustment in spinal cord-injured subjects

Siösteen¹,

Lundqvist

Blomstrand

et al. 1990

Spinal Cord

View full text Add to dashboard Cite

SummaryChanges in different aspects of sexuality were investigated and related to overall quality of life and physical, psychological and social adjustment in 73 SCI subjects, who were sexually active both before and after injury. Items on sexual interest and satisfaction were treated as one composite variable, the SIS scale, measuring sexual adjustment after injury.Despite severe genital dysfunction, more than half of the subjects (57%) rated their sexual relations after injury as satisfying or at least rather satisfying. The majority continued having intercourse, although many of them more seldom than before, and about half experienced orgasm.Sexual adjustment after injury was closely and positively correlated to frequency of intercourse, willingness to experiment with alternative sexual expressions and young age at injury. Physical and social independence and a high mood level were further positive determinants of sexual adaptation after injury, whereas the neurological level and completeness of injury showed no significant correlation with sexuality.It is suggested that sexual information and counselling should be integrated in the total care of the SCI patient to reduce the negative effects on sexuality, caused by the lnJury.

show abstract

“…An evaluation of the quality of the fit for the various kinetic models was done as described elsewhere (30) by calculating three statistical values: the standard deviation of the residuals (S.D. ), the "+ or -signs" statistic (Z1) and the "Run up and down" statistic (Z2) (33).…”

Section: Spr Experiments (A) Immobilization Of K Coils On Sensormentioning

confidence: 99%

Real-Time Monitoring of the Interactions of Two-Stranded de Novo Designed Coiled-Coils: Effect of Chain Length on the Kinetic and Thermodynamic Constants of Binding

et al. 2003

View full text Add to dashboard Cite

We have de novo designed a heterodimeric coiled-coil formed by two peptides as a capture/ delivery system that can be used in applications such as affinity tag purification, immobilization in biosensors, etc. The two strands are designated as K coil (KVSALKE heptad sequence) and E coil (EVSALEK heptad sequence), where positively charged or negatively charged residues occupy positions e and g of the heptad repeat. In this study, for each E coil or K coil, three peptides were synthesized with lengths varying from three to five heptads. The effect of the chain length of each partner upon the kinetic and thermodynamic constants of interaction were determined using a surface plasmon resonance-based biosensor. Global fitting of the interactions revealed that the E5 coil interacted with the K5 coil according to a simple binding model. All the other interactions involving shorter coils were better described by a more complex kinetic model involving a rate-limiting reorganization of the coiled-coil structure. The affinities of these de novo designed coiled-coil interactions were found to range from 60 pM (E5/K5) to 30 µM (E3/K3). From these K d values, we were able to determine the free energy contribution of each heptad, depending on its relative position within the coiled-coils. We found that the free energy contribution of a heptad occupying a central position was 3-fold higher than that of a heptad at either end of the coiled-coil. The wide range of stabilities and affinities for the E/K coil system provides considerable flexibility for protein engineering and biotechnological applications.The R-helical coiled-coil is an oligomerization domain that is naturally present in a wide variety of proteins such as transcription factors, cytoskeletal proteins, motor proteins, and viral fusion proteins (1-3). The structural properties of coiled-coils have been extensively characterized from numerous high-resolution crystal and NMR structures (3-5). The formation of coiled-coils requires the wrapping of two or more amphipathic R-helices around each other in a lefthanded supercoil fashion; the helices may be aligned in either a parallel or antiparallel manner. The R-helices composing the coiled-coil structure are defined by a heptad repeat (denoted abcdefg) in which hydrophobic residues occupy the positions a and d and pack in a characteristic "knobs-intoholes" manner (6), forming the hydrophobic core ( Figure 1). Many studies (1,(7)(8)(9)(10)(11)(12) emphasized the role of charged residues (typically in the e and g positions) in controlling the specificity of oligomerization and opened up the way to the de novo design of heterodimeric coiled-coils (13-17). Their relatively small size, in addition to their well-defined structure, make coiled-coils a very attractive system for protein engineering and biotechnological applications (5, 18) such as the construction of miniaturized antibodies, the control of signaling protein domain oligomerization, and the specific targeting of GFP to cytoskeletal proteins (see ref 4 for ...

show abstract

Distribution-Free Statistical Tests

Abstract: As a result of an extensive survey of the literature, a large number of distribution-free statistical tests are examined. Tests are grouped together primarily according to general type of mathematical derivation or type of statistical "information" used in'conducting the test. Each

Cited by 413 publications

References 0 publications

Ten-year trends in health-related quality of life after surgical and conventional treatment for severe obesity: the SOS intervention study

Ten-year trends in health-related quality of life after surgical and conventional treatment for severe obesity: the SOS intervention study

Sexual ability, activity, attitudes and satisfaction as part of adjustment in spinal cord-injured subjects

Real-Time Monitoring of the Interactions of Two-Stranded de Novo Designed Coiled-Coils: Effect of Chain Length on the Kinetic and Thermodynamic Constants of Binding

Contact Info

Product

Resources

About