Distribution, ecology, and immunosuppressive properties of Tricholoma populinum (basidiomycetes)

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“…Regression of severe allergic symptoms was observed in a patient suffering from thromboangitis obliterans and also in a patient with urticaria. The compound known as ergosterol peroxide confirmed the effects in a study conducted in an animal model 23,49 . Hispolon and hispidin extracted from fruiting bodies of mushroom I. hispidus showed inhibition of chemiluminescence response of human mononuclear blood cells and mitogen-induced proliferation of spleen lymphocytes of mice 50 .…”

“…To survive in the natural environment, many antibacterial and antifungal compounds are naturally present in mushrooms. It is a well-known fact, that some compounds from microscopic fungi are marketed as antibiotics till date 13 . A recent upsurge in interest was noticed among various researchers regarding the antimicrobial action of the bioactive compounds showing action against multidrug-resistant bacteria.…”

The Pharmacological Potential of Mushrooms

“…Eating of Tricholoma populinum J. E. Lange led to the regression of severe allergic symptoms in a patient with thromboangitis obliterans and in another patient with urticaria. The effects could be confirmed in animal models, as one responsible compound ergosterol peroxide ( 4 ) was identified (101,102). Hispolon ( 15 ) and hispidin ( 16 ), isolated from fruit bodies of I. hispidus, inhibit the chemiluminescence response of human mononuclear blood cells and the mitogen-induced proliferation of spleen lymphocytes of mice (103).…”

Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells

“…Despite various biological effects of EP such as immunosuppressive [6-8], anti-viral [9], anti-inflammatory [10] and anti-tumor [5,10] activities, the underlying molecular mechanisms for anti-cancer activity of EP still remain unclear.…”