Distribution coefficients and cation exchange behavior of elements in hydrochloric acid-acetone

Strelow, F.W.E.; Victor, A.H.; Zyl, C.R. Van; Eloff, Cynthia.

doi:10.1021/ac60302a015

Cited by 115 publications

(44 citation statements)

References 11 publications

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“…The procedures described here for Mg purication and analysis are optimized to handle considerably smaller samples than previous high-precision Mg Al/ 24 Mg ratio of 13.5) to <1&. Thus, for typical 5 mg Mg required for high-precision isotope analysis following the present analytical procedures, this corresponds to a maximum blank level of 5 ng Mg (Fig.…”

Section: Accuracy and Reproducibility Of Mg Isotope Measurementsmentioning

confidence: 95%

“…This was followed by Mn elution using a 95% acetone + 0.5 M HCl mixture. 24 Calcium was nally separated from the residual sample matrix by unloading Mg, Ca, Ni, Cr, Na and K from the cation exchanger using 10 ml of 3 M HNO 3 and eluting directly onto a pre-cleaned faster-owing Bio-Rad column containing 0.7 ml DGA-N (TrisKem) resin. The high affinity of Ca for the DGA resin in 3 M HNO 3 (ref.…”

Section: In-line Chromatographic Separation and Purication Of Mg And Timentioning

confidence: 99%

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Multi-element ion-exchange chromatography and high-precision MC-ICP-MS isotope analysis of Mg and Ti from sub-mm-sized meteorite inclusions

Larsen

Wielandt

Bizzarro

2018

J. Anal. At. Spectrom.

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The analytical improvement of new generation mass spectrometers has reached a level required for highprecision isotope analysis of very small and unique natural samples. The multi-element isotopic signatures of meteorite inclusions can potentially provide detailed insight into the origin of our solar system. As such, in-line separation and isotope analysis of multiple elements from such unique samples is highly desirable, but rarely accommodated by current chromatographic purification procedures necessary for accurate isotope analysis using multiple collector inductively coupled plasma source mass spectrometry (MC-ICP-MS). Here, we report a new multi-element ion chromatographic purification procedure, specifically Ti* defined by inner solar system materials, suggesting residual nucleosynthetic effects in CAI precursors.

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Section: Accuracy and Reproducibility Of Mg Isotope Measurementsmentioning

confidence: 95%

Section: In-line Chromatographic Separation and Purication Of Mg And Timentioning

confidence: 99%

Multi-element ion-exchange chromatography and high-precision MC-ICP-MS isotope analysis of Mg and Ti from sub-mm-sized meteorite inclusions

Larsen

Wielandt

Bizzarro

2018

J. Anal. At. Spectrom.

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“…Due to high distribution coefficients, generator-produced 68 Ga can be quantitatively adsorbed on the resin directly from the generator eluate. Literature data indicate that, with the increase of the content of acetone in the HCl solutions of the same acid concentration, the affinity of 68 Ga for the organic cation-exchange resin decreases (11,12). Consequently, systematic experiments have been performed in the present study to adapt this approach for processing generator-produced 68 Ga.…”

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confidence: 99%

Processing of Generator-Produced 68Ga for Medical Application

Zhernosekov¹,

Filosofov²,

Baüm³

et al. 2007

Journal of Nuclear Medicine

455

348

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The 68 Ge/ 68 Ga generator provides an excellent source of positron-emitting 68 Ga. However, newly available ''ionic'' 68 Ge/ 68 Ga radionuclide generators are not necessarily optimized for the synthesis of 68 Ga-labeled radiopharmaceuticals. The eluates have rather large volumes, a high concentration of H 1 (pH of 1), a breakthrough of 68 Ge, increasing with time or frequency of use, and impurities such as stable Zn(II) generated by the decay of 68 Ga, Ti(IV) as a constituent of the column material, and Fe(III) as a general impurity. Methods: We have developed an efficient route for the processing of generator-derived 68 Ga eluates, including the labeling and purification of biomolecules. Preconcentration and purification of the initial generator eluate are performed using a miniaturized column with organic cationexchanger resin and hydrochloric acid/acetone eluent. The purified fraction was used for the labeling of nanomolar amounts of octreotide derivatives either in pure aqueous solution or in buffers. Results: Using the generator post-eluate processing system, .97% of the initially eluated 68 Ga activity was obtained within 4 min as a 0.4-mL volume of a hydrochloric acid/acetone fraction. The initial amount of 68 Ge(IV) was decreased by a factor of 10 4 , whereas initial amounts of Zn(II), Ti(IV), and Fe(III) were reduced by factors of 10 5 , 10 2 , and 10, respectively. The processed 68 Ga fraction was directly transferred to solutions containing labeling precursors-for example, DOTA-DPhe 1 -Tyr 3 -octreotide (DOTATOC) (DOTA 5 1,4,7,N9, N99,. Labeling yields of .95% were achieved within 10 min. Overall yields reached 70% at 20 min after generator elution relative to the eluted 68 Ga activity, not corrected for decay. Specific activities of 68 Ga-DOTATOC were 50 MBq/nmol using a standard protocol, reaching 450 MBq/nmol under optimized conditions. Conclusion: Processing on a cation-exchanger in hydrochloric acid/acetone media represents an efficient strategy for the concentration and purification of generator-derived 68 Ga(III) eluates. The developed scheme guarantees high yields and safe preparation of injectable 68 Ga-labeled radiopharmaceuticals for routine application and is easy to automate. Thus, it is being successfully used in clinical environments and might contribute to a new direction for clinical PET, which could benefit significantly from the easy and safe availability of the radionuclide generatorderived metallic positron-emitter 68 Ga. Zn. 68 Ga is an excellent positron emitter, with 89% positron branching accompanied by low photon emission (1,077 keV, 3.22%) (1,2). 68 Ge/ 68 Ga radionuclide generators have been the object of development and investigation for almost 50 y. For a recent review on this and other PET radionuclide generator systems see Rösch et al. (3).Today, the most common commercially available 68 Ge/ 68 Ga radionuclide generator is based on a TiO 2 solid phase (Cyclotron Co. Ltd.) (4). The generators are produced with 68 Ge activities of up to 3.7 GBq. ''Ionic'' 68 Ga 31...

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“…Quitté and Oberli, 2006;Cameron and Vance, 2011). Alternatively, cation chromatography using a mixed HCl-acetone eluent (Strelow et al 1971) has also been successfully used (e.g. Tang and Dauphas, 2012).…”

mentioning

confidence: 99%