Distribution characteristics of immunoglobulin-secreting cells in adenoids. Relationship to age and disease

Nadal, David; Soh, Nobuaki; Schläpfer, Erika; Bernstein, Joel; Ogra, Pearay L.

doi:10.1016/0165-5876(92)90138-f

Cited by 17 publications

(13 citation statements)

References 6 publications

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“…Although IgA ASC numbers were reported to increase in tonsillar cells after influenza vaccination, they were likely to represent mainly a primary rather than a memory IgA response (49). The predominance of antigen-specific IgG memory B cell responses to influenza virus HA in tonsillar tissues shown in this study is concordant with previous studies demonstrating the predominance of IgG memory B cell responses to protein antigens in human NALT (18,19,21).…”

Section: Discussionsupporting

confidence: 82%

“…However, studies have shown there are some major differences between human NALT in the nasopharynx and other mucosal compartments such as Peyer's patches in the intestine. B cells in the former predominantly produce IgG, whereas the majority of B cells in the latter produce IgA (18,19). We demonstrated previously that pneumococcal protein antigens elicited a predominantly IgG memory B cell response in human NALT presumably primed by previous colonization (20,21).…”

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confidence: 99%

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Infection with 2009 H1N1 Influenza Virus Primes for Immunological Memory in Human Nose-Associated Lymphoid Tissue, Offering Cross-Reactive Immunity to H1N1 and Avian H5N1 Viruses

Mahallawi

Kasbekar

McCormick

et al. 2013

J Virol

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Section: Discussionsupporting

confidence: 82%

mentioning

confidence: 99%

Infection with 2009 H1N1 Influenza Virus Primes for Immunological Memory in Human Nose-Associated Lymphoid Tissue, Offering Cross-Reactive Immunity to H1N1 and Avian H5N1 Viruses

Mahallawi

Kasbekar

McCormick

et al. 2013

J Virol

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“…It not only induces Ig switch and retains memory B cells (35) but also promotes survival of plasma cells. The preferential production of IgA and IgG in gut and tonsil, respectively, has been known for decades (36,37). In situ specific switch factors are involved in this process (16,17,38).…”

Section: Discussionmentioning

confidence: 99%

APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa

Huard¹,

Mckee²,

Bosshard³

et al. 2008

J. Clin. Invest.

142

140

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The bone marrow constitutes a favorable environment for long-lived antibody-secreting plasma cells, providing blood-circulating antibody. Plasma cells are also present in mucosa-associated lymphoid tissue (MALT) to mediate local frontline immunity, but how plasma cell survival there is regulated is not known. Here we report that a proliferation-inducing ligand (APRIL) promoted survival of human upper and lower MALT plasma cells by upregulating expression of the antiapoptotic proteins bcl-2, bcl-x L , and mcl-1. The in situ localization of APRIL was consistent with such a prosurvival role in MALT. In upper MALT, tonsillar epithelium produced APRIL. Upon infection, APRIL production increased considerably when APRIL-secreting neutrophils recruited from the blood infiltrated the crypt epithelium. Heparan sulfate proteoglycans (HSPGs) retained secreted APRIL in the subepithelium of the infected zone to create APRIL-rich niches, wherein IgG-producing plasma cells accumulated. In lower MALT, neutrophils were the unique source of APRIL, giving rise to similar niches for IgA-producing plasmocytes in villi of lamina propria. Furthermore, we found that mucosal humoral immunity in APRIL-deficient mice is less persistent than in WT mice. Hence, production of APRIL by inflammation-recruited neutrophils may create plasma cell niches in MALT to sustain a local antibody production.

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“…Involution of the tonsils has been associated with a decrease in the synthesis of DNA [8] and a decrease in cell proliferation [9]. A decrease in the relative amount of B lymphocytes [10], a decrease in the production of immunoglobulins [11], and a decrease in the number and size of lymphoid follicles as evaluated microscopy [12] have also been reported.…”

Section: Introductionmentioning

confidence: 99%

Age‐Associated Changes in the Cellular Composition of the Human Adenoid

Mattila

Tarkkanen

1997

Scand J Immunol

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Mattila PS, Tarkkanen J. Age-Associated Changes in the Cellular Composition of the Human Adenoid. Scand J Immunol 1997;45:423-427 Histological investigations suggest that the size and number of lymphoid follicles of the adenoids and tonsils decrease during ageing. The mechanisms underlying the histological changes are unknown. The authors have analysed the frequency of lymphocyte subpopulations in the adenoids by flow cytometry. The proportion of B lymphocytes decreased and the proportion of T lymphocytes of all mononuclear cells increased with age. Of all B lymphocytes the proportion of CD38 þ , surface IgD ¹ B lymphocytes representing the germinal centre cell phenotype, decreased and the proportion of CD38 ¹ , IgD ¹ B lymphocytes representing the mature B lymphocyte phenotype, increased with age. The expression of CD23, a cell surface molecule associated with activation of follicular mantle IgD þ B lymphocytes, did not change with increasing age. The results imply that the involution of the adenoid is associated with a decreased germinal centre reaction and relative accumulation of mature B cells in the adenoidal tissue, as analysed by three-colour flow cytometry.

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Distribution characteristics of immunoglobulin-secreting cells in adenoids. Relationship to age and disease

Cited by 17 publications

References 6 publications

Infection with 2009 H1N1 Influenza Virus Primes for Immunological Memory in Human Nose-Associated Lymphoid Tissue, Offering Cross-Reactive Immunity to H1N1 and Avian H5N1 Viruses

Infection with 2009 H1N1 Influenza Virus Primes for Immunological Memory in Human Nose-Associated Lymphoid Tissue, Offering Cross-Reactive Immunity to H1N1 and Avian H5N1 Viruses

APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa

Age‐Associated Changes in the Cellular Composition of the Human Adenoid

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