Distribution Characteristics and Combined Effect of Polymorphisms Affecting Alcohol Consumption Behaviour in the Hungarian General and Roma Populations

Diószegi, Judit; Fiatal, Szilvia; Tóth, Réka; Moravcsik-Kornyicki, Ágota; Kósa, Zsigmond; Sándor, János; Ádány, Róza

doi:10.1093/alcalc/agw052

Cited by 13 publications

(12 citation statements)

References 29 publications

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“…effects beyond increased susceptibilities to some rare health conditions (e.g. Diószegi et al 2017;Fiatal et al 2016;Iovita et al 2004;Kalaydjieva et al 2001;Martinez-Cruz et al 2016;Pikó et al 2017;Szalai et al 2014). This is in line with findings on other ethnic disparities in indicating complex reproductive segregation patterns faced by minority ethnic groups (Bhopal 2015;Dressler et al 2005;Smith 2000).…”

Section: Figure 12 Health Indicators For Roma and The General Populasupporting

confidence: 64%

“…Accordingly, and alike for other ethnic health-disparities (Diez Roux 2012; Dressler et al 2005), the insignificance of genetic influences behind poor Roma health status has been confirmed empirically. The only genetic susceptibilities identified in Roma are higher frequencies of a handful of gene-alleles causing rare diseases, peaking in some localities due to total social (reproductive) segregation from neighbouring Chapter 7 populations (Diószegi et al 2017;Fiatal et al 2016;Kalaydjieva et al 2001;Martinez-Cruz et al 2016). Let's emphasize that this is despite a previous disproportionate focus of research specifically on possible genetic influences (Hajioff and McKee 2000;Zeman et al 2003).…”

Section: Why Should Genes Come Last?mentioning

confidence: 99%

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The health of segregated Roma: first-line views and practices: a case study in Slovakia using ethnographic methods

Belák¹

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Segregated Roma are also being oppressed through their self-exclusionary hopes and tastes. Chapter 3 of this thesis 2. Pushed and pulled towards the so-called margins, most segregated Roma become skilled at escaping the relative disadvantages of life standard in the so-called centers. Chapter 4 of this thesis 3. Many people who happen to serve segregated Roma feel that such position gradually forces them to choose between useless burnout and cynical neglect. Chapter 5 of this thesis 4. Trusting segregated Roma with more decision power and resources causes many of them to challenge the local structures that oppress them. Chapter 6 of this thesis 5. It would require a rather explicit selection process to make any risky genes concentrate in any Roma group-much more selective than Roma history could lead to. Chapter 7 of this thesis 6. Antigypsyism drives the poor health status of the Roma, mostly because most people involved, including segregated Roma, do not understand that it is so. Discussion of this thesis 7. We cannot claim to have formulated a convincing denial of the inequality of the human races, so long as we fail to consider the problem of the inequality-or diversity-of human cultures, which is in fact-however unjustifiably-closely associated with it in the public mind. Claude Levi-Strauss 8. We're all going to die, all of us, what a circus! That alone should make us love each other but it doesn't. We are terrorized and flattened by trivialities, we are eaten up by nothing. Charles Bukowski 9. We live in a world where we have to hide to make love, while violence is practiced in broad daylight. John Lennon 10. We are lost, but other animals point to the right road. They are the right road.

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Section: Figure 12 Health Indicators For Roma and The General Populasupporting

confidence: 64%

Section: Why Should Genes Come Last?mentioning

confidence: 99%

The health of segregated Roma: first-line views and practices: a case study in Slovakia using ethnographic methods

Belák¹

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“…Similar results have been described for Slovak patients undergoing coronary angiography (34) -in this study, authors also report lower alcohol intake for Gypsies/Roma subjects in comparison with the majority population. Finally, the identical drinking pattern was observed in the Hungarian Gypsies/Roma population (32).…”

Section: Gypsies/roma Population (N = 285)supporting

confidence: 64%

“…In summary, in comparison with the majority population, lower alcohol intake in the Gypsies/Roma minority has been reported in the Czech Republic, Slovakia and Hungary, but not in Gypsies/ Roma minorities inhabiting Western European regions (32). We can however speculate that the much lower socioeconomic status of this minority (which is also valid for the majority population) in non-Western European regions could be one of the reasons for this difference.…”

Section: Gypsies/roma Population (N = 285)mentioning

confidence: 55%

Distribution of ADH1B genotypes predisposed to enhanced alcohol consumption in the Czech Roma/Gypsy population

Hubáček¹,

Šedová²,

Olišarová³

et al. 2018

Cent Eur J Public Health

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Objective: The aim of the study was to analyse the frequencies of rs1229984 genotypes within the alcohol dehydrogenase (ADH1B) gene in a Gypsies/Roma population and compare them with other populations and with ethanol consumption. Methods: We analysed the ADH1B (rs1229984; Arg47→His; c.143G>A) genotype using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) in two ethnically different groups-Gypsies/Roma (N = 301) and Czechs (N = 300) where one day alcohol consumption was recorded. Results: ADH1B genotype/allelic frequencies did not significantly differ between the populations (p = 0.32). The frequency of minor A allele carriers was slightly higher in Gypsies/Roma (14.7%) than in Czechs (11.9%). The prevalence of subjects reporting alcohol intake on the previous day was non-significantly lower in Gypsies/Roma (10.5% vs. 16.4%), as was the amount of alcohol consumed the day before the examination in ethanol consumers (36.1 ± 18.3 g vs. 43.0 ± 27.2 g). Conclusions: The frequency of rs1229984 genotypes in the ADH1B gene within the Gypsies/Roma population corresponds with frequencies obtained in North India/Central Asia, the putative country of this ethnic origin. Our results suggest that the minority Gypsies/Roma population consume slightly less alcohol than the Czech majority population.

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“…Heritability in alcohol dependence is independent of gender and is estimated to range from 40 to 70% based on twin and adoption studies [ 10 , 48 ]. Most of the genes and their polymorphisms that have been linked to alcohol dependence both in a predisposing as well as a protective way are related to alcohol metabolism and neurotransmission [ 7 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

The prevalence of ADH1B and OPRM1 alleles predisposing for alcohol consumption are increased in the Hungarian psoriasis population

et al. 2019

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Alcohol intake affects in great the symptoms and life of psoriasis patients, although the association of SNPs related to increased alcohol consumption with psoriasis has not been elucidated. Therefore, to investigate the association of psoriasis with established alcohol consumption and dependence-related gene variants we conducted a population-based case–control study including 3743 subjects (776 psoriasis cases and 2967 controls from the general Hungarian population). Genotyping of 23 SNPs at ADH1B, ADH1C, ALDH1A1, ALDH2, SLC6A3, DDC, GABRA2, GABRG1, HTR1B, MAOA, TPH2, CHRM2, GRIN2A, POMC, OPRM1, OPRK1 and BDNF were determined and differences in genotype and allele distributions were investigated. Multiple logistic regression analyses were implemented. Analysis revealed association between C allele of the rs1229984 polymorphism ( ADH1B gene) and psoriasis risk (OR additive = 1.58, 95% CI 1.23–2.03, p < 0.001, OR recessive = 1.58, 95% CI 1.22–2.04, p = 0.001). Furthermore, the G allele of rs1799971 polymorphism ( OPRM1 gene) increased the risk of familial aggregation (OR additive = 1.99, 95% CI 1.36–2.91, p < 0.001 OR dominant = 2.01, 95% CI 1.35–3.01, p < 0.001). In subgroups of psoriatic patients with history of early onset and familial aggregation effect allele ‘C’ of rs1229984 showed association in the additive and recessive models (OR additive = 2.41, 95% CI 1.26–4.61, p < 0.01, OR recessive = 2.42, 95% CI 1.26–4.68, p < 0.01). While effect allele ‘G’ of rs1799971 ( OPRM1 ) also associated with increased risk of early onset and familial aggregation of psoriasis in the additive and dominant models (OR additive = 1.75, 95% CI 1.27–2.43, p = 0.001, OR dominant = 1.82, 95% CI 1.26–2.63, p = 0.001). Our results suggest that genetically defined high-risk individuals for alcohol consumption are more common in the psoriasis population. Electronic supplementary material The online version of this article (10.1007/s00403-019-01915-y) contains supplementary material, which is available to authorized users.

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Distribution Characteristics and Combined Effect of Polymorphisms Affecting Alcohol Consumption Behaviour in the Hungarian General and Roma Populations

Cited by 13 publications

References 29 publications

The health of segregated Roma: first-line views and practices: a case study in Slovakia using ethnographic methods

The health of segregated Roma: first-line views and practices: a case study in Slovakia using ethnographic methods

Distribution of ADH1B genotypes predisposed to enhanced alcohol consumption in the Czech Roma/Gypsy population

The prevalence of ADH1B and OPRM1 alleles predisposing for alcohol consumption are increased in the Hungarian psoriasis population

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