Distribution and Removal of Monomeric and Polymeric Plutonium in Rats and Mice

Comparative tissue uptake and cellular deposition of three different plutonium chemical forms in rats

“…Liver retention is lower after contamination with Pu citrate than with Pu nitrate and the distribution within this organ appears homogeneous for Pu citrate, whereas accumulation spots are observed for Pu nitrate. The results are in accordance with those published after biokinetic and autoradiograph analyses (Markley et al 1964, Lindenbaum and Rosenthal 1972, Lindenbaum and Russell 1972, Gearhart et al 1980). The differences in Pu distribution observed between Pu citrate and Pu nitrate might be explained by the binding of Pu to the biological ligands and/or by a different cellular localization of the actinide.…”

“…Previous experiments have reported biological behaviour after contamination with monomeric or polymeric forms of Pu in laboratory animals (Markley et al 1964, Grube et al 1978, Taylor et al 1991, Durbin et al 1997. However, only few studies are available on the distribution of Pu within liver cells, according to the physical and chemical properties of the actinide.…”

Comparison of plutonium systemic distribution in rats and dogs with published data in humans

“…Ballou et al (1967) performed a study in rats, in which 2.9 ϫ 10 6 Bq.kg Ϫ1 of monomeric 239 Pu ϩ 4 -citrate was intravenously injected to rats; 36% of the administered material was found in liver whereas only 18% was found in skeleton. Comparing the biokinectic data reported by Markley et al (1964) and Ballou et al (1967), it is observed that for the same physicochemical form, the 239 Pu ϩ 4 distribution in skeleton and liver was modifi ed by the administered mass of 239 Pu.In Table I are presented the biokinetic data available in the literature for intravenous injection of monomeric 239 Pu ϩ 4 -citrate in rats and dogs at similar activity concentrations. Th e data available for each species are very scarce; Markley et al (1964) have reported data for three timepoints (3, 6 and 12 d) for rat ' s study; Stevens et al (1975) have reported data for one time-point, 14 d for a dog ' s study ;and Stover et al (1959) reported data for six time-points for another dog ' s study, but starting at 29 d after injection.…”

“…Comparing the biokinectic data reported by Markley et al (1964) and Ballou et al (1967), it is observed that for the same physicochemical form, the 239 Pu ϩ 4 distribution in skeleton and liver was modifi ed by the administered mass of 239 Pu.…”

“…Ballou et al (1967) performed a study in rats, in which 2.9 ϫ 10 6 Bq.kg Ϫ1 of monomeric 239 Pu ϩ 4 -citrate was intravenously injected to rats; 36% of the administered material was found in liver whereas only 18% was found in skeleton. Comparing the biokinectic data reported by Markley et al (1964) and Ballou et al (1967), it is observed that for the same physicochemical form, the 239 Pu ϩ 4 distribution in skeleton and liver was modifi ed by the administered mass of 239 Pu.…”