Distribution and quantification of elements of the enteric nervous system in the distal rectum of neonates and infants

Leštarević, S.; Lazić, Minja Miličić; Janković, Radmila

doi:10.1016/j.pbj.2017.07.059

Cited by 1 publication

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“…Submukozni pleksus, kao što mu ime govori, nalazi se u submukozi, dok se mijenterički pleksus nalazi između longitudinalnog i cirkularnog mišićnog sloja zida digestivne cevi (slika 1) (2). Za razliku od submukoznog pleksusa, koji nedostaje u jednjaku, mijenterički pleksus prisutan je čitavom dužinom digestivnog trakta (2,3). Svi neuroni ENS, tokom međusobnih interakcija i primanja spoljašnjih signala, pre svega od drugih delova nervnog sistema, ostvaruju brojne, vitalno važne funkcije u našem organizmu.…”

Section: Uvodunclassified

“…The submucous plexus, as its name implies, is located in the submucosa while the myenteric plexus is situated between the longitudinal and circular muscle layer in the digestive tract (Figure 1) (2). In contrast to the submucous plexus, which is not found in the esophagus, the myenteric plexus extends the entire length of the digestive tract (2,3). All neurons of the ENS, with their mutual interactions and extrinsic inputs, primarily from other parts of the nervous system, regulate numerous, vital functions in our body.…”

Section: Introductionmentioning

confidence: 99%

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Origin of enteric nervous system cells and migration pathways during embryonic development

Đuknić¹,

Puškaš²,

Labudović‐Borović³

et al. 2022

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The enteric nervous system (ENS) is represented by a complex network of neurons, glial and other cells within the wall of the digestive tract. ENS is responsible for numerous, vital functions in our body. Thus, ENS regulates motility of the digestive tract, secretion into the intestinal lumen, exchange of fluid and electrolytes through the mucosa, as well as mucosal perfusion. In order to perform these important functions, proper embryonic development of ENS is necessary. ENS cells are derived from precursor cells of the neural crest (NCCs - neural crest cells). Two cell populations that contribute to the largest number of future ENS cells are the vagal and sacral NCCs. Vagal NCCs enter the primitive gut tube in the region of the future esophagus (foregut), and begin their migration, through the midgut towards the hindgut and the future anal region. Sacral NCCs enter the hindgut region following the extrinsic nerve fibers and continue their migration rostrally, towards vagal NCCs. Along with the migration process, these cells undergo other important processes, such as proliferation, neuro-glial differentiation, gangliogenesis, axonal pathway formation and synaptogenesis. All these processes are strictly regulated by numerous signaling pathways, which are still being actively researched. Modern lineage tracing and other technologies, that enabled following of individual precursor cells through their development pathways, will significantly contribute to the better understanding of development of ENS. This may have repercussions in improving the diagnosis and treatment of some developmental (Hirschsprung disease) and other ENS disorders.

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Section: Uvodunclassified

Section: Introductionmentioning

confidence: 99%