Distribution and Prevalence of Antimicrobial Resistance of NTS Salmonella Isolated from Farm Animals and Animal Food Products in Africa

Zahra, Bellil; Mairi, Assia; Touati, Abdelaziz

doi:10.1007/978-3-031-23796-6_5

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…Some Salmonella serovars are known to be associated with specific sources [62]. S. Derby, S. Montevideo and S. Kottbus have often been linked to pig, cattle, and poultry production systems, respectively [63].…”

Section: Plos Onementioning

confidence: 99%

Assessing the mechanisms of multi-drug resistant non-typhoidal Salmonella (NTS) serovars isolated from layer chicken farms in Nigeria

Fagbamila,

Ramon,

Lettini

et al. 2023

PLoS ONE

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Background In Nigeria, there have been reports of widespread multiple antimicrobial resistance (AMR) amongst Salmonella isolated from poultry. To mitigate the impact of mortality associated with Salmonella on their farms, farmers resort to the use of antimicrobials without sound diagnostic advice. We conducted this study to describe the AMR patterns, mechanisms and genetic similarities within some Salmonella serovars isolated from different layer farms. Method We determine the AMR profiles of two hundred Salmonella isolates, selected based on frequency, serovar, and geographical and sample type distribution. We also assessed the mechanisms of multi-drug resistance for specific genetic determinants by using PCR protocols and gene sequence analysis. Pulsed-field gel electrophoresis (PFGE) was conducted on seven selected serovars to determine their genetic relatedness. Results Of 200 isolates, 97 (48.5%) revealed various AMR profiles, with the multiple antibiotic resistance (MAR) index ranging from 0.07–0.5. Resistance to ciprofloxacin was common in all the multi-drug resistant isolates, while all the isolates were susceptible to cefotaxime, ceftazidime, and meropenem. Genotypic characterization showed the presence of resistance genes as well as mutations in the nucleotide genes with subsequent amino acid substitutions. Fifteen isolates (43%) of S. Kentucky were indistinguishable, but were isolated from four different states in Nigeria (Ogun, n = 9; Kaduna, n = 6; Plateau, n = 3, and: Bauchi, n = 2). PFGE revealed 40 pulsotype patterns (Kentucky, n = 12; Larochelle, n = 9; Virchow, n = 5; Saintpaul, n = 4; Poona, n = 3; Isangi, n = 2, and; Nigeria, n = 2). Conclusion This study recorded strictly related but diversely distributed Salmonella serovars with high AMR rates in poultry. We recommend strict regulation on antimicrobial use and regular monitoring of AMR trends among bacteria isolated from animals and humans to inform public policy.

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Section: Plos Onementioning

confidence: 99%

Assessing the mechanisms of multi-drug resistant non-typhoidal Salmonella (NTS) serovars isolated from layer chicken farms in Nigeria

Fagbamila,

Ramon,

Lettini

et al. 2023

PLoS ONE

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“…Similar serovars have been reported in other studies around the world in farm animals causing diarrhea. [27][28][29] Although the three main serovars found in this study are uncommonly related to nontyphoidal salmonellosis, epidemiological outbreaks have been detected in Mexico and the rest of the world. [30][31][32] Salmonella isolates were classified into 18 STs according to the MLST.…”

Section: Discussionmentioning

confidence: 95%

Genomic perspective of Salmonella enterica isolated from farm animals in Sinaloa, Mexico

Campo,

Aguirre-Sanchez,

Irvin

et al. 2024

IJMR

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Farm animals play a crucial role as a primary source of sustenance for human consumption. However continues to be one of the major food-borne pathogens from a public health standpoint. Its persistent global concern surrounding stems from its capability to induce foodborne illnesses. Unraveling the genetic characteristics of this pathogen stands as a pivotal step, shedding light on the intricate biology of and aiming to mitigate its prevalence. Within this context, our study aims to delve into the genomic traits and population structure of Mexican isolates derived from farm animals. We performed next-generation sequencing across 72 genomes. Genomic data was analyzed to determine virulence and antibiotic resistance markers. In addition, a phylogenetic tree and a spanning tree was constructed. The study revealed a diversity of 18 serovars linked to a singular ST, with prominent serovars being Oranienburg, Give, and Saintpaul. Across all isolates, an extensive array of virulence-related genes was identified. Interestingly, 95% of the isolates displayed exclusive resistance to aminoglycosides, while the remaining exhibited multidrug resistance to tetracycline and chloramphenicol. Notably, a substantial prevalence of prophages in the genomes was observed, accounting for 94% and totaling 183 sequences. The serovar Give stood out with the highest number of sequences, featuring Vibrio X29 and Escher RCS47 as the most prevalent phages. This comprehensive analysis provides valuable insights into the intricate world of , paving the way for enhanced understanding and targeted interventions.

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“…Salmonella, a Gram-negative, rodshaped bacterium found within the Enterobacteriaceae family, encompasses two species: Salmonella enterica and Salmonella bongori. This diverse group includes over 2600 S. enterica serovars, many of which have the potential to cause diseases in both humans and animals (Zahra et al 2023) while certain Salmonella variants like Salmonella gallinarum (SG) and Salmonella pullorum (SP) lack flagella and motility, most Salmonella strains exhibit motility through peritrichous flagella. The presence of SG and SP in poultry is associated with clinical illness and substantial economic impacts on poultry farming, particularly in less developed nations (Syed Abu Thahir et al 2023).…”

Section: Role Of Salmonella In Amr Spreadmentioning

confidence: 99%

Role of Escherichia coli, Staphylococcus, Salmonella and Brucella Species in Spread of Antimicrobial Resistance Across Species

2023

IJAB

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Antimicrobial Resistance (AMR) has emerged as a critical global concern in the 21st century, presenting a "Quiet Pandemic" with escalating infection occurrences and a dearth of novel antimicrobial drugs. This paper explores the causes, prevalence, and regional implications of AMR, focusing on the One Health Approach initiated by international organizations like OIE and FAO. In Pakistan, a national action plan has been implemented to address AMR. The causes of AMR include the unnecessary use and misuse of antimicrobials, inappropriate prescribing patterns, and the lack of new novel antibiotics. The global prevalence of AMR is particularly high in sub-Saharan Africa and low-to middle-income countries, with specific concerns about colistin resistance mediated by MCR-1 in China. Insufficient public understanding of antimicrobials is also identified as a significant factor contributing to AMR. A comparative study between the UK and India highlights variations in public awareness, potentially impacting the incidence of infectious diseases. Vigilant monitoring of AMR-related infections and mortality rates is crucial, with projections indicating a potential rise in global mortality by 2050. The roles of key bacteria, including Escherichia coli, Staphylococcus aureus, Salmonella, and Brucella, in the spread of AMR are discussed. E. coli, for example, harbors resistance genes from both human and animal sources, posing a threat to both populations. Similarly, the emergence of methicillin-resistant Staphylococcus aureus (MRSA) complicates treatment, while Salmonella contributes to global foodborne illnesses.

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Distribution and Prevalence of Antimicrobial Resistance of NTS Salmonella Isolated from Farm Animals and Animal Food Products in Africa

Cited by 3 publications

References 41 publications

Assessing the mechanisms of multi-drug resistant non-typhoidal Salmonella (NTS) serovars isolated from layer chicken farms in Nigeria

Assessing the mechanisms of multi-drug resistant non-typhoidal Salmonella (NTS) serovars isolated from layer chicken farms in Nigeria

Genomic perspective of Salmonella enterica isolated from farm animals in Sinaloa, Mexico

Role of Escherichia coli, Staphylococcus, Salmonella and Brucella Species in Spread of Antimicrobial Resistance Across Species

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