Distribution and Migration of Human Placental Mesenchymal Stromal Cells in the Brain of Healthy Rats after Stereotaxic or Intra-Arterial Transplantation

Sukhinich, K. K.; Namestnikova, Daria; Gubskii, I L; Габашвили, А. Н.; Melnikov, Pavel; Vitushev, E; Vishnevskii, D A; Revkova, V. A.; Соловьева, А. А.; Voitkovskaya, К.; Вахрушев, И. В.; Burunova, V. V.; Бердалин, А. Б.; Александрова, М. А.; Чехонин, В. П.; Губский, Л.В.; Yarygin, K N

doi:10.1007/s10517-020-04750-8

Cited by 10 publications

(8 citation statements)

References 29 publications

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“…Therefore, the use of a permeabilizing agent could be essential to allow the passage of MSCs into the brain. On the other hand, selective delivery of cells might help MSCs reach the damaged areas [51,53]. As occurred with IV injection, some pathological entities can modify the biodistribution of MSCs after IA injection.…”

Section: Distribution Of Mscs After Intraarterial Injection In Animal Modelsmentioning

confidence: 99%

Biodistribution of Mesenchymal Stromal Cells after Administration in Animal Models and Humans: A Systematic Review

Sánchez‐Díaz

Quiñones-Vico

Torre

et al. 2021

JCM

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Mesenchymal Stromal Cells (MSCs) are of great interest in cellular therapy. Different routes of administration of MSCs have been described both in pre-clinical and clinical reports. Knowledge about the fate of the administered cells is critical for developing MSC-based therapies. The aim of this review is to describe how MSCs are distributed after injection, using different administration routes in animal models and humans. A literature search was performed in order to consider how MSCs distribute after intravenous, intraarterial, intramuscular, intraarticular and intralesional injection into both animal models and humans. Studies addressing the biodistribution of MSCs in “in vivo” animal models and humans were included. After the search, 109 articles were included in the review. Intravenous administration of MSCs is widely used; it leads to an initial accumulation of cells in the lungs with later redistribution to the liver, spleen and kidneys. Intraarterial infusion bypasses the lungs, so MSCs distribute widely throughout the rest of the body. Intramuscular, intraarticular and intradermal administration lack systemic biodistribution. Injection into various specific organs is also described. Biodistribution of MSCs in animal models and humans appears to be similar and depends on the route of administration. More studies with standardized protocols of MSC administration could be useful in order to make results homogeneous and more comparable.

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Section: Distribution Of Mscs After Intraarterial Injection In Animal Modelsmentioning

confidence: 99%

Biodistribution of Mesenchymal Stromal Cells after Administration in Animal Models and Humans: A Systematic Review

Sánchez‐Díaz

Quiñones-Vico

Torre

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…However, in transplantation to the corpus callosum, MSCs were observed to migrate along white matter tracts around cerebral blood vessels. [ 202 ]…”

Section: Methods Of Transplantation Used In the Treatment Of Cns Damamentioning

confidence: 99%

“…[ 210,216 ] MSCs intraarterially delivered to a healthy brain have been present in the motor and sensory cortex, hippocampus, striatum, thalamus, and hypothalamus. [ 202 ] In most studies, the cells are observed inside brain blood vessels or close to at least three days after transplantation. [ 202,217 ] The time from brain damage to transplantation is important for the degree of CNS colonization by intraarterially delivered cells.…”

Section: Methods Of Transplantation Used In the Treatment Of Cns Damamentioning

confidence: 99%

“…[ 202 ] In most studies, the cells are observed inside brain blood vessels or close to at least three days after transplantation. [ 202,217 ] The time from brain damage to transplantation is important for the degree of CNS colonization by intraarterially delivered cells. The best results are achieved when the cells are transplanted within 48–72 h after injury.…”

Section: Methods Of Transplantation Used In the Treatment Of Cns Damamentioning

confidence: 99%

“…In current literature, we found an increasing number of papers that showed that the perivascular space of blood vessels could be the destination site for transplanted MSCs within the damaged CNS area. [ 202,203,217 ] Information can also be found about incorporating intravascularly administered MSCs into the vascular wall, probably through their integration into the endothelial cell layer. [ 220,250,258,266 ] According to the literature, the time needed for MSCs to migrate through endothelial cells is reported as 120 minutes (min), 240 min, 24 h, or 72 h. [ 217,240,250,258,259,267 ] One of the possible causes inducing the migration of cells from the lumen of the blood vessel to perivascular space may be developing hypoxia result in the death of a large proportion of cells due to low oxygen levels in clogged microvessels.…”

Section: Methods Of Transplantation Used In the Treatment Of Cns Damamentioning

confidence: 99%

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Mesenchymal Stem Cells for Neurological Disorders

et al. 2021

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Neurological disorders are becoming a growing burden as society ages, and there is a compelling need to address this spiraling problem. Stem cell‐based regenerative medicine is becoming an increasingly attractive approach to designing therapies for such disorders. The unique characteristics of mesenchymal stem cells (MSCs) make them among the most sought after cell sources. Researchers have extensively studied the modulatory properties of MSCs and their engineering, labeling, and delivery methods to the brain. The first part of this review provides an overview of studies on the application of MSCs to various neurological diseases, including stroke, traumatic brain injury, spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, Parkinson's disease, and other less frequently studied clinical entities. In the second part, stem cell delivery to the brain is focused. This fundamental but still understudied problem needs to be overcome to apply stem cells to brain diseases successfully. Here the value of cell engineering is also emphasized to facilitate MSC diapedesis, migration, and homing to brain areas affected by the disease to implement precision medicine paradigms into stem cell‐based therapies.

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MRI-Based and Histologically Verified 3D Modeling of Spatial Distribution of Intra-Arterially Transplanted Cells in Rat Brain

et al. 2021

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Distribution and Migration of Human Placental Mesenchymal Stromal Cells in the Brain of Healthy Rats after Stereotaxic or Intra-Arterial Transplantation

Cited by 10 publications

References 29 publications

Biodistribution of Mesenchymal Stromal Cells after Administration in Animal Models and Humans: A Systematic Review

Biodistribution of Mesenchymal Stromal Cells after Administration in Animal Models and Humans: A Systematic Review

Mesenchymal Stem Cells for Neurological Disorders

MRI-Based and Histologically Verified 3D Modeling of Spatial Distribution of Intra-Arterially Transplanted Cells in Rat Brain

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