Distribution and interactions of priority heavy metals with some antioxidant micronutrients in inhabitants of a lead-zinc mining community of ebonyi state, Nigeria

Abstract

Background: Human exposure to xenobiotics, especially priority heavy metals (lead, cadmium, arsenic, mercury and chromium), is unavoidable because of their involvement in industrial applications, accumulation in the environment over time and non-biodegradability. Unfortunately, they induce unprecedented biochemical and pathological changes on those exposed to them, causing oxidative damages and organ toxicities. Aim: This study investigated the frequencies of priority heavy metals and their impact on some micronutrient elements (copper, iron, zinc) in the blood of inhabitants of a lead-zinc mining community in southeastern Nigeria.

Investigation of the protective effect of chitosan against arsenic-induced nephrotoxicity and oxidative damage in rat kidney tissue

“…Determination of serum electrolyte levels is important in assessing the tubular integrity of the nephron (Bagga et al 2005) . It has been reported that mineral levels are affected due to nephrotoxicity caused by some heavy metals (Tilako et al 2020). It was reported that sodium arsenite administration in rats caused significant increases in serum K + (Ewere et al 2019, Sharma et al 2022, and Cland Na + (Ewere et al 2019) levels.…”

Dose-dependent interaction of two heavy metals with amiodarone toxicity in Saccharomyces cerevisiae

“…Human exposure occurs through consumption of contaminated food and water, inhalation of polluted air, smoking cigarettes (Domingo-Relloso et al, 2020), and definitely through occupation (Azeh Engwa et al, 2019). Heavy metal pollution in proximity to industries was reported to alter antioxidant activities and other biological functions of micronutrient in both occupationally exposed and environmentally exposed subjects (Bello et al, 2020).…”