2001
DOI: 10.1016/s0006-8993(01)02302-2
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Distribution and immunohistochemical characterization of torsinA immunoreactivity in rat brain

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Cited by 49 publications
(40 citation statements)
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“…It is intriguing to note, in the context of our observations, that the brains of patients with major depression exhibit a greater availability of DAT (Laasonen-Balk et al, 1999;Brunswick et al, 2003). Importantly, torsinA expression is not exclusive to DA neurons (Walker et al, 2001;Oberlin et al, 2004;Xiao et al, 2004). Therefore, the activity of torsins in modulating polytopic protein levels may have alternative consequences on different targets (i.e., transporters, channel proteins) within other neuronal subtypes.…”
Section: Consequences For Eotdmentioning
confidence: 77%
“…It is intriguing to note, in the context of our observations, that the brains of patients with major depression exhibit a greater availability of DAT (Laasonen-Balk et al, 1999;Brunswick et al, 2003). Importantly, torsinA expression is not exclusive to DA neurons (Walker et al, 2001;Oberlin et al, 2004;Xiao et al, 2004). Therefore, the activity of torsins in modulating polytopic protein levels may have alternative consequences on different targets (i.e., transporters, channel proteins) within other neuronal subtypes.…”
Section: Consequences For Eotdmentioning
confidence: 77%
“…In addition, recent evidence indicates that a significant pool of torsinA exhibits a topology in which the AAA ϩ domain faces the cytoplasm (20). In support of this topology, torsinA is found in the cytoplasm, neuronal processes, and synaptic terminals (2,3,15,(23)(24)(25)(26) and has been shown to bind cytosolic proteins snapin (27) and kinesin light chain 1 (20). TorsinA has been proposed to play a role in several cellular processes, including dopaminergic neurotransmission (28 -31), NE organization and dynamics (17,22,32), and protein trafficking (27,33).…”
mentioning
confidence: 89%
“…These findings suggest an imbalance in dopaminergic neurotransmission and lend credence to the idea of a functional disturbance in patients with DYT1 dystonia. Interestingly, in situ hybridization and immunocytochemical studies have revealed high-level torsinA protein expression within dopaminergic neurons of the substantia nigra pars compacta and cholinergic interneurons of the striatum Walker et al, 2001;Oberlin et al, 2004;Xiao et al, 2004;Vasudevan et al, 2006). Furthermore, torsinA has been shown to protect dopaminergic neurons from oxidative stress (Kuner et al, 2004;Cao et al, 2005).…”
Section: Introductionmentioning
confidence: 99%