The species Polygonum arenarium (fam. Polygonaceae) was registered in the vicinity of Prilep, during the field research that was conducted in the surroundings of this city. The first literature data on the presence of this species in the flora of the Republic of North Macedonia are given by Velenovsky (1922), in the surroundings of Prilep, but these data have not been confirmed yet. This species is considered to be an integral part of the Macedonian flora for decades, however, its later confirmation is due to its morphological similarity to the species Polygonum arenastrum. A brief description of the most important morphological features of the species and a description of the habitat where it was found are given.