Distribution and Functional Implication of Secretin in Multiple Brain Regions

Wang, Ruanna; Chow, Billy K. C.; Zhang, Li

doi:10.1007/s12031-018-1089-z

Cited by 10 publications

(6 citation statements)

References 81 publications

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“…Secretin can be regarded as another putative regulator of the reproductive axis, although limited information has been available about the exact role of secretin in the regulation of reproduction so far (Wang et al, 2018). In an early study, intracerebral (IC) injection of secretin into the preoptic region of rats resulted in 10-fold elevation of luteinizing hormone (LH) concentration in the plasma (Kimura et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

Secretin Regulates Excitatory GABAergic Neurotransmission to GnRH Neurons via Retrograde NO Signaling Pathway in Mice

Csillag

Vastagh

Liposits

et al. 2019

Front. Cell. Neurosci.

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In mammals, reproduction is regulated by a wide range of metabolic hormones that maintain the proper energy balance. In addition to regulating feeding and energy expenditure, these metabolic messengers also modulate the functional performance of the hypothalamic-pituitary-gonadal (HPG) axis. Secretin, a member of the secretin-glucagon-vasoactive intestinal peptide hormone family, has been shown to alter reproduction centrally, although the underlying mechanisms have not been explored yet. In order to elucidate its central action in the neuroendocrine regulation of reproduction, in vitro electrophysiological slice experiments were carried out on GnRH-GFP neurons in male mice. Bath application of secretin (100 nM) significantly increased the frequency of the spontaneous postsynaptic currents (sPSCs) to 118.0 ± 2.64% compared to the control, and that of the GABAergic miniature postsynaptic currents (mPSCs) to 147.6 ± 19.19%. Resting membrane potential became depolarized by 12.74 ± 4.539 mV after secretin treatment. Frequency of evoked action potentials (APs) also increased to 144.3 ± 10.8%. The secretin-triggered elevation of the frequency of mPSCs was prevented by using either a secretin receptor antagonist (3 μM) or intracellularly applied G-protein-coupled receptor blocker (GDP-β-S; 2 mM) supporting the involvement of secretin receptor in the process. Regarding the actions downstream to secretin receptor, intracellular blockade of protein kinase A (PKA) with KT-5720 (2 μM) or intracellular inhibition of the neuronal nitric oxide synthase (nNOS) by NPLA (1 μM) abolished the stimulatory effect of secretin on mPSCs. These data suggest that secretin acts on GnRH neurons via secretin receptors whose activation triggers the cAMP/PKA/nNOS signaling pathway resulting in nitric oxide release and in the presynaptic terminals this retrograde NO machinery regulates the GABAergic input to GnRH neurons.

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Section: Introductionmentioning

confidence: 99%

Secretin Regulates Excitatory GABAergic Neurotransmission to GnRH Neurons via Retrograde NO Signaling Pathway in Mice

Csillag

Vastagh

Liposits

et al. 2019

Front. Cell. Neurosci.

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“…Apart from androgen receptor gene expression, we also found an increase in expression of the secretin receptor in bold individuals. Secretin receptor expression is widespread in the brain and although central secretin signaling is primarily known for its role in regulating neurodevelopment and memory function via effects on synaptic plasticity, secretin has also been shown to regulate anxiety and associated behaviors (Nishijima et al, 2006; Wang et al, 2019), as well as activity of reproductive circuitry (Csillag et al, 2019). Secretin has been shown to regulate GABAergic transmission to gonadotropin-releasing hormone-producing cells (Csillag et al, 2019), as well as affecting the firing rate of over 50% of examined paraventricular hypothalamus neurons in rat in vivo studies (Chen et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Social boldness correlates with brain gene expression in male green anoles

Kabelik

Julien

Ramirez

et al. 2021

Preprint

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Within populations, some individuals tend to exhibit a bold or shy social behavior phenotype relative to the mean. The neural underpinnings of these differing phenotypes – also described as syndromes, personalities, and coping styles – is an area of ongoing investigation. Although a social decision-making network has been described across vertebrate taxa, most studies examining activity within this network do so in relation to exhibited differences in behavioral expression. Our study instead focuses on constitutive gene expression in bold and shy individuals by isolating baseline gene expression profiles that influence social boldness predisposition, rather than those reflecting the results of social interaction and behavioral execution. We performed this study on male green anole lizards (Anolis carolinensis), an established model organism for behavioral research, which provides a crucial comparison group to investigations of birds and mammals. After identifying subjects as bold or shy through repeated reproductive and agonistic behavior testing, we used RNA sequencing to compare gene expression profiles between these groups within various forebrain, midbrain, and hindbrain regions. The ventromedial hypothalamus had the largest group differences in gene expression, with bold males having increased expression of calcium channels and neuroendocrine receptor genes compared to shy males. Conversely, shy males express more integrin alpha-10 in the majority of examined regions. There were no significant group differences in physiology or hormone levels. Our results highlight the ventromedial hypothalamus as an important center of behavioral differences across individuals and provide novel candidates for investigation into the regulation of individual variation in social behavior phenotype.

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“…This also holds true for VIP and PACAP, which have high degree of sequence similarity with secretin (Jozwiak-Bebenista et al, 2015). The activation of cAMP-PKA pathway exerts pluripotent functions, among which the modulation of ion channels or neurotransmitters directly affects synaptic transmission (Wang et al, 2019). Alternatively, other downstream pathways such as cAMP-response element -binding protein (CREB) activation (Mak et al, 2019) can initiate the translation of synaptic proteins to modulate long-term plasticity and memory functions.…”

Section: Secretinmentioning

confidence: 97%

“…Secretin is one classical gut-peptide hormone to modulate pancreatic secretion as well as body energy homeostasis. Several lines of evidence from rodent and human studies show that secretin and its receptors are widely distributed in the brain areas from cerebral cortex, hippocampus, amygdala, hypothalamus to cerebellum (Yuan et al, 2011;Wang et al, 2019). The neurological functions of secretin are also being gradually explored by molecular, physiological and behavioral approaches (Zhang and Chow, 2014;Wang et al, 2019).…”

Section: Secretinmentioning

confidence: 99%