Distribution and fate of macrophagic ameboid cells in the rat brain.

Imamoto, Kikuko; Fujiwara, Ryota; Nagai, Toshisaburo; Maeda, Toshihiro

doi:10.1679/aohc.45.505

Cited by 29 publications

(15 citation statements)

References 13 publications

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“…In our previous report, we have also stressed that the ameboid cells appearing not only in the ventricular cavity but also in the brain parenchyma are derived from the circulating monocytes (IMAMOTO et al, 1982). MCKENNA and CHAIRETAKIS (1980) have noted the fact that both the supraependymal and subependymal macrophages react to stains for microglial cells, and thus have insisted that the supra-and subependymal cells are probably an identical cell type capable of exchanging locations.…”

Section: Resultsmentioning

confidence: 91%

“…In the previous report we investigated the distribution and fate of macrophagic ameboid cells following an intravenous injection of primuline in neonatal rats, and concluded that the primuline-labeled ameboid cells in the brain parenchyma were phagocytic cells derived from blood monocytes and destined to become microglia (IMAMOTO et al, 1982). In addition, we postulated that some of subependymal ameboid cells arose from the ventricular cavity, passing through the ependymal lining, on the basis of their morphological similarities to the primuline-labeled free cells in the ventricular cavity.…”

Section: Discussionmentioning

confidence: 99%

“…Thirty-two rats were injected with 12 tl of 10°o primuline either at birth or one day after birth in the same manner as in the previous study (IMAMOTO et al, 1982). The rest were non-injected controls.…”

Section: Methodsmentioning

confidence: 99%

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Macrophagic ameboid cells in the brain ventricles of the neonatal rat.

Imamoto

1984

Arch. Histol. Jap., Arch. Histol. Jpn

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Section: Resultsmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Macrophagic ameboid cells in the brain ventricles of the neonatal rat.

Imamoto

1984

Arch. Histol. Jap., Arch. Histol. Jpn

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“…In a subsequent study, Valentino and Jones [1981] showed that these labelled cells were in fact neural macro phages. A recent investigation by Leong et al [1983] confirmed this and designated the labelled cells as amoeboid microglia, a transitory population of macro phages normally residing in the developing brain [Ling and Tan, 1974;Ferrer and Sarmiento, 1980;Imamoto et al, 1982], In their study of postnatal rats, Leong et al [1983] applied HRP directly on or in the exposed spinal cord at the cervical or lumbosacral enlargement and found the amoeboid microglial cells in the corpus callosum as well as cavum septum pellucidi labelled with the enzyme. Recently, Innocenti et al [1983a, b] also found HRP-labelled macrophages similar to amoeboid microglia in the white matter of the developing visual cortex in kittens after direct injections of HRP-bound wheat germ agglutinin in the visual areas.…”

Section: Ivy and Killackeymentioning

confidence: 95%

Labelling of Amoeboid Microglial Cells in Rats of Various Ages following an Intravenous Injection of Horseradish Peroxidase

Kaur¹,

Ling²,

Wong³

1986

Cells Tissues Organs

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The macrophagic amoeboid microglial cells in the corpus callosum of postnatal rats were labelled following an intravenous injection of horseradish peroxidase (HRP). The earliest time when these cells were labelled was 3 h after the injection of HRP in postnatal (1–10 days) rats. Similar cells around the mesencephalic aqueduct and the fourth ventricle were also labelled. These cells, however, were weakly labelled in developing (11–20 days) and unlabelled in weaning (21–30 days) rats. The results suggest that in the postnatal rats, the HRP passed through the endothehal lining of the blood vessels and was then ingested by the amoeboid microglial cells. In the developing and older rats, the wall of blood vessels had developed fully thereby preventing the free passage of HRP into the brain tissues.

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“…Macrophages are considered to originate from monocytes in the blood (Imamoto et al, 1982). Experimental manipulations have been found to increase the number of macrophages within the ventricles.…”

Section: Macrophagesmentioning

confidence: 99%

A scanning and transmission electron microscopic analysis of the cerebral aqueduct in the rabbit

Meller

Dennis

1993

Anat. Rec.

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An examination of the surface of the cerebral aqueduct with the scanning electron microscope revealed that the walls of the cerebral aqueduct were so heavily ciliated that most of the ependymal surface was obscured, yet certain specialized supraependymal structures could be discerned lying on (or embedded within) this matt of cilia. These structures were determined by transmission electron microscopy and Golgi analysis to be either macrophages, supraependymal neurons, dendrites from medial periaqueductal gray neurons, or axons of unknown origin. Some axons, which were found to contain vesicles, appeared to make synaptic contacts with ependymal cells. Using the transmission electron microscope, the ependymal lining was found to consist of two different cell types: normal ependymal cells and tanycytes which have a long tapering basal process that was observed to contact blood vessels or, more rarely, seemed to terminate in relation to neuronal elements. While there have been previous reports on the structure of the third and lateral ventricles in other species, there are limited reports in the rabbit. The present report is not only the first description for the rabbit, but it is the first complete scanning and transmission electron microscopic analysis of the cerebral aqueduct in any species.

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Distribution and fate of macrophagic ameboid cells in the rat brain.

Cited by 29 publications

References 13 publications

Macrophagic ameboid cells in the brain ventricles of the neonatal rat.

Macrophagic ameboid cells in the brain ventricles of the neonatal rat.

Labelling of Amoeboid Microglial Cells in Rats of Various Ages following an Intravenous Injection of Horseradish Peroxidase

A scanning and transmission electron microscopic analysis of the cerebral aqueduct in the rabbit

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